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Results: 1 to 20 of 37

1.

The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure.

Talikka M, Kostadinova R, Xiang Y, Mathis C, Sewer A, Majeed S, Kuehn D, Frentzel S, Merg C, Geertz M, Martin F, Ivanov NV, Peitsch MC, Hoeng J.

Int J Toxicol. 2014 Oct 8. pii: 1091581814551647. [Epub ahead of print]

PMID:
25297719
[PubMed - as supplied by publisher]
2.

A crowd-sourcing approach for the construction of species-specific cell signaling networks.

Bilal E, Sakellaropoulos T, Participants C, Melas IN, Messinis DE, Belcastro V, Rhrissorrakrai K, Meyer P, Norel R, Iskandar A, Blaese E, Rice JJ, Peitsch MC, Hoeng J, Stolovitzky G, Alexopoulos LG, Poussin C.

Bioinformatics. 2014 Oct 7. pii: btu659. [Epub ahead of print]

PMID:
25294919
[PubMed - as supplied by publisher]
Free Article
3.

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge.

Rhrissorrakrai K, Belcastro V, Bilal E, Norel R, Poussin C, Mathis C, Dulize RH, Ivanov NV, Alexopoulos L, Rice JJ, Peitsch M, Stolovitzky G, Meyer P, Hoeng J.

Bioinformatics. 2014 Sep 17. pii: btu611. [Epub ahead of print]

PMID:
25236459
[PubMed - as supplied by publisher]
Free Article
4.

CSEO - the Cigarette Smoke Exposure Ontology.

Younesi E, Ansari S, Guendel M, Ahmadi S, Coggins C, Hoeng J, Hofmann-Apitius M, Peitsch MC.

J Biomed Semantics. 2014 Jul 10;5:31. doi: 10.1186/2041-1480-5-31. eCollection 2014.

PMID:
25093069
[PubMed]
Free PMC Article
5.

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures.

Schlage WK, Iskandar AR, Kostadinova R, Xiang Y, Sewer A, Majeed S, Kuehn D, Frentzel S, Talikka M, Geertz M, Mathis C, Ivanov N, Hoeng J, Peitsch MC.

Toxicol Mech Methods. 2014 Oct;24(7):470-87. doi: 10.3109/15376516.2014.943441. Epub 2014 Sep 11.

PMID:
25046638
[PubMed - in process]
6.

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models.

Martin F, Sewer A, Talikka M, Xiang Y, Hoeng J, Peitsch MC.

BMC Bioinformatics. 2014 Jul 11;15:238. doi: 10.1186/1471-2105-15-238.

PMID:
25015298
[PubMed - indexed for MEDLINE]
Free Article
7.

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability.

De León H, Boué S, Schlage WK, Boukharov N, Westra JW, Gebel S, VanHooser A, Talikka M, Fields RB, Veljkovic E, Peck MJ, Mathis C, Hoang V, Poussin C, Deehan R, Stolle K, Hoeng J, Peitsch MC.

J Transl Med. 2014 Jun 26;12:185. doi: 10.1186/1479-5876-12-185.

PMID:
24965703
[PubMed - in process]
Free Article
8.

Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression.

Sewer A, Gubian S, Kogel U, Veljkovic E, Han W, Hengstermann A, Peitsch MC, Hoeng J.

BMC Res Notes. 2014 May 17;7:302. doi: 10.1186/1756-0500-7-302.

PMID:
24886675
[PubMed - in process]
Free PMC Article
9.

Mechanism of an indirect effect of aqueous cigarette smoke extract on the adhesion of monocytic cells to endothelial cells in an in vitro assay revealed by transcriptomics analysis.

Poussin C, Gallitz I, Schlage WK, Steffen Y, Stolle K, Lebrun S, Hoeng J, Peitsch MC, Lietz M.

Toxicol In Vitro. 2014 Aug;28(5):896-908. doi: 10.1016/j.tiv.2014.03.005. Epub 2014 Apr 18.

PMID:
24747719
[PubMed - in process]
Free Article
10.

A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

Kogel U, Schlage WK, Martin F, Xiang Y, Ansari S, Leroy P, Vanscheeuwijck P, Gebel S, Buettner A, Wyss C, Esposito M, Hoeng J, Peitsch MC.

Food Chem Toxicol. 2014 Jun;68:204-17. doi: 10.1016/j.fct.2014.02.034. Epub 2014 Mar 12.

PMID:
24632068
[PubMed - in process]
Free Article
11.

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™).

Xiang Y, Kogel U, Gebel S, Peck MJ, Peitsch MC, Akmaev VR, Hoeng J.

