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Items: 1 to 20 of 48

1.

Toward more predictive genetic mouse models of Alzheimer's disease.

Onos KD, Sukoff Rizzo SJ, Howell GR, Sasner M.

Brain Res Bull. 2015 Dec 17;122:1-11. doi: 10.1016/j.brainresbull.2015.12.003. [Epub ahead of print] Review.

2.

Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.

Berry RH, Qu J, John SW, Howell GR, Jakobs TC.

PLoS One. 2015 Dec 4;10(12):e0144341. doi: 10.1371/journal.pone.0144341. eCollection 2015.

3.

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.

Soto I, Graham LC, Richter HJ, Simeone SN, Radell JE, Grabowska W, Funkhouser WK, Howell MC, Howell GR.

PLoS Biol. 2015 Oct 29;13(10):e1002279. doi: 10.1371/journal.pbio.1002279. eCollection 2015 Oct.

4.

Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.

Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT.

Exp Eye Res. 2015 Dec;141:42-56. doi: 10.1016/j.exer.2015.06.019. Epub 2015 Jun 24. Review.

PMID:
26116903
5.

Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, Nakano S, Uebe S, Harder JM, Chan AS, Lee MC, Burdon KP, Astakhov YS, Abu-Amero KK, Zenteno JC, Nilgün Y, Zarnowski T, Pakravan M, Safieh LA, Jia L, Wang YX, Williams S, Paoli D, Schlottmann PG, Huang L, Sim KS, Foo JN, Nakano M, Ikeda Y, Kumar RS, Ueno M, Manabe S, Hayashi K, Kazama S, Ideta R, Mori Y, Miyata K, Sugiyama K, Higashide T, Chihara E, Inoue K, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Aihara M, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Matsuda F, Yamashiro K, Gotoh N, Miyake M, Astakhov SY, Osman EA, Al-Obeidan SA, Owaidhah O, Al-Jasim L, Shahwan SA, Fogarty RA, Leo P, Yetkin Y, Oğuz Ç, Kanavi MR, Beni AN, Yazdani S, Akopov EL, Toh KY, Howell GR, Orr AC, Goh Y, Meah WY, Peh SQ, Kosior-Jarecka E, Lukasik U, Krumbiegel M, Vithana EN, Wong TY, Liu Y, Koch AE, Challa P, Rautenbach RM, Mackey DA, Hewitt AW, Mitchell P, Wang JJ, Ziskind A, Carmichael T, Ramakrishnan R, Narendran K, Venkatesh R, Vijayan S, Zhao P, Chen X, Guadarrama-Vallejo D, Cheng CY, Perera SA, Husain R, Ho SL, Welge-Luessen UC, Mardin C, Schloetzer-Schrehardt U, Hillmer AM, Herms S, Moebus S, Nöthen MM, Weisschuh N, Shetty R, Ghosh A, Teo YY, Brown MA, Lischinsky I; Blue Mountains Eye Study GWAS Team; Wellcome Trust Case Control Consortium 2, Crowston JG, Coote M, Zhao B, Sang J, Zhang N, You Q, Vysochinskaya V, Founti P, Chatzikyriakidou A, Lambropoulos A, Anastasopoulos E, Coleman AL, Wilson MR, Rhee DJ, Kang JH, May-Bolchakova I, Heegaard S, Mori K, Alward WL, Jonas JB, Xu L, Liebmann JM, Chowbay B, Schaeffeler E, Schwab M, Lerner F, Wang N, Yang Z, Frezzotti P, Kinoshita S, Fingert JH, Inatani M, Tashiro K, Reis A, Edward DP, Pasquale LR, Kubota T, Wiggs JL, Pasutto F, Topouzis F, Dubina M, Craig JE, Yoshimura N, Sundaresan P, John SW, Ritch R, Hauser MA, Khor CC.

Nat Genet. 2015 Jun;47(6):689. doi: 10.1038/ng0615-689c. No abstract available.

PMID:
26018902
6.

DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.

Jackson HM, Onos KD, Pepper KW, Graham LC, Akeson EC, Byers C, Reinholdt LG, Frankel WN, Howell GR.

PLoS One. 2015 May 1;10(5):e0125897. doi: 10.1371/journal.pone.0125897. eCollection 2015.

7.

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT.

J Exp Med. 2015 Mar 9;212(3):287-95. doi: 10.1084/jem.20142322. Epub 2015 Mar 2.

8.

