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Items: 1 to 20 of 25


Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport.

Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF.

Shock. 2013 Feb;39(2):189-96. doi: 10.1097/SHK.0b013e31827e8ea3.


IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism.

Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF.

FASEB J. 2013 Mar;27(3):1095-106. doi: 10.1096/fj.12-219295. Epub 2012 Dec 6.


Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.

Lafargue M, Xu L, Carlès M, Serve E, Anjum N, Iles KE, Xiong X, Giffard R, Pittet JF.

FASEB J. 2012 Jul;26(7):2919-29. doi: 10.1096/fj.11-197384. Epub 2012 Apr 9.


PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice.

Goolaerts A, Lafargue M, Song Y, Miyazawa B, Arjomandi M, Carlès M, Roux J, Howard M, Parks DA, Iles KE, Pittet JF.

Thorax. 2011 Sep;66(9):788-96. doi: 10.1136/thx.2010.155788. Epub 2011 Jul 18.


Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice.

Bir N, Lafargue M, Howard M, Goolaerts A, Roux J, Carles M, Cohen MJ, Iles KE, Fernández JA, Griffin JH, Pittet JF.

Am J Respir Cell Mol Biol. 2011 Sep;45(3):632-41. doi: 10.1165/rcmb.2010-0397OC. Epub 2011 Jan 21.


Reactive species and pulmonary edema.

Iles KE, Song W, Miller DW, Dickinson DA, Matalon S.

Expert Rev Respir Med. 2009 Oct 1;3(5):487-496.


Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species.

Lazrak A, Iles KE, Liu G, Noah DL, Noah JW, Matalon S.

FASEB J. 2009 Nov;23(11):3829-42. doi: 10.1096/fj.09-135590. Epub 2009 Jul 13.


Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.

Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA.

Free Radic Biol Med. 2009 Apr 1;46(7):866-75. doi: 10.1016/j.freeradbiomed.2008.12.001. Epub 2008 Dec 14.


Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter.

Vayalil PK, Iles KE, Choi J, Yi AK, Postlethwait EM, Liu RM.

Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1281-92. Epub 2007 Sep 21.


The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages.

Liu H, Zhang H, Iles KE, Rinna A, Merrill G, Yodoi J, Torres M, Forman HJ.

Free Radic Res. 2006 Aug;40(8):865-74.


Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression.

Wright MM, Schopfer FJ, Baker PR, Vidyasagar V, Powell P, Chumley P, Iles KE, Freeman BA, Agarwal A.

Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4299-304. Epub 2006 Mar 6.


Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands.

Baker PR, Lin Y, Schopfer FJ, Woodcock SR, Groeger AL, Batthyany C, Sweeney S, Long MH, Iles KE, Baker LM, Branchaud BP, Chen YE, Freeman BA.

J Biol Chem. 2005 Dec 23;280(51):42464-75. Epub 2005 Oct 14.


4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.

Zhang H, Liu H, Iles KE, Liu RM, Postlethwait EM, Laperche Y, Forman HJ.

Am J Respir Cell Mol Biol. 2006 Feb;34(2):174-81. Epub 2005 Sep 29.


HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells.

Iles KE, Dickinson DA, Wigley AF, Welty NE, Blank V, Forman HJ.

Free Radic Biol Med. 2005 Aug 1;39(3):355-64. Epub 2005 Apr 9.


Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal.

Iles KE, Liu RM.

Free Radic Biol Med. 2005 Mar 1;38(5):547-56. Review.


Analysis of transcription factor remodeling in phase II gene expression with curcumin.

Dickinson DA, Iles KE, Wigley AF, Forman HJ.

Methods Enzymol. 2004;378:302-18. Review. No abstract available.


Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress.

Krzywanski DM, Dickinson DA, Iles KE, Wigley AF, Franklin CC, Liu RM, Kavanagh TJ, Forman HJ.

Arch Biochem Biophys. 2004 Mar 1;423(1):116-25.


HNE--signaling pathways leading to its elimination.

Forman HJ, Dickinson DA, Iles KE.

Mol Aspects Med. 2003 Aug-Oct;24(4-5):189-94. Review.


Cytoprotection against oxidative stress and the regulation of glutathione synthesis.

Dickinson DA, Moellering DR, Iles KE, Patel RP, Levonen AL, Wigley A, Darley-Usmar VM, Forman HJ.

Biol Chem. 2003 Apr;384(4):527-37. Review.


Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression.

Dickinson DA, Iles KE, Zhang H, Blank V, Forman HJ.

FASEB J. 2003 Mar;17(3):473-5. Epub 2003 Jan 2.

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