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Results: 1 to 20 of 50

1.

Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells.

Shah VO, Ferguson JE, Hunsaker LA, Deck LM, Vander Jagt DL.

Nat Prod Res. 2010 Jul;24(12):1177-88. doi: 10.1080/14786410903112680.

PMID:
20582811
[PubMed - indexed for MEDLINE]
2.

Inhibition of nuclear factor kappaB activation and cyclooxygenase-2 expression by aqueous extracts of Hispanic medicinal herbs.

Orlando RA, Gonzales AM, Hunsaker LA, Franco CR, Royer RE, Vander Jagt DL, Vander Jagt DJ.

J Med Food. 2010 Aug;13(4):888-95. doi: 10.1089/jmf.2009.1128.

PMID:
20482259
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1.

Deck LM, Hunsaker LA, Gonzales AM, Orlando RA, Vander Jagt DL.

BMC Pharmacol. 2008 Nov 10;8:19. doi: 10.1186/1471-2210-8-19.

PMID:
19000313
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Efficient calculation of molecular properties from simulation using kernel molecular dynamics.

Brown WM, Sasson A, Bellew DR, Hunsaker LA, Martin S, Leitao A, Deck LM, Vander Jagt DL, Oprea TI.

J Chem Inf Model. 2008 Aug;48(8):1626-37. doi: 10.1021/ci8001233. Epub 2008 Aug 2.

PMID:
18672870
[PubMed - indexed for MEDLINE]
5.

Isocoumarin-based inhibitors of pancreatic cholesterol esterase.

Heynekamp JJ, Hunsaker LA, Vander Jagt TA, Royer RE, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2008 May 1;16(9):5285-94. doi: 10.1016/j.bmc.2008.03.016. Epub 2008 Mar 6.

PMID:
18353652
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB.

Heynekamp JJ, Weber WM, Hunsaker LA, Gonzales AM, Orlando RA, Deck LM, Jagt DL.

J Med Chem. 2006 Nov 30;49(24):7182-9.

PMID:
17125270
[PubMed - indexed for MEDLINE]
7.

TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin.

Weber WM, Hunsaker LA, Gonzales AM, Heynekamp JJ, Orlando RA, Deck LM, Vander Jagt DL.

Biochem Pharmacol. 2006 Oct 16;72(8):928-40. Epub 2006 Aug 28.

PMID:
16934760
[PubMed - indexed for MEDLINE]
8.

Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator.

Heynekamp JJ, Hunsaker LA, Vander Jagt TA, Deck LM, Vander Jagt DL.

BMC Chem Biol. 2006 Feb 8;6:1.

PMID:
16466576
[PubMed]
Free PMC Article
9.

Activation of NFkappaB is inhibited by curcumin and related enones.

Weber WM, Hunsaker LA, Roybal CN, Bobrovnikova-Marjon EV, Abcouwer SF, Royer RE, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2006 Apr 1;14(7):2450-61. Epub 2005 Dec 7.

PMID:
16338138
[PubMed - indexed for MEDLINE]
10.

Anti-oxidant activities of curcumin and related enones.

Weber WM, Hunsaker LA, Abcouwer SF, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2005 Jun 1;13(11):3811-20.

PMID:
15863007
[PubMed - indexed for MEDLINE]
11.

The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism.

Roybal CN, Hunsaker LA, Barbash O, Vander Jagt DL, Abcouwer SF.

J Biol Chem. 2005 May 27;280(21):20331-9. Epub 2005 Mar 23.

PMID:
15788408
[PubMed - indexed for MEDLINE]
Free Article
12.

Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites.

Brown WM, Yowell CA, Hoard A, Vander Jagt TA, Hunsaker LA, Deck LM, Royer RE, Piper RC, Dame JB, Makler MT, Vander Jagt DL.

Biochemistry. 2004 May 25;43(20):6219-29.

PMID:
15147206
[PubMed - indexed for MEDLINE]
13.

Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster.

Heidrich JE, Contos LM, Hunsaker LA, Deck LM, Vander Jagt DL.

BMC Pharmacol. 2004 Apr 19;4:5.

PMID:
15096274
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

17-beta-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold.

Brown WM, Metzger LE, Barlow JP, Hunsaker LA, Deck LM, Royer RE, Vander Jagt DL.

Chem Biol Interact. 2003 Feb 1;143-144:481-91.

PMID:
12604234
[PubMed - indexed for MEDLINE]
15.

Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase.

Vander Jagt DL, Hunsaker LA.

Chem Biol Interact. 2003 Feb 1;143-144:341-51.

PMID:
12604221
[PubMed - indexed for MEDLINE]
16.

Inhibition of yeast lipase (CRL1) and cholesterol esterase (CRL3) by 6-chloro-2-pyrones: comparison with porcine cholesterol esterase.

Stoddard Hatch M, Brown WM, Deck JA, Hunsaker LA, Deck LM, Vander Jagt DL.

Biochim Biophys Acta. 2002 Apr 29;1596(2):381-91.

PMID:
12007617
[PubMed - indexed for MEDLINE]
Free Article
17.

The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum.

Dando C, Schroeder ER, Hunsaker LA, Deck LM, Royer RE, Zhou X, Parmley SF, Vander Jagt DL.

Mol Biochem Parasitol. 2001 Nov;118(1):23-32.

PMID:
11704270
[PubMed - indexed for MEDLINE]
18.

Oxidative stress indices in IDDM subjects with and without long-term diabetic complications.

VanderJagt DJ, Harrison JM, Ratliff DM, Hunsaker LA, Vander Jagt DL.

Clin Biochem. 2001 Jun;34(4):265-70.

PMID:
11440725
[PubMed - indexed for MEDLINE]
19.

Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4.

Yu Y, Deck JA, Hunsaker LA, Deck LM, Royer RE, Goldberg E, Vander Jagt DL.

Biochem Pharmacol. 2001 Jul 1;62(1):81-9.

PMID:
11377399
[PubMed - indexed for MEDLINE]
20.

Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications.

Vander Jagt DL, Hassebrook RK, Hunsaker LA, Brown WM, Royer RE.

Chem Biol Interact. 2001 Jan 30;130-132(1-3):549-62.

PMID:
11306074
[PubMed - indexed for MEDLINE]

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