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, Nakano S, Uebe S, Harder JM, Chan AS, Lee MC, Burdon KP, Astakhov YS, Abu-Amero KK, Zenteno JC, Nilgün Y, Zarnowski T, Pakravan M, Safieh LA, Jia L, Wang YX, Williams S, Paoli D, Schlottmann PG, Huang L, Sim KS, Foo JN, Nakano M, Ikeda Y, Kumar RS, Ueno M, Manabe S, Hayashi K, Kazama S, Ideta R, Mori Y, Miyata K, Sugiyama K, Higashide T, Chihara E, Inoue K, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Aihara M, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Matsuda F, Yamashiro K, Gotoh N, Miyake M, Astakhov SY, Osman EA, Al-Obeidan SA, Owaidhah O, Al-Jasim L, Al Shahwan S, Fogarty RA, Leo P, Yetkin Y, Oğuz Ç, Kanavi MR, Beni AN, Yazdani S, Akopov EL, Toh KY, Howell GR, Orr AC, Goh Y, Meah WY, Peh SQ, Kosior-Jarecka E, Lukasik U, Krumbiegel M, Vithana EN, Wong TY, Liu Y, Koch AE, Challa P, Rautenbach RM, Mackey DA, Hewitt AW, Mitchell P, Wang JJ, Ziskind A, Carmichael T, Ramakrishnan R, Narendran K, Venkatesh R, Vijayan S, Zhao P, Chen X, Guadarrama-Vallejo D, Cheng CY, Perera SA, Husain R, Ho SL, Welge-Luessen UC, Mardin C, Schloetzer-Schrehardt U, Hillmer AM, Herms S, Moebus S, Nöthen MM, Weisschuh N, Shetty R, Ghosh A, Teo YY, Brown MA, Lischinsky I; Blue Mountains Eye Study GWAS Team; Wellcome Trust Case Control Consortium 2, Crowston JG, Coote M, Zhao B, Sang J, Zhang N, You Q, Vysochinskaya V, Founti P, Chatzikyriakidou A, Lambropoulos A, Anastasopoulos E, Coleman AL, Wilson MR, Rhee DJ, Kang JH, May-Bolchakova I, Heegaard S, Mori K, Alward WL, Jonas JB, Xu L, Liebmann JM, Chowbay B, Schaeffeler E, Schwab M, Lerner F, Wang N, Yang Z, Frezzotti P, Kinoshita S, Fingert JH, Inatani M, Tashiro K, Reis A, Edward DP, Pasquale LR, Kubota T, Wiggs JL, Pasutto F, Topouzis F, Dubina M, Craig JE, Yoshimura N, Sundaresan P, John SW, Ritch R, Hauser MA, Khor CC.

Nat Genet. 2015 Apr;47(4):387-92. doi: 10.1038/ng.3226. Epub 2015 Feb 23. Erratum in: Nat Genet. 2015 Jun;47(6):689.

9.

DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.

Soto I, Howell GR, John CW, Kief JL, Libby RT, John SW.

PLoS One. 2014 Sep 10;9(9):e107291. doi: 10.1371/journal.pone.0107291. eCollection 2014.

10.

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma.

Howell GR, MacNicoll KH, Braine CE, Soto I, Macalinao DG, Sousa GL, John SW.

Neurobiol Dis. 2014 Nov;71:44-52. doi: 10.1016/j.nbd.2014.07.016. Epub 2014 Aug 15.

11.

The complex role of neuroinflammation in glaucoma.

Soto I, Howell GR.

Cold Spring Harb Perspect Med. 2014 Jul 3;4(8). pii: a017269. doi: 10.1101/cshperspect.a017269. Review.

PMID:
24993677
12.

A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].

Cross SH, Macalinao DG, McKie L, Rose L, Kearney AL, Rainger J, Thaung C, Keighren M, Jadeja S, West K, Kneeland SC, Smith RS, Howell GR, Young F, Robertson M, van T' Hof R, John SW, Jackson IJ.

PLoS Genet. 2014 May 8;10(5):e1004359. doi: 10.1371/journal.pgen.1004359. eCollection 2014 May. Erratum in: PLoS Genet. 2014 Dec;10(12):e1004917.

13.

Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.

Jackson HM, Soto I, Graham LC, Carter GW, Howell GR.

BMC Genomics. 2013 Nov 25;14:831. doi: 10.1186/1471-2164-14-831.

14.

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma.

Williams PA, Howell GR, Barbay JM, Braine CE, Sousa GL, John SW, Morgan JE.

PLoS One. 2013 Aug 19;8(8):e72282. doi: 10.1371/journal.pone.0072282. eCollection 2013.

15.

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.

Howell GR, Soto I, Ryan M, Graham LC, Smith RS, John SW.

J Neuroinflammation. 2013 Jun 27;10:76. doi: 10.1186/1742-2094-10-76.

16.

Adding metabolomics to the toolbox for studying retinal disease.

Howell GR, Libby RT.

Invest Ophthalmol Vis Sci. 2013 Jun 21;54(6):4260. doi: 10.1167/iovs.13-12479. No abstract available.

PMID:
23794537
17.

Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.

Wiggs JL, Howell GR, Linkroum K, Abdrabou W, Hodges E, Braine CE, Pasquale LR, Hannon GJ, Haines JL, John SW.

Clin Genet. 2013 Aug;84(2):167-74. doi: 10.1111/cge.12176. Epub 2013 May 27.

18.

Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases.

Reinholdt LG, Howell GR, Czechanski AM, Macalinao DG, Macnicoll KH, Lin CS, Donahue LR, John SW.

PLoS One. 2012;7(11):e50081. doi: 10.1371/journal.pone.0050081. Epub 2012 Nov 27.

19.

High throughput sequencing approaches to mutation discovery in the mouse.

Simon MM, Mallon AM, Howell GR, Reinholdt LG.

Mamm Genome. 2012 Oct;23(9-10):499-513. doi: 10.1007/s00335-012-9424-0. Epub 2012 Sep 19. Review.

20.

Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy.

Nickells RW, Howell GR, Soto I, John SW.

Annu Rev Neurosci. 2012;35:153-79. doi: 10.1146/annurev.neuro.051508.135728. Epub 2012 Apr 12. Review.

PMID:
22524788
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