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Results: 1 to 20 of 39

1.

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma.

Howell GR, MacNicoll KH, Braine CE, Soto I, Macalinao DG, Sousa GL, John SW.

Neurobiol Dis. 2014 Aug 15. pii: S0969-9961(14)00238-1. doi: 10.1016/j.nbd.2014.07.016. [Epub ahead of print]

PMID:
25132557
[PubMed - as supplied by publisher]
2.

The Complex Role of Neuroinflammation in Glaucoma.

Soto I, Howell GR.

Cold Spring Harb Perspect Med. 2014 Jul 3;4(8). pii: a017269. doi: 10.1101/cshperspect.a017269. Review.

PMID:
24993677
[PubMed - as supplied by publisher]
3.

A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LBD1-mediated dimerisation.

Cross SH, Macalinao DG, McKie L, Rose L, Kearney AL, Rainger J, Thaung C, Keighren M, Jadeja S, West K, Kneeland SC, Smith RS, Howell GR, Young F, Robertson M, van T' Hof R, John SW, Jackson IJ.

PLoS Genet. 2014 May 8;10(5):e1004359. doi: 10.1371/journal.pgen.1004359. eCollection 2014 May.

PMID:
24809698
[PubMed - in process]
Free PMC Article
4.

Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.

Jackson HM, Soto I, Graham LC, Carter GW, Howell GR.

BMC Genomics. 2013 Nov 25;14:831. doi: 10.1186/1471-2164-14-831.

PMID:
24274089
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma.

Williams PA, Howell GR, Barbay JM, Braine CE, Sousa GL, John SW, Morgan JE.

PLoS One. 2013 Aug 19;8(8):e72282. doi: 10.1371/journal.pone.0072282. eCollection 2013.

PMID:
23977271
[PubMed - in process]
Free PMC Article
6.

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.

Howell GR, Soto I, Ryan M, Graham LC, Smith RS, John SW.

J Neuroinflammation. 2013 Jun 27;10(1):76. doi: 10.1186/1742-2094-10-76.

PMID:
23806181
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Adding metabolomics to the toolbox for studying retinal disease.

Howell GR, Libby RT.

Invest Ophthalmol Vis Sci. 2013 Jun 21;54(6):4260. doi: 10.1167/iovs.13-12479. No abstract available.

PMID:
23794537
[PubMed - indexed for MEDLINE]
Free Article
8.

Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.

Wiggs JL, Howell GR, Linkroum K, Abdrabou W, Hodges E, Braine CE, Pasquale LR, Hannon GJ, Haines JL, John SW.

Clin Genet. 2013 Aug;84(2):167-74. doi: 10.1111/cge.12176. Epub 2013 May 27.

PMID:
23621901
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases.

Reinholdt LG, Howell GR, Czechanski AM, Macalinao DG, Macnicoll KH, Lin CS, Donahue LR, John SW.

PLoS One. 2012;7(11):e50081. doi: 10.1371/journal.pone.0050081. Epub 2012 Nov 27.

PMID:
23209647
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

High throughput sequencing approaches to mutation discovery in the mouse.

Simon MM, Mallon AM, Howell GR, Reinholdt LG.

Mamm Genome. 2012 Oct;23(9-10):499-513. doi: 10.1007/s00335-012-9424-0. Epub 2012 Sep 19. Review.

PMID:
22991087
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy.

Nickells RW, Howell GR, Soto I, John SW.

Annu Rev Neurosci. 2012;35:153-79. doi: 10.1146/annurev.neuro.051508.135728. Epub 2012 Apr 12. Review.

PMID:
22524788
[PubMed - indexed for MEDLINE]
12.

Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.

Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, MacNicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SW.

J Clin Invest. 2012 Apr 2;122(4):1246-61. doi: 10.1172/JCI61135. Epub 2012 Mar 19.

PMID:
22426214
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Intrinsic axonal degeneration pathways are critical for glaucomatous damage.

Howell GR, Soto I, Libby RT, John SW.

Exp Neurol. 2013 Aug;246:54-61. doi: 10.1016/j.expneurol.2012.01.014. Epub 2012 Jan 18. Review.

PMID:
22285251
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data.

Howell GR, Walton DO, King BL, Libby RT, John SW.

BMC Genomics. 2011 Aug 24;12:429. doi: 10.1186/1471-2164-12-429.

PMID:
21864367
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.

Nair KS, Hmani-Aifa M, Ali Z, Kearney AL, Ben Salem S, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SW.

Nat Genet. 2011 Jun;43(6):579-84. doi: 10.1038/ng.813. Epub 2011 May 1.

PMID:
21532570
[PubMed - indexed for MEDLINE]
16.

Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.

Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL.

Science. 2011 Mar 25;331(6024):1571-6. doi: 10.1126/science.1195970.

PMID:
21436445
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.

Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SW.

J Clin Invest. 2011 Apr;121(4):1429-44. doi: 10.1172/JCI44646. Epub 2011 Mar 7.

PMID:
21383504
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection.

Howell GR, Libby RT, John SW.

Prog Brain Res. 2008;173:303-21. doi: 10.1016/S0079-6123(08)01122-9.

PMID:
18929118
[PubMed - indexed for MEDLINE]
19.

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.

Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SW.

J Cell Biol. 2007 Dec 31;179(7):1523-37. Epub 2007 Dec 24.

PMID:
18158332
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model.

Libby RT, Howell GR, Pang IH, Savinova OV, Mehalow AK, Barter JW, Smith RS, Clark AF, John SW.

BMC Neurosci. 2007 Dec 19;8:108.

PMID:
18093296
[PubMed - indexed for MEDLINE]
Free PMC Article

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