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Results: 13

1.

The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii.

Howard JC, Hunn JP, Steinfeldt T.

Curr Opin Microbiol. 2011 Aug;14(4):414-21. doi: 10.1016/j.mib.2011.07.002. Epub 2011 Jul 23. Review.

PMID:
21783405
[PubMed - indexed for MEDLINE]
2.

Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.

Traver MK, Henry SC, Cantillana V, Oliver T, Hunn JP, Howard JC, Beer S, Pfeffer K, Coers J, Taylor GA.

J Biol Chem. 2011 Sep 2;286(35):30471-80. doi: 10.1074/jbc.M111.251967. Epub 2011 Jul 12. Erratum in: J Biol Chem. 2013 Apr 19;288(16):11504.

PMID:
21757726
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii.

Pawlowski N, Khaminets A, Hunn JP, Papic N, Schmidt A, Uthaiah RC, Lange R, Vopper G, Martens S, Wolf E, Howard JC.

BMC Biol. 2011 Jan 28;9:7. doi: 10.1186/1741-7007-9-7.

PMID:
21276251
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.

Steinfeldt T, Könen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC.

PLoS Biol. 2010 Dec 21;8(12):e1000576. doi: 10.1371/journal.pbio.1000576.

PMID:
21203588
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens.

Hunn JP, Feng CG, Sher A, Howard JC.

Mamm Genome. 2011 Feb;22(1-2):43-54. doi: 10.1007/s00335-010-9293-3. Epub 2010 Oct 30. Review.

PMID:
21052678
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?

Hunn JP, Howard JC.

PLoS Pathog. 2010 Jul 15;6(7):e1001008. doi: 10.1371/journal.ppat.1001008. No abstract available.

PMID:
20664789
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.

Khaminets A, Hunn JP, Könen-Waisman S, Zhao YO, Preukschat D, Coers J, Boyle JP, Ong YC, Boothroyd JC, Reichmann G, Howard JC.

Cell Microbiol. 2010 Jul;12(7):939-61. doi: 10.1111/j.1462-5822.2010.01443.x. Epub 2010 Jan 26.

PMID:
20109161
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Toxoplasma gondii and the Immunity-Related GTPase (IRG) resistance system in mice: a review.

Zhao YO, Rohde C, Lilue JT, Könen-Waisman S, Khaminets A, Hunn JP, Howard JC.

Mem Inst Oswaldo Cruz. 2009 Mar;104(2):234-40. Review.

PMID:
19430648
[PubMed - indexed for MEDLINE]
Free Article
9.

Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death.

Zhao YO, Khaminets A, Hunn JP, Howard JC.

PLoS Pathog. 2009 Feb;5(2):e1000288. doi: 10.1371/journal.ppat.1000288. Epub 2009 Feb 6.

PMID:
19197351
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Balance of Irgm protein activities determines IFN-gamma-induced host defense.

Henry SC, Daniell XG, Burroughs AR, Indaram M, Howell DN, Coers J, Starnbach MN, Hunn JP, Howard JC, Feng CG, Sher A, Taylor GA.

J Leukoc Biol. 2009 May;85(5):877-85. doi: 10.1189/jlb.1008599. Epub 2009 Jan 27.

PMID:
19176402
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Inactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivo.

Papic N, Hunn JP, Pawlowski N, Zerrahn J, Howard JC.

J Biol Chem. 2008 Nov 14;283(46):32143-51. doi: 10.1074/jbc.M804846200. Epub 2008 Sep 10.

PMID:
18784077
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii.

Hunn JP, Koenen-Waisman S, Papic N, Schroeder N, Pawlowski N, Lange R, Kaiser F, Zerrahn J, Martens S, Howard JC.

EMBO J. 2008 Oct 8;27(19):2495-509. doi: 10.1038/emboj.2008.176. Epub 2008 Sep 4.

PMID:
18772884
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.

Bekpen C, Hunn JP, Rohde C, Parvanova I, Guethlein L, Dunn DM, Glowalla E, Leptin M, Howard JC.

Genome Biol. 2005;6(11):R92. Epub 2005 Oct 31.

PMID:
16277747
[PubMed - indexed for MEDLINE]
Free PMC Article

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