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Modeling the antiferromagnetic MnIIMnII system within the protein phosphatase-5 catalytic site.

Salter EA, Honkanen RE, Wierzbicki A.

J Mol Model. 2015 Jan;21(1):2556. doi: 10.1007/s00894-014-2556-2. Epub 2015 Jan 24.


Protein phosphatases in pancreatic islets.

Ortsäter H, Grankvist N, Honkanen RE, Sjöholm Å.

J Endocrinol. 2014 Jun;221(3):R121-44. doi: 10.1530/JOE-14-0002. Epub 2014 Mar 28. Review.


Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.

Mazalouskas MD, Godoy-Ruiz R, Weber DJ, Zimmer DB, Honkanen RE, Wadzinski BE.

J Biol Chem. 2014 Feb 14;289(7):4219-32. doi: 10.1074/jbc.M113.518514. Epub 2013 Dec 26.


Mitogen-activated protein kinases and protein phosphatase 5 mediate glucocorticoid-induced cytotoxicity in pancreatic islets and β-cells.

Fransson L, Rosengren V, Saha TK, Grankvist N, Islam T, Honkanen RE, Sjöholm Å, Ortsäter H.

Mol Cell Endocrinol. 2014 Mar 5;383(1-2):126-36. doi: 10.1016/j.mce.2013.12.010. Epub 2013 Dec 20.


Genetic disruption of protein phosphatase 5 in mice prevents high-fat diet feeding-induced weight gain.

Grankvist N, Honkanen RE, Sjöholm Å, Ortsäter H.

FEBS Lett. 2013 Nov 29;587(23):3869-74. doi: 10.1016/j.febslet.2013.10.022. Epub 2013 Oct 26.


Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death.

Theobald B, Bonness K, Musiyenko A, Andrews JF, Urban G, Huang X, Dean NM, Honkanen RE.

Mol Cancer Res. 2013 Aug;11(8):845-55. doi: 10.1158/1541-7786.MCR-13-0032. Epub 2013 May 13.


Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells.

Henesy MB, Britain AL, Zhu B, Amable L, Honkanen RE, Corbin JD, Francis SH, Rich TC.

PLoS One. 2012;7(8):e41711. doi: 10.1371/journal.pone.0041711. Epub 2012 Aug 2.


Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases.

Bouazza B, Krytska K, Debba-Pavard M, Amrani Y, Honkanen RE, Tran J, Tliba O.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):464-73. doi: 10.1165/rcmb.2011-0364OC. Epub 2012 May 16.


Serine/threonine protein phosphatase 5 regulates glucose homeostasis in vivo and apoptosis signalling in mouse pancreatic islets and clonal MIN6 cells.

Grankvist N, Amable L, Honkanen RE, Sjöholm A, Ortsäter H.

Diabetologia. 2012 Jul;55(7):2005-15. doi: 10.1007/s00125-012-2541-1. Epub 2012 Apr 12.


DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.

Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA, Samant RS.

Oncogene. 2012 Oct 11;31(41):4472-83. doi: 10.1038/onc.2011.623. Epub 2012 Jan 23.


Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).

Amable L, Grankvist N, Largen JW, Ortsäter H, Sjöholm Å, Honkanen RE.

J Biol Chem. 2011 Nov 25;286(47):40413-22. doi: 10.1074/jbc.M111.244053. Epub 2011 Sep 15.


Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity.

Yang X, Liu Y, Yang XM, Hu F, Cui L, Swingle MR, Honkanen RE, Soltani P, Tissier R, Cohen MV, Downey JM.

Basic Res Cardiol. 2011 May;106(3):421-30. doi: 10.1007/s00395-011-0165-0. Epub 2011 Mar 12.


Modulation of protein phosphatase 2A activity alters androgen-independent growth of prostate cancer cells: therapeutic implications.

Bhardwaj A, Singh S, Srivastava SK, Honkanen RE, Reed E, Singh AP.

Mol Cancer Ther. 2011 May;10(5):720-31. doi: 10.1158/1535-7163.MCT-10-1096. Epub 2011 Mar 10.


Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5.

Skarra DV, Goudreault M, Choi H, Mullin M, Nesvizhskii AI, Gingras AC, Honkanen RE.

Proteomics. 2011 Apr;11(8):1508-16. doi: 10.1002/pmic.201000770. Epub 2011 Feb 25.


Total synthesis and evaluation of phostriecin and key structural analogues.

Burke CP, Swingle MR, Honkanen RE, Boger DL.

J Org Chem. 2010 Nov 19;75(22):7505-13. doi: 10.1021/jo1010203. Epub 2010 Jul 29.


Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors.

Swingle MR, Amable L, Lawhorn BG, Buck SB, Burke CP, Ratti P, Fischer KL, Boger DL, Honkanen RE.

J Pharmacol Exp Ther. 2009 Oct;331(1):45-53. doi: 10.1124/jpet.109.155630. Epub 2009 Jul 10.


Human DNA polymerase eta activity and translocation is regulated by phosphorylation.

Chen YW, Cleaver JE, Hatahet Z, Honkanen RE, Chang JY, Yen Y, Chou KM.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16578-83. doi: 10.1073/pnas.0808589105. Epub 2008 Oct 22.


Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.

Golden T, Aragon IV, Rutland B, Tucker JA, Shevde LA, Samant RS, Zhou G, Amable L, Skarra D, Honkanen RE.

Biochim Biophys Acta. 2008 Apr;1782(4):259-70. doi: 10.1016/j.bbadis.2008.01.004. Epub 2008 Jan 26.


The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer.

Golden T, Swingle M, Honkanen RE.

Cancer Metastasis Rev. 2008 Jun;27(2):169-78. doi: 10.1007/s10555-008-9125-z. Review.

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