Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA.

Biochemistry. 2013 Jun 10. [Epub ahead of print]

PMID:: 23713684; [PubMed - as supplied by publisher]

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Effect of growth hormone, hyperbaric oxygen and combined therapy on the gastric serosa.

Adas G, Adas M, Arikan S, Sarvan AK, Toklu AS, Mert S, Barut G, Kamali S, Koc B, Tutal F.

World J Gastroenterol. 2013 May 21;19(19):2904-12. doi: 10.3748/wjg.v19.i19.2904.

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Inflammation marker, damage marker and anabolic hormone responses to resistance training with vascular restriction in older males.

Karabulut M, Sherk VD, Bemben DA, Bemben MG.

Clin Physiol Funct Imaging. 2013 Apr 23. doi: 10.1111/cpf.12044. [Epub ahead of print]

PMID:: 23701309; [PubMed - as supplied by publisher]

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Animal Protein Intakes during Early Life and Adolescence Differ in Their Relation to the Growth Hormone-Insulin-Like-Growth-Factor Axis in Young Adulthood.

Joslowski G, Remer T, Assmann KE, Krupp D, Cheng G, Garnett SP, Kroke A, Wudy SA, Günther AL, Buyken AE.

J Nutr. 2013 May 22. [Epub ahead of print]

PMID:: 23700336; [PubMed - as supplied by publisher]

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Insulin-like growth factor binding protein-3 (IGFBP-3): Novel ligands mediate unexpected functions.

Baxter RC.

J Cell Commun Signal. 2013 May 23. [Epub ahead of print]

PMID:: 23700234; [PubMed - as supplied by publisher]

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Role of insulin-like growth factor binding protein-3 in 1, 25-dihydroxyvitamin-d 3 -induced breast cancer cell apoptosis.

Brosseau C, Pirianov G, Colston KW.

Int J Cell Biol. 2013;2013:960378. doi: 10.1155/2013/960378. Epub 2013 Apr 18.

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Significant increase of IGF-I concentration and of IGF-I/IGFBP-3 molar ratio in generation test predicts the good response to growth hormone (GH) therapy in children with short stature and normal results of GH stimulating tests.

Smyczynska J, Hilczer M, Stawerska R, Lewinski A.

Neuro Endocrinol Lett. 2013 May 22;34(3):222-228. [Epub ahead of print]

PMID:: 23685421; [PubMed - as supplied by publisher]

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IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): multiple PAPP-A-IGFBP interaction sites.

Gaidamauskas E, Gyrup C, Boldt HB, Schack VR, Overgaard MT, Laursen LS, Oxvig C.

Biochim Biophys Acta. 2013 Mar;1830(3):2701-9.

PMID:: 23671931; [PubMed - in process]

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Figure 2

Kaplan Meier survival estimate of progression-free survival (PFS) and overall survival (OS) for OEC patients classified by (a) IGFBP-3 expression, (b) IGFBP-3 promoter methylation status and (c) p53 expression. (d) Survival estimate for patients with normal p53, classified according to IGFBP-3 expressions and IGFBP-3 promoter methylation status. --- indicates patients with high IGFBP-3 and IGFBP-3 promoter methylation ≤ 3%; --- indicates patients with unparallel IGFBP-3 and IGFBP-3 promoter methylation, i.e. either high IGFBP-3 and IGFBP-3 promoter methylation >; 3% or low IGFBP-3 and IGFBP-3 promoter methylation ≤ 3%; --·-indicates patients with low IGFBP-3 and IGFBP-3 promoter methylation > 3%. Logrank test was used to compare survival distributions.

Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma

Mol Cancer. 2009;8:120-120.
Figure 5IGFBP-3 activates the SR-Bl receptor leading to NO generation in endothelial cells

Determination of NO release in response to IGFBP-3 and HDL by DAF-FM fluorescence imaging. NO release in response to IGFBP-3 and/or HDL in HUVEC, HMEC and RGC-5 cells. Treatment with SRB1-Ab significantly decreased NO release by either IGFBP-3 or HDL or the combination of IGFBP-3 and HDL. (A-C) shown in the right were respective scales for fluorescence in three different cell types. Images obtained were cells that were either not treated (control) or treated as labeled. (D) Changes in fluorescence with different treatments were expressed as percent increase over the control.*P<0.05 and **P<0.02 compared with IGFBP-3; ***P<0.01 compared with HDL+IGFBP-3; ****P<0.0001 compared with HDL. #P<0.05 compared with IGFBP-3 or HDL alone; ##P<0.01 compared with HDL+IGFBP-3; ###P<0.001 compared with HDL or IGFBP-3. Representative results from three independent experiments are shown.

