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Results: 1 to 20 of 55


Construction of biological networks from unstructured information based on a semi-automated curation workflow.

Szostak J, Ansari S, Madan S, Fluck J, Talikka M, Iskandar A, De Leon H, Hofmann-Apitius M, Peitsch MC, Hoeng J.

Database (Oxford). 2015 Jun 17;2015. pii: bav057. doi: 10.1093/database/bav057.


Systems biology reveals cigarette smoke-induced concentration-dependent direct and indirect mechanisms that promote monocyte-endothelial cell adhesion.

Poussin C, Laurent A, Peitsch MC, Hoeng J, De Leon H.

Toxicol Sci. 2015 Jul 2. pii: kfv137. [Epub ahead of print]


Systems Biology Research into Cardiovascular Disease: Contributions of Lipidomics-based Approaches to Biomarker Discovery.

De Leon H, Boue S, Szostak J, Peitsch MC, Hoeng J.

Curr Drug Discov Technol. 2015 Jul 2. [Epub ahead of print]


Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model.

Luettich K, Xiang Y, Iskandar A, Sewer A, Martin F, Talikka M, Vanscheeuwijck P, Berges A, Veljkovic E, Gonzalez-Suarez I, Schlage W, Hoeng J, Peitsch M.

Interdiscip Toxicol. 2014 Jun;7(2):73-84. doi: 10.2478/intox-2014-0010. Epub 2014 Nov 15.


Impact assessment of cigarette smoke exposure on organotypic bronchial epithelial tissue cultures: a comparison of mono-culture and co-culture model containing fibroblasts.

Iskandar AR, Xiang Y, Frentzel S, Talikka M, Leroy P, Kuehn D, Guedj E, Martin F, Mathis C, Ivanov N, Peitsch MC, Hoeng J.

Toxicol Sci. 2015 Jun 16. pii: kfv122. [Epub ahead of print]


Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains.

Cabanski M, Fields B, Boue S, Boukharov N, DeLeon H, Dror N, Geertz M, Guedj E, Iskandar A, Kogel U, Merg C, Peck MJ, Poussin C, Schlage WK, Talikka M, Ivanov NV, Hoeng J, Peitsch MC.

Inflamm Res. 2015 Jul;64(7):471-86. doi: 10.1007/s00011-015-0820-2. Epub 2015 May 12.


Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems.

Boué S, Talikka M, Westra JW, Hayes W, Di Fabio A, Park J, Schlage WK, Sewer A, Fields B, Ansari S, Martin F, Veljkovic E, Kenney R, Peitsch MC, Hoeng J.

Database (Oxford). 2015 Apr 17;2015:bav030. doi: 10.1093/database/bav030. Print 2015.


A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product.

Phillips B, Veljkovic E, Peck MJ, Buettner A, Elamin A, Guedj E, Vuillaume G, Ivanov NV, Martin F, Boué S, Schlage WK, Schneider T, Titz B, Talikka M, Vanscheeuwijck P, Hoeng J, Peitsch MC.

Food Chem Toxicol. 2015 Jun;80:328-45. doi: 10.1016/j.fct.2015.03.009. Epub 2015 Apr 2.


A prototypic modified risk tobacco product exhibits reduced effects on chemotaxis and transendothelial migration of monocytes compared with a reference cigarette.

van der Toorn M, Frentzel S, Goedertier D, Peitsch M, Hoeng J, De Leon H.

Food Chem Toxicol. 2015 Jun;80:277-86. doi: 10.1016/j.fct.2015.03.026. Epub 2015 Mar 31.


Systems Toxicology: The Future of Risk Assessment.

Sauer JM, Hartung T, Leist M, Knudsen TB, Hoeng J, Hayes AW.

Int J Toxicol. 2015 Mar 23. pii: 1091581815576551. [Epub ahead of print]


A systems biology approach reveals the dose- and time-dependent effect of primary human airway epithelium tissue culture after exposure to cigarette smoke in vitro.

Mathis C, Gebel S, Poussin C, Belcastro V, Sewer A, Weisensee D, Hengstermann A, Ansari S, Wagner S, Peitsch MC, Hoeng J.

