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An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared with Conventional Cigarettes.

Phillips B, Veljkovic E, Boué S, Schlage WK, Vuillaume G, Martin F, Titz B, Leroy P, Buettner A, Elamin A, Oviedo A, Cabanski M, Guedj E, Schneider T, Talikka M, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J.

Toxicol Sci. 2015 Nov 25. pii: kfv243. [Epub ahead of print]


Effects of cigarette smoke, cessation and switching to two heat-not-burn tobacco products on lung lipid metabolism in C57BL/6 and Apoe-/- mice - an integrative systems toxicology analysis.

Titz B, Boué S, Phillips B, Talikka M, Vihervaara T, Schneider T, Nury C, Elamin A, Guedj E, Peck MJ, Schlage WK, Cabanski M, Leroy P, Vuillaume G, Martin F, Ivanov NV, Veljkovic E, Ekroos K, Laaksonen R, Vanscheeuwijck P, Peitsch MC, Hoeng J.

Toxicol Sci. 2015 Nov 17. pii: kfv244. [Epub ahead of print]


Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes.

van der Toorn M, Frentzel S, De Leon H, Goedertier D, Peitsch MC, Hoeng J.

Food Chem Toxicol. 2015 Oct 1;86:81-87. doi: 10.1016/j.fct.2015.09.016. [Epub ahead of print]


Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects.

Titz B, Sewer A, Schneider T, Elamin A, Martin F, Dijon S, Luettich K, Guedj E, Vuillaume G, Ivanov NV, Peck MJ, Chaudhary NI, Hoeng J, Peitsch MC.

J Proteomics. 2015 Oct 14;128:306-20. doi: 10.1016/j.jprot.2015.08.009. Epub 2015 Aug 22.


Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague-Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology.

Phillips B, Esposito M, Verbeeck J, Boué S, Iskandar A, Vuillaume G, Leroy P, Krishnan S, Kogel U, Utan A, Schlage WK, Bera M, Veljkovic E, Hoeng J, Peitsch MC, Vanscheeuwijck P.

Inhal Toxicol. 2015;27(9):405-31. doi: 10.3109/08958378.2015.1046000. Epub 2015 Aug 20.


Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells.

Kogel U, Gonzalez Suarez I, Xiang Y, Dossin E, Guy PA, Mathis C, Marescotti D, Goedertier D, Martin F, Peitsch MC, Hoeng J.

Toxicol In Vitro. 2015 Dec;29(8):2102-15. doi: 10.1016/j.tiv.2015.08.004. Epub 2015 Aug 13.


Construction of biological networks from unstructured information based on a semi-automated curation workflow.

Szostak J, Ansari S, Madan S, Fluck J, Talikka M, Iskandar A, De Leon H, Hofmann-Apitius M, Peitsch MC, Hoeng J.

Database (Oxford). 2015 Jun 17;2015:bav057. doi: 10.1093/database/bav057.


Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion.

Poussin C, Laurent A, Peitsch MC, Hoeng J, De Leon H.

Toxicol Sci. 2015 Oct;147(2):370-85. doi: 10.1093/toxsci/kfv137. Epub 2015 Jul 2.


Systems Biology Research into Cardiovascular Disease: Contributions of Lipidomics-based Approaches to Biomarker Discovery.

De Leon H, Boue S, Szostak J, Peitsch MC, Hoeng J.

Curr Drug Discov Technol. 2015 Sep 16;12(3):129-54.


Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model.

Luettich K, Xiang Y, Iskandar A, Sewer A, Martin F, Talikka M, Vanscheeuwijck P, Berges A, Veljkovic E, Gonzalez-Suarez I, Schlage W, Hoeng J, Peitsch M.

Interdiscip Toxicol. 2014 Jun;7(2):73-84. doi: 10.2478/intox-2014-0010. Epub 2014 Nov 15.


Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts.

Iskandar AR, Xiang Y, Frentzel S, Talikka M, Leroy P, Kuehn D, Guedj E, Martin F, Mathis C, Ivanov NV, Peitsch MC, Hoeng J.

Toxicol Sci. 2015 Sep;147(1):207-21. doi: 10.1093/toxsci/kfv122. Epub 2015 Jun 16.


Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains.

Cabanski M, Fields B, Boue S, Boukharov N, DeLeon H, Dror N, Geertz M, Guedj E, Iskandar A, Kogel U, Merg C, Peck MJ, Poussin C, Schlage WK, Talikka M, Ivanov NV, Hoeng J, Peitsch MC.

Inflamm Res. 2015 Jul;64(7):471-86. doi: 10.1007/s00011-015-0820-2. Epub 2015 May 12.


Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems.

Boué S, Talikka M, Westra JW, Hayes W, Di Fabio A, Park J, Schlage WK, Sewer A, Fields B, Ansari S, Martin F, Veljkovic E, Kenney R, Peitsch MC, Hoeng J.

Database (Oxford). 2015 Apr 17;2015:bav030. doi: 10.1093/database/bav030. Print 2015.


A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product.

Phillips B, Veljkovic E, Peck MJ, Buettner A, Elamin A, Guedj E, Vuillaume G, Ivanov NV, Martin F, Boué S, Schlage WK, Schneider T, Titz B, Talikka M, Vanscheeuwijck P, Hoeng J, Peitsch MC.

Food Chem Toxicol. 2015 Jun;80:328-45. doi: 10.1016/j.fct.2015.03.009. Epub 2015 Apr 2.


A prototypic modified risk tobacco product exhibits reduced effects on chemotaxis and transendothelial migration of monocytes compared with a reference cigarette.

van der Toorn M, Frentzel S, Goedertier D, Peitsch M, Hoeng J, De Leon H.

Food Chem Toxicol. 2015 Jun;80:277-86. doi: 10.1016/j.fct.2015.03.026. Epub 2015 Mar 31.


Systems Toxicology: The Future of Risk Assessment.

Sauer JM, Hartung T, Leist M, Knudsen TB, Hoeng J, Hayes AW.

Int J Toxicol. 2015 Jul-Aug;34(4):346-8. doi: 10.1177/1091581815576551. Epub 2015 Mar 23.


A systems biology approach reveals the dose- and time-dependent effect of primary human airway epithelium tissue culture after exposure to cigarette smoke in vitro.

Mathis C, Gebel S, Poussin C, Belcastro V, Sewer A, Weisensee D, Hengstermann A, Ansari S, Wagner S, Peitsch MC, Hoeng J.

Bioinform Biol Insights. 2015 Mar 9;9:19-35. doi: 10.4137/BBI.S19908. eCollection 2015.


Enhancement of COPD biological networks using a web-based collaboration interface.

sbv IMPROVER project team (in alphabetical order), Boue S, Fields B, Hoeng J, Park J, Peitsch MC, Schlage WK, Talikka M; Challenge Best Performers (in alphabetical order), Binenbaum I, Bondarenko V, Bulgakov OV, Cherkasova V, Diaz-Diaz N, Fedorova L, Guryanova S, Guzova J, Igorevna Koroleva G, Kozhemyakina E, Kumar R, Lavid N, Lu Q, Menon S, Ouliel Y, Peterson SC, Prokhorov A, Sanders E, Schrier S, Schwaitzer Neta G, Shvydchenko I, Tallam A, Villa-Fombuena G, Wu J, Yudkevich I, Zelikman M.

F1000Res. 2015 Jan 29;4:32. doi: 10.12688/f1000research.5984.1. eCollection 2015.


Impact assessment of repeated exposure of organotypic 3D bronchial and nasal tissue culture models to whole cigarette smoke.

Kuehn D, Majeed S, Guedj E, Dulize R, Baumer K, Iskandar A, Boue S, Martin F, Kostadinova R, Mathis C, Ivanov NV, Frentzel S, Hoeng J, Peitsch MC.

J Vis Exp. 2015 Feb 12;(96). doi: 10.3791/52325.


Where are we at regarding species translation? A review of the sbv IMPROVER challenge.

Hoeng J, Peitsch MC, Meyer P, Jurisica I.

Bioinformatics. 2015 Feb 15;31(4):451-2. doi: 10.1093/bioinformatics/btv065. Epub 2015 Jan 31. No abstract available.

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