Insulin-like growth factor binding protein-3 (IGFBP-3) mediates vascular repair by enhancing nitric oxide generation

Circ Res. 2009 October 23;105(9):897-905.
Figure 4Insulin-like growth factors promote and TNFα inhibits IGFBP-3 production and secretion

Differentiation was manipulated with a single dose of 50 ng ml⁻¹ IGF-I, 50 ng ml⁻¹ LR3 IGF-I and 150 ng ml⁻¹ IGFBP-3, or with and without 20 ng ml⁻¹ TNFα. IGFBP-3 levels were determined at day 7 of differentiation. A, representative Western immunoblot of endogenous IGFBP-3 production from 50 μg of whole cell lysates (upper panel) with NHS control and IGFBP-3 spike representing the addition of nonglycosylated protein. The percentage change in IGFBP-3 production versus day 7 controls was calculated by densitometry from 5 individuals (lower panel). B, representative Western immunoblot of day 7 conditioned media, demonstrating IGFBP-3 secretion. C, the secretion of IGFBP-3 was confirmed by RIA. The data represent the mean IGFBP-3 levels ± s.e.m. from 5 individuals. Statistical analysis was performed using Student's paired t test; *P < 0.05, **P < 0.01, ***P < 0.001. NHS, normal human serum.

Isolation and validation of human prepubertal skeletal muscle cells: maturation and metabolic effects of IGF-I, IGFBP-3 and TNF?

J Physiol. 2005 October 1;568(Pt 1):229-242.
Figure 10IGFBP-3 causes Akt phosphorylation at Ser473.

A. Representative western blot depicting the time-course of Akt phosphorylation at Ser⁴⁷³ residue by 100 ng/ml IGFBP-3 and the bar graph (B) showing the pAkt⁴⁷³/Akt following IGFBP-3 stimulation (*P<0.01, n = 3). C. Representative western blot depicting the time-course of Akt phosphorylation at Thr³⁰⁸ residue by 100 ng/ml IGFBP-3 and the bar graph (D) showing the pAkt³⁰⁸/Akt following IGFBP-3 stimulation (n = 3). E. Representative western blot depicting the Akt-Ser⁴⁷³ phosphorylation by wild type (WT) and IGF-1 non-binding mutant of IGFBP-3 and the effects of PI3K inhibitor LY294002 (30 µM). F. WT and mutant IGFBP-3 phosphorylated Akt-Ser⁴⁷³ to similar extents and the phosphorylation by IGFBP-3 was blocked by LY294002 (*P<0.001, n = 3).

Protection of Blood Retinal Barrier and Systemic Vasculature by Insulin-Like Growth Factor Binding Protein-3

PLoS One. 2012;7(7):e39398.

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Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. [Aging Cell. 2008]
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.
Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO. Aging Cell. 2008 Oct; 7(5):681-7.
Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites. [Cancer Causes Control. 2012]
Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.
Keku TO, Vidal A, Oliver S, Hoyo C, Hall IJ, Omofoye O, McDoom M, Worley K, Galanko J, Sandler RS, et al. Cancer Causes Control. 2012 Jul; 23(7):1127-38. Epub 2012 May 8.
Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys. [Eur J Clin Nutr. 2009]
Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys.
Hoppe C, Mølgaard C, Dalum C, Vaag A, Michaelsen KF. Eur J Clin Nutr. 2009 Sep; 63(9):1076-83. Epub 2009 May 27.

513 free full-text articles in PubMed Central

Effect of growth hormone, hyperbaric oxygen and combined therapy on the gastric serosa. [World J Gastroenterol. 2013]
Effect of growth hormone, hyperbaric oxygen and combined therapy on the gastric serosa.
Adas G, Adas M, Arikan S, Sarvan AK, Toklu AS, Mert S, Barut G, Kamali S, Koc B, Tutal F. World J Gastroenterol. 2013 May 21; 19(19):2904-12.
Role of insulin-like growth factor binding protein-3 in 1, 25-dihydroxyvitamin-d 3 -induced breast cancer cell apoptosis. [Int J Cell Biol. 2013]
Role of insulin-like growth factor binding protein-3 in 1, 25-dihydroxyvitamin-d 3 -induced breast cancer cell apoptosis.
Brosseau C, Pirianov G, Colston KW. Int J Cell Biol. 2013; 2013:960378. Epub 2013 Apr 18.
Correlation of angiogenic biomarker signatures with clinical outcomes in metastatic colorectal cancer patients receiving capecitabine, oxaliplatin, and bevacizumab. [Cancer Med. 2013]
Correlation of angiogenic biomarker signatures with clinical outcomes in metastatic colorectal cancer patients receiving capecitabine, oxaliplatin, and bevacizumab.
Liu Y, Starr MD, Bulusu A, Pang H, Wong NS, Honeycutt W, Amara A, Hurwitz HI, Nixon AB. Cancer Med. 2013 Apr; 2(2):234-42. Epub 2013 Mar 6.

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