Bioinform Biol Insights. 2015 Mar 9;9:19-35. doi: 10.4137/BBI.S19908. eCollection 2015.


Enhancement of COPD biological networks using a web-based collaboration interface.

sbv IMPROVER project team (in alphabetical order), Boue S, Fields B, Hoeng J, Park J, Peitsch MC, Schlage WK, Talikka M; Challenge Best Performers (in alphabetical order), Binenbaum I, Bondarenko V, Bulgakov OV, Cherkasova V, Diaz-Diaz N, Fedorova L, Guryanova S, Guzova J, Igorevna Koroleva G, Kozhemyakina E, Kumar R, Lavid N, Lu Q, Menon S, Ouliel Y, Peterson SC, Prokhorov A, Sanders E, Schrier S, Schwaitzer Neta G, Shvydchenko I, Tallam A, Villa-Fombuena G, Wu J, Yudkevich I, Zelikman M.

F1000Res. 2015 Jan 29;4:32. doi: 10.12688/f1000research.5984.1. eCollection 2015.


Impact assessment of repeated exposure of organotypic 3D bronchial and nasal tissue culture models to whole cigarette smoke.

Kuehn D, Majeed S, Guedj E, Dulize R, Baumer K, Iskandar A, Boue S, Martin F, Kostadinova R, Mathis C, Ivanov NV, Frentzel S, Hoeng J, Peitsch MC.

J Vis Exp. 2015 Feb 12;(96). doi: 10.3791/52325.


Where are we at regarding species translation? A review of the sbv IMPROVER challenge.

Hoeng J, Peitsch MC, Meyer P, Jurisica I.

Bioinformatics. 2015 Feb 15;31(4):451-2. doi: 10.1093/bioinformatics/btv065. Epub 2015 Jan 31. No abstract available.


Reputation-based collaborative network biology.

sbv IMPROVER Project Team, Binder J, Boue S, Di Fabio A, Fields RB, Hayes W, Hoeng J, Park JS, Peitsch MC.

Pac Symp Biocomput. 2015:270-81.


Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke.

Majeed S, Frentzel S, Wagner S, Kuehn D, Leroy P, Guy PA, Knorr A, Hoeng J, Peitsch MC.

Chem Cent J. 2014 Nov 12;8(1):62. doi: 10.1186/s13065-014-0062-3. eCollection 2014.


Proteomics for systems toxicology.

Titz B, Elamin A, Martin F, Schneider T, Dijon S, Ivanov NV, Hoeng J, Peitsch MC.

Comput Struct Biotechnol J. 2014 Aug 27;11(18):73-90. doi: 10.1016/j.csbj.2014.08.004. eCollection 2014 Aug. Review.


The response of human nasal and bronchial organotypic tissue cultures to repeated whole cigarette smoke exposure.

Talikka M, Kostadinova R, Xiang Y, Mathis C, Sewer A, Majeed S, Kuehn D, Frentzel S, Merg C, Geertz M, Martin F, Ivanov NV, Peitsch MC, Hoeng J.

Int J Toxicol. 2014 Nov-Dec;33(6):506-17. doi: 10.1177/1091581814551647. Epub 2014 Oct 8.


A crowd-sourcing approach for the construction of species-specific cell signaling networks.

Bilal E, Sakellaropoulos T, Melas IN, Messinis DE, Belcastro V, Rhrissorrakrai K, Meyer P, Norel R, Iskandar A, Blaese E, Rice JJ, Peitsch MC, Hoeng J, Stolovitzky G, Alexopoulos LG, Poussin C; Challenge Participants.

Bioinformatics. 2015 Feb 15;31(4):484-91. doi: 10.1093/bioinformatics/btu659. Epub 2014 Oct 7.


Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge.

Rhrissorrakrai K, Belcastro V, Bilal E, Norel R, Poussin C, Mathis C, Dulize RH, Ivanov NV, Alexopoulos L, Rice JJ, Peitsch MC, Stolovitzky G, Meyer P, Hoeng J.

Bioinformatics. 2015 Feb 15;31(4):471-83. doi: 10.1093/bioinformatics/btu611. Epub 2014 Sep 17.

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