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Results: 1 to 20 of 32

1.

Proinflammatory cytokines modulate the chemokine CCL2 (MCP-1) in human annulus cells in vitro: CCL2 expression and production.

Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Cox M, Hanley EN Jr.

Exp Mol Pathol. 2014 Dec 16. pii: S0014-4800(14)00199-3. doi: 10.1016/j.yexmp.2014.12.002. [Epub ahead of print]

PMID:
25527176
[PubMed - as supplied by publisher]
2.

Cortistatin is endogenous to the human intervertebral disc and exerts in vitro mitogenic effects on annulus cells and a downregulatory effect on TNF-α expression.

Gruber HE, Hoelscher GL, Bethea SF, Menscher EA, Ingram JA, Templin MA, Hanley EN Jr.

Spine J. 2014 Dec 1;14(12):2995-3001. doi: 10.1016/j.spinee.2014.06.002. Epub 2014 Jun 7.

PMID:
24912122
[PubMed - in process]
3.

A novel catechol-O-methyltransferase variant associated with human disc degeneration.

Gruber HE, Sha W, Brouwer CR, Steuerwald N, Hoelscher GL, Hanley EN Jr.

Int J Med Sci. 2014 May 15;11(7):748-53. doi: 10.7150/ijms.8770. eCollection 2014.

PMID:
24904231
[PubMed - in process]
Free PMC Article
4.

Growth and differentiation factor-5 (GDF-5) in the human intervertebral annulus cells and its modulation by IL-1ß and TNF-α in vitro.

Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Hanley EN Jr.

Exp Mol Pathol. 2014 Apr;96(2):225-9. doi: 10.1016/j.yexmp.2014.02.005. Epub 2014 Feb 25.

PMID:
24582800
[PubMed - indexed for MEDLINE]
5.

Production and expression of RANTES (CCL5) by human disc cells and modulation by IL-1-β and TNF-α in 3D culture.

Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Norton HJ, Hanley EN Jr.

Exp Mol Pathol. 2014 Apr;96(2):133-8. doi: 10.1016/j.yexmp.2014.01.002. Epub 2014 Jan 24.

PMID:
24468005
[PubMed - indexed for MEDLINE]
6.

Human annulus cells regulate PAPP-A and IGFBP-4 expression, and thereby insulin-like growth factor bioavailability, in response to proinflammatory cytokine exposure in vitro.

Gruber HE, Hoelscher GL, Ingram JA, Morton DS, Hanley EN Jr.

Connect Tissue Res. 2013;54(6):432-8. doi: 10.3109/03008207.2013.848200.

PMID:
24