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Results: 1 to 20 of 186

1.

Memo is a copper-dependent redox protein with an essential role in migration and metastasis.

MacDonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Dolemeyer A, Frei A, Lienhard S, Wyckoff J, Hess D, Seebacher J, Keusch JJ, Gut H, Salaun D, Mazzarol G, Disalvatore D, Bentires-Alj M, Di Fiore PP, Badache A, Hynes NE.

Sci Signal. 2014 Jun 10;7(329):ra56. doi: 10.1126/scisignal.2004870.

PMID:
24917593
[PubMed - in process]
2.

Memo has a novel role in S1P signaling and crucial for vascular development.

Kondo S, Bottos A, Allegood JC, Masson R, Maurer FG, Genoud C, Kaeser P, Huwiler A, Murakami M, Spiegel S, Hynes NE.

PLoS One. 2014 Apr 8;9(4):e94114. doi: 10.1371/journal.pone.0094114. eCollection 2014.

PMID:
24714781
[PubMed - in process]
Free PMC Article
3.

EGF receptor family: twisting targets for improved cancer therapies.

Burgess AW, Henis YI, Hynes NE, Jovin T, Levitzki A, Pinkas-Kramarski R, Yarden Y.

Growth Factors. 2014 Apr;32(2):74-81. doi: 10.3109/08977194.2014.896355. Epub 2014 Mar 18.

PMID:
24641597
[PubMed - in process]
4.
5.

Loss of Memo, a novel FGFR regulator, results in reduced lifespan.

Haenzi B, Bonny O, Masson R, Lienhard S, Dey JH, Kuro-o M, Hynes NE.

FASEB J. 2014 Jan;28(1):327-36. doi: 10.1096/fj.13-228320. Epub 2013 Sep 20.

PMID:
24056085
[PubMed - indexed for MEDLINE]
6.

Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells.

Gattelli A, Nalvarte I, Boulay A, Roloff TC, Schreiber M, Carragher N, Macleod KK, Schlederer M, Lienhard S, Kenner L, Torres-Arzayus MI, Hynes NE.

EMBO Mol Med. 2013 Sep;5(9):1335-50. doi: 10.1002/emmm.201302625. Epub 2013 Jul 19.

PMID:
23868506
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Signalling change: signal transduction through the decades.

Hynes NE, Ingham PW, Lim WA, Marshall CJ, Massagué J, Pawson T.

Nat Rev Mol Cell Biol. 2013 Jun;14(6):393-8. doi: 10.1038/nrm3581. Epub 2013 May 2. Review.

PMID:
23636498
[PubMed - indexed for MEDLINE]
8.

Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models.

Issa A, Gill JW, Heideman MR, Sahin O, Wiemann S, Dey JH, Hynes NE.

Breast Cancer Res. 2013 Jan 23;15(1):R8. doi: 10.1186/bcr3379.

PMID:
23343422
[PubMed - in process]
Free PMC Article
9.

Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth.

Tarkkonen KM, Nilsson EM, Kähkönen TE, Dey JH, Heikkilä JE, Tuomela JM, Liu Q, Hynes NE, Härkönen PL.

PLoS One. 2012;7(11):e49970. doi: 10.1371/journal.pone.0049970. Epub 2012 Nov 21.

PMID:
23185502
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets.

Wöhrle S, Henninger C, Bonny O, Thuery A, Beluch N, Hynes NE, Guagnano V, Sellers WR, Hofmann F, Kneissel M, Graus Porta D.

J Bone Miner Res. 2013 Apr;28(4):899-911. doi: 10.1002/jbmr.1810.

PMID:
23129509
[PubMed - in process]
11.

Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion.

Aceto N, Duss S, MacDonald G, Meyer DS, Roloff TC, Hynes NE, Bentires-Alj M.

Breast Cancer Res. 2012 Oct 12;14(5):R131. doi: 10.1186/bcr3329.

PMID:
23062209
[PubMed - in process]
Free PMC Article
12.

The 14-3-3σ tumor suppressor has multiple functions in ErbB2-induced breast cancer.

Hynes NE, Smirnova T.

Cancer Discov. 2012 Jan;2(1):19-22. doi: 10.1158/2159-8290.CD-11-0317.

PMID:
22585164
[PubMed - indexed for MEDLINE]
13.

MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth.

Schlatter ID, Meira M, Ueberschlag V, Hoepfner D, Movva R, Hynes NE.

PLoS One. 2012;7(3):e32501. doi: 10.1371/journal.pone.0032501. Epub 2012 Mar 7.

PMID:
22412880
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone.

Wöhrle S, Bonny O, Beluch N, Gaulis S, Stamm C, Scheibler M, Müller M, Kinzel B, Thuery A, Brueggen J, Hynes NE, Sellers WR, Hofmann F, Graus-Porta D.

J Bone Miner Res. 2011 Oct;26(10):2486-97. doi: 10.1002/jbmr.478.

PMID:
21812026
[PubMed - indexed for MEDLINE]
15.

Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis.

Smirnova T, Zhou ZN, Flinn RJ, Wyckoff J, Boimel PJ, Pozzuto M, Coniglio SJ, Backer JM, Bresnick AR, Condeelis JS, Hynes NE, Segall JE.

Oncogene. 2012 Feb 9;31(6):706-15. doi: 10.1038/onc.2011.275. Epub 2011 Jul 4.

PMID:
21725367
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

P-Rex1, a guanine exchange factor that is overexpressed in breast cancer, is a convergence node for ErbB and CXCR4 signaling.

Hynes NE, Gattelli A.

Mol Cell. 2011 Jan 7;41(1):5-7. doi: 10.1016/j.molcel.2010.12.024.

PMID:
21211718
[PubMed]
Free Article
17.

Unfavorable drug interactions in targeted breast cancer therapy.

Groner B, Hynes NE.

Cancer Cell. 2010 Nov 16;18(5):401-2. doi: 10.1016/j.ccr.2010.10.027. No abstract available.

PMID:
21075302
[PubMed]
Free Article
18.

Potential for targeting the fibroblast growth factor receptors in breast cancer.

Hynes NE, Dey JH.

Cancer Res. 2010 Jul 1;70(13):5199-202. doi: 10.1158/0008-5472.CAN-10-0918. Epub 2010 Jun 22. Review. Erratum in: Cancer Res. 2010 Oct 1;70(19):7734.

PMID:
20570901
[PubMed - indexed for MEDLINE]
Free Article
19.

Mammary gland growth factors: roles in normal development and in cancer.

Hynes NE, Watson CJ.

Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a003186. doi: 10.1101/cshperspect.a003186. Epub 2010 Jun 16. Review.

PMID:
20554705
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis.

Dey JH, Bianchi F, Voshol J, Bonenfant D, Oakeley EJ, Hynes NE.

Cancer Res. 2010 May 15;70(10):4151-62. doi: 10.1158/0008-5472.CAN-09-4479. Epub 2010 May 11.

PMID:
20460524
[PubMed - indexed for MEDLINE]
Free Article

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