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Results: 9

1.

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators.

Bemis JE, Vu CB, Xie R, Nunes JJ, Ng PY, Disch JS, Milne JC, Carney DP, Lynch AV, Jin L, Smith JJ, Lavu S, Iffland A, Jirousek MR, Perni RB.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2350-3. doi: 10.1016/j.bmcl.2008.11.106. Epub 2008 Dec 6.

PMID:
19303289
2.

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O.

BMC Syst Biol. 2009 Mar 10;3:31. doi: 10.1186/1752-0509-3-31.

3.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.

Nature. 2007 Nov 29;450(7170):712-6.

4.

Fluorescent cardiac imaging: a novel intraoperative method for quantitative assessment of myocardial perfusion during graded coronary artery stenosis.

Detter C, Wipper S, Russ D, Iffland A, Burdorf L, Thein E, Wegscheider K, Reichenspurner H, Reichart B.

Circulation. 2007 Aug 28;116(9):1007-14. Epub 2007 Aug 7.

5.

Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.

Iffland A, Kohls D, Low S, Luan J, Zhang Y, Kothe M, Cao Q, Kamath AV, Ding YH, Ellenberger T.

Biochemistry. 2005 Jun 14;44(23):8312-25.

PMID:
15938621
6.

Near-infrared fluorescence coronary angiography: a new noninvasive technology for intraoperative graft patency control.

Detter C, Russ D, Iffland A, Wipper S, Schurr MO, Reichenspurner H, Buess G, Reichart B.

Heart Surg Forum. 2002;5(4):364-9.

PMID:
12538119
7.

Examining reactivity and specificity of cytochrome c peroxidase by using combinatorial mutagenesis.

Wilming M, Iffland A, Tafelmeyer P, Arrivoli C, Saudan C, Johnsson K.

Chembiochem. 2002 Nov 4;3(11):1097-104.

PMID:
12404635
8.

Changing the substrate specificity of cytochrome c peroxidase using directed evolution.

Iffland A, Gendreizig S, Tafelmeyer P, Johnsson K.

Biochem Biophys Res Commun. 2001 Aug 10;286(1):126-32.

PMID:
11485318
9.

Directed molecular evolution of cytochrome c peroxidase.

Iffland A, Tafelmeyer P, Saudan C, Johnsson K.

Biochemistry. 2000 Sep 5;39(35):10790-8.

PMID:
10978164
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