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Results: 1 to 20 of 33

1.

Structural Basis of G Protein-coupled Receptor-Gi Protein Interaction: FORMATION OF THE CANNABINOID CB2 RECEPTOR-Gi PROTEIN COMPLEX.

Mnpotra JS, Qiao Z, Cai J, Lynch DL, Grossfield A, Leioatts N, Hurst DP, Pitman MC, Song ZH, Reggio PH.

J Biol Chem. 2014 Jul 18;289(29):20259-72. doi: 10.1074/jbc.M113.539916. Epub 2014 May 22.

PMID:
24855641
[PubMed - in process]
2.

Pregnenolone can protect the brain from cannabis intoxication.

Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV.

Science. 2014 Jan 3;343(6166):94-8. doi: 10.1126/science.1243985. Erratum in: Science. 2014 Feb 28;343(6174):969.

PMID:
24385629
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Crucial positively charged residues for ligand activation of the GPR35 receptor.

Zhao P, Lane TR, Gao HG, Hurst DP, Kotsikorou E, Le L, Brailoiu E, Reggio PH, Abood ME.

J Biol Chem. 2014 Feb 7;289(6):3625-38. doi: 10.1074/jbc.M113.508382. Epub 2013 Dec 17.

PMID:
24347166
[PubMed - indexed for MEDLINE]
4.

Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.

Kotsikorou E, Sharir H, Shore DM, Hurst DP, Lynch DL, Madrigal KE, Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak LS, Croatt MP, Abood ME, Reggio PH.

Biochemistry. 2013 Dec 31;52(52):9456-69. doi: 10.1021/bi4008885. Epub 2013 Dec 17.

PMID:
24274581
[PubMed - indexed for MEDLINE]
5.

Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations.

Kimura T, Vukoti K, Lynch DL, Hurst DP, Grossfield A, Pitman MC, Reggio PH, Yeliseev AA, Gawrisch K.

Proteins. 2014 Mar;82(3):452-65. doi: 10.1002/prot.24411. Epub 2013 Oct 17.

PMID:
23999926
[PubMed - in process]
6.

The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).

Kotsikorou E, Navas F 3rd, Roche MJ, Gilliam AF, Thomas BF, Seltzman HH, Kumar P, Song ZH, Hurst DP, Lynch DL, Reggio PH.

J Med Chem. 2013 Sep 12;56(17):6593-612. doi: 10.1021/jm400070u. Epub 2013 Aug 14.

PMID:
23855811
[PubMed - indexed for MEDLINE]
7.

Endogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and molecular dynamics simulations.

Hurst DP, Schmeisser M, Reggio PH.

Chem Phys Lipids. 2013 Apr;169:46-56. doi: 10.1016/j.chemphyslip.2013.01.009. Epub 2013 Feb 26. Review.

PMID:
23485612
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling.

Zheng H, Pearsall EA, Hurst DP, Zhang Y, Chu J, Zhou Y, Reggio PH, Loh HH, Law PY.

BMC Cell Biol. 2012 Mar 19;13:6. doi: 10.1186/1471-2121-13-6.

PMID:
22429589
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Chromenopyrazoles: non-psychoactive and selective CB₁ cannabinoid agonists with peripheral antinociceptive properties.

Cumella J, Hernández-Folgado L, Girón R, Sánchez E, Morales P, Hurst DP, Gómez-Cañas M, Gómez-Ruiz M, Pinto DC, Goya P, Reggio PH, Martin MI, Fernández-Ruiz J, Silva AM, Jagerovic N.

ChemMedChem. 2012 Mar 5;7(3):452-63. doi: 10.1002/cmdc.201100568. Epub 2012 Feb 2.

PMID:
22302767
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.

Kotsikorou E, Madrigal KE, Hurst DP, Sharir H, Lynch DL, Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak L, Abood ME, Reggio PH.

Biochemistry. 2011 Jun 28;50(25):5633-47. doi: 10.1021/bi200010k. Epub 2011 Jun 1.

PMID:
21534610
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.

Huffman JW, Hepburn SA, Reggio PH, Hurst DP, Wiley JL, Martin BR.

Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. doi: 10.1016/j.bmc.2010.06.054. Epub 2010 Jun 22.

PMID:
20621488
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor.

Hurst DP, Grossfield A, Lynch DL, Feller S, Romo TD, Gawrisch K, Pitman MC, Reggio PH.

J Biol Chem. 2010 Jun 4;285(23):17954-64. doi: 10.1074/jbc.M109.041590. Epub 2010 Mar 10.

PMID:
20220143
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Residues accessible in the binding-site crevice of transmembrane helix 6 of the CB2 cannabinoid receptor.

Nebane NM, Hurst DP, Carrasquer CA, Qiao Z, Reggio PH, Song ZH.

Biochemistry. 2008 Dec 30;47(52):13811-21. doi: 10.1021/bi8007802.

PMID:
19053233
[PubMed - indexed for MEDLINE]
14.

Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinity.

Fan H, Kotsikorou E, Hoffman AF, Ravert HT, Holt D, Hurst DP, Lupica CR, Reggio PH, Dannals RF, Horti AG.

Eur J Med Chem. 2009 Feb;44(2):593-608. doi: 10.1016/j.ejmech.2008.03.040. Epub 2008 Apr 18.

PMID:
18511157
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Conformational memories with variable bond angles.

Whitnell RM, Hurst DP, Reggio PH, Guarnieri F.

J Comput Chem. 2008 Apr 15;29(5):741-52.

PMID:
17876759
[PubMed - indexed for MEDLINE]
16.

Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.

Anavi-Goffer S, Fleischer D, Hurst DP, Lynch DL, Barnett-Norris J, Shi S, Lewis DL, Mukhopadhyay S, Howlett AC, Reggio PH, Abood ME.

J Biol Chem. 2007 Aug 24;282(34):25100-13. Epub 2007 Jun 26.

PMID:
17595161
[PubMed - indexed for MEDLINE]
Free Article
17.

Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.

Kapur A, Hurst DP, Fleischer D, Whitnell R, Thakur GA, Makriyannis A, Reggio PH, Abood ME.

Mol Pharmacol. 2007 Jun;71(6):1512-24. Epub 2007 Mar 23.

PMID:
17384224
[PubMed - indexed for MEDLINE]
Free Article
18.

(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.

Picone RP, Khanolkar AD, Xu W, Ayotte LA, Thakur GA, Hurst DP, Abood ME, Reggio PH, Fournier DJ, Makriyannis A.

Mol Pharmacol. 2005 Dec;68(6):1623-35. Epub 2005 Sep 12.

PMID:
16157695
[PubMed - indexed for MEDLINE]
Free Article
19.

Adamantyl cannabinoids: a novel class of cannabinergic ligands.

Lu D, Meng Z, Thakur GA, Fan P, Steed J, Tartal CL, Hurst DP, Reggio PH, Deschamps JR, Parrish DA, George C, Järbe TU, Lamb RJ, Makriyannis A.

J Med Chem. 2005 Jul 14;48(14):4576-85.

PMID:
15999995
[PubMed - indexed for MEDLINE]
20.

Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template.

Zhang R, Hurst DP, Barnett-Norris J, Reggio PH, Song ZH.

Mol Pharmacol. 2005 Jul;68(1):69-83. Epub 2005 Apr 19.

PMID:
15840841
[PubMed - indexed for MEDLINE]
Free Article

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