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Results: 1 to 20 of 68

1.

Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension.

Trenkwalder C, Beneš H, Grote L, García-Borreguero D, Högl B, Hopp M, Bosse B, Oksche A, Reimer K, Winkelmann J, Allen RP, Kohnen R; RELOXYN Study Group.

Lancet Neurol. 2013 Dec;12(12):1141-50. doi: 10.1016/S1474-4422(13)70239-4. Epub 2013 Oct 18. Erratum in: Lancet Neurol. 2013 Dec;12(12):1133.

PMID:
24140442
[PubMed - indexed for MEDLINE]
2.

Low absolute bioavailability of oral naloxone in healthy subjects.

Smith K, Hopp M, Mundin G, Bond S, Bailey P, Woodward J, Bell D.

Int J Clin Pharmacol Ther. 2012 May;50(5):360-7.

PMID:
22541841
[PubMed - indexed for MEDLINE]
3.

A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain.

Ahmedzai SH, Nauck F, Bar-Sela G, Bosse B, Leyendecker P, Hopp M.

Palliat Med. 2012 Jan;26(1):50-60. doi: 10.1177/0269216311418869. Epub 2011 Sep 21.

PMID:
21937568
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Cardiac disease in methylmalonic acidemia.

Prada CE, Al Jasmi F, Kirk EP, Hopp M, Jones O, Leslie ND, Burrow TA.

J Pediatr. 2011 Nov;159(5):862-4. doi: 10.1016/j.jpeds.2011.06.005. Epub 2011 Jul 23.

PMID:
21784454
[PubMed - indexed for MEDLINE]
5.

Naloxone as part of a prolonged release oxycodone/naloxone combination reduces oxycodone-induced slowing of gastrointestinal transit in healthy volunteers.

Smith K, Hopp M, Mundin G, Bond S, Bailey P, Woodward J, Palaniappan K, Church A, Limb M, Connor A.

Expert Opin Investig Drugs. 2011 Apr;20(4):427-39. doi: 10.1517/13543784.2011.563236.

PMID:
21395483
[PubMed - indexed for MEDLINE]
6.

Observational, nonintervention, multicenter study for validation of the Bowel Function Index for constipation in European countries.

Rentz AM, van Hanswijck de Jonge P, Leyendecker P, Hopp M.

Curr Med Res Opin. 2011 Jan;27(1):35-44. doi: 10.1185/03007995.2010.535270. Epub 2010 Nov 18.

PMID:
21083515
[PubMed - indexed for MEDLINE]
7.

Efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of moderate/severe chronic non-malignant pain: results of a prospectively designed pooled analysis of two randomised, double-blind clinical trials.

Löwenstein O, Leyendecker P, Lux EA, Blagden M, Simpson KH, Hopp M, Bosse B, Reimer K.

BMC Clin Pharmacol. 2010 Sep 29;10:12. doi: 10.1186/1472-6904-10-12.

PMID:
20920236
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain.

Sandner-Kiesling A, Leyendecker P, Hopp M, Tarau L, Lejcko J, Meissner W, Sevcik P, Hakl M, Hrib R, Uhl R, Dürr H, Reimer K.

Int J Clin Pract. 2010 May;64(6):763-74. doi: 10.1111/j.1742-1241.2010.02360.x. Epub 2010 Mar 29.

PMID:
20370845
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Opioid-induced bowel dysfunction in cancer-related pain: causes, consequences, and a novel approach for its management.

Holzer P, Ahmedzai SH, Niederle N, Leyendecker P, Hopp M, Bosse B, Spohr I, Reimer K.

J Opioid Manag. 2009 May-Jun;5(3):145-51. Review.

PMID:
19662924
[PubMed - indexed for MEDLINE]
10.

Combined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trial.

Löwenstein O, Leyendecker P, Hopp M, Schutter U, Rogers PD, Uhl R, Bond S, Kremers W, Nichols T, Krain B, Reimer K.

Expert Opin Pharmacother. 2009 Mar;10(4):531-43. doi: 10.1517/14656560902796798 .

PMID:
19243306
[PubMed - indexed for MEDLINE]
11.

Single- and multiple-dose pharmacokinetic evaluation of oxycodone and naloxone in an opioid agonist/antagonist prolonged-release combination in healthy adult volunteers.

Smith K, Hopp M, Mundin G, Leyendecker P, Bailey P, Grothe B, Uhl R, Reimer K.

Clin Ther. 2008 Nov;30(11):2051-68. doi: 10.1016/j.clinthera.2008.11.008.

PMID:
19108793
[PubMed - indexed for MEDLINE]
12.

Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain.

Simpson K, Leyendecker P, Hopp M, Müller-Lissner S, Löwenstein O, De Andrés J, Troy Ferrarons J, Bosse B, Krain B, Nichols T, Kremers W, Reimer K.

Curr Med Res Opin. 2008 Dec;24(12):3503-12. doi: 10.1185/03007990802584454 .

PMID:
19032132
[PubMed - indexed for MEDLINE]
13.

Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approach.

Reimer K, Hopp M, Zenz M, Maier C, Holzer P, Mikus G, Bosse B, Smith K, Buschmann-Kramm C, Leyendecker P.

Pharmacology. 2009;83(1):10-7. doi: 10.1159/000165778. Epub 2008 Oct 28. Review.

PMID:
18957874
[PubMed - indexed for MEDLINE]
14.

A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation.

Meissner W, Leyendecker P, Mueller-Lissner S, Nadstawek J, Hopp M, Ruckes C, Wirz S, Fleischer W, Reimer K.

Eur J Pain. 2009 Jan;13(1):56-64. doi: 10.1016/j.ejpain.2008.06.012. Epub 2008 Aug 31.

PMID:
18762438
[PubMed - indexed for MEDLINE]
15.

Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain.

Vondrackova D, Leyendecker P, Meissner W, Hopp M, Szombati I, Hermanns K, Ruckes C, Weber S, Grothe B, Fleischer W, Reimer K.

J Pain. 2008 Dec;9(12):1144-54. doi: 10.1016/j.jpain.2008.06.014. Epub 2008 Aug 16.

PMID:
18708300
[PubMed - indexed for MEDLINE]
16.

Patient assessment of a novel therapeutic approach for the treatment of severe, chronic pain.

Nadstawek J, Leyendecker P, Hopp M, Ruckes C, Wirz S, Fleischer W, Reimer K.

Int J Clin Pract. 2008 Aug;62(8):1159-67. doi: 10.1111/j.1742-1241.2008.01820.x.

PMID:
18705820
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

[Local therapy of grade IIa burns: efficacy and tolerability of a new hydrosome wound gel for the local treatment of grade IIa burns as compared with silver sulfadiazine ointment].

Hauser J, Rossbach O, Langer S, Vogt P, Germann G, Steinau HU, Reimer K, Hopp M, Langer-Brauburger B, Bosse B, Homann HH.

Unfallchirurg. 2007 Nov;110(11):988-94. German.

PMID:
17989948
[PubMed - indexed for MEDLINE]
18.

Extended follow-up of palatal implants for OSA treatment.

Walker RP, Levine HL, Hopp ML, Greene D.

Otolaryngol Head Neck Surg. 2007 Nov;137(5):822-7.

PMID:
17967653
[PubMed - indexed for MEDLINE]
19.

A liposome hydrogel with polyvinyl-pyrrolidone iodine in the local treatment of partial-thickness burn wounds.

Homann HH, Rosbach O, Moll W, Vogt PM, Germann G, Hopp M, Langer-Brauburger B, Reimer K, Steinau HU.

Ann Plast Surg. 2007 Oct;59(4):423-7.

PMID:
17901735
[PubMed - indexed for MEDLINE]
20.

Palatal implants: a new approach for the treatment of obstructive sleep apnea.

Walker RP, Levine HL, Hopp ML, Greene D, Pang K.

Otolaryngol Head Neck Surg. 2006 Oct;135(4):549-54.

PMID:
17011415
[PubMed - indexed for MEDLINE]

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