Gene Regul Syst Bio. 2014 Feb 19;8:45-61. doi: 10.4137/GRSB.S13140. eCollection 2014.

PMID:
24596455
[PubMed]
Free PMC Article
12.

Systems toxicology: from basic research to risk assessment.

Sturla SJ, Boobis AR, FitzGerald RE, Hoeng J, Kavlock RJ, Schirmer K, Whelan M, Wilks MF, Peitsch MC.

Chem Res Toxicol. 2014 Mar 17;27(3):314-29. doi: 10.1021/tx400410s. Epub 2014 Jan 21.

PMID:
24446777
[PubMed - in process]
Free PMC Article
13.

Systems biology approach for evaluating the biological impact of environmental toxicants in vitro.

Gonzalez-Suarez I, Sewer A, Walker P, Mathis C, Ellis S, Woodhouse H, Guedj E, Dulize R, Marescotti D, Acali S, Martin F, Ivanov NV, Hoeng J, Peitsch MC.

Chem Res Toxicol. 2014 Mar 17;27(3):367-76. doi: 10.1021/tx400405s. Epub 2014 Jan 30.

PMID:
24428674
[PubMed - in process]
14.

Systems approaches evaluating the perturbation of xenobiotic metabolism in response to cigarette smoke exposure in nasal and bronchial tissues.

Iskandar AR, Martin F, Talikka M, Schlage WK, Kostadinova R, Mathis C, Hoeng J, Peitsch MC.

Biomed Res Int. 2013;2013:512086. doi: 10.1155/2013/512086. Epub 2013 Oct 3.

PMID:
24224167
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

On Crowd-verification of Biological Networks.

sbv IMPROVER project team (in alphabetical order), Ansari S, Binder J, Boue S, Di Fabio A, Hayes W, Hoeng J, Iskandar A, Kleiman R, Norel R, O'Neel B, Peitsch MC, Poussin C, Pratt D, Rhrissorrakrai K, Schlage WK, Stolovitzky G, Talikka M.

Bioinform Biol Insights. 2013 Oct 10;7:307-25. doi: 10.4137/BBI.S12932. eCollection 2013.

PMID:
24151423
[PubMed]
Free PMC Article
16.

Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation.

Boué S, De León H, Schlage WK, Peck MJ, Weiler H, Berges A, Vuillaume G, Martin F, Friedrichs B, Lebrun S, Meurrens K, Schracke N, Moehring M, Steffen Y, Schueller J, Vanscheeuwijck P, Peitsch MC, Hoeng J.

Toxicology. 2013 Dec 6;314(1):112-24. doi: 10.1016/j.tox.2013.09.013. Epub 2013 Oct 1.

PMID:
24096154
[PubMed - indexed for MEDLINE]
Free Article
17.

Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge.

Tarca AL, Lauria M, Unger M, Bilal E, Boue S, Kumar Dey K, Hoeng J, Koeppl H, Martin F, Meyer P, Nandy P, Norel R, Peitsch M, Rice JJ, Romero R, Stolovitzky G, Talikka M, Xiang Y, Zechner C; IMPROVER DSC Collaborators.

Bioinformatics. 2013 Nov 15;29(22):2892-9. doi: 10.1093/bioinformatics/btt492. Epub 2013 Aug 20.

PMID:
23966112
[PubMed - indexed for MEDLINE]
18.

Case study: the role of mechanistic network models in systems toxicology.

Hoeng J, Talikka M, Martin F, Sewer A, Yang X, Iskandar A, Schlage WK, Peitsch MC.

Drug Discov Today. 2014 Feb;19(2):183-92. doi: 10.1016/j.drudis.2013.07.023. Epub 2013 Aug 9.

PMID:
23933191
[PubMed - in process]
19.

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models.

Thomson TM, Sewer A, Martin F, Belcastro V, Frushour BP, Gebel S, Park J, Schlage WK, Talikka M, Vasilyev DM, Westra JW, Hoeng J, Peitsch MC.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):863-78. doi: 10.1016/j.taap.2013.07.007. Epub 2013 Aug 8.

PMID:
23933166
[PubMed - indexed for MEDLINE]
Free Article
20.

Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset.

Belcastro V, Poussin C, Gebel S, Mathis C, Schlage WK, Lichtner RB, Quadt-Humme S, Wagner S, Hoeng J, Peitsch MC.

Bioinform Biol Insights. 2013 Jul 23;7:217-30. doi: 10.4137/BBI.S12167. Print 2013.

PMID:
23926424
[PubMed]
Free PMC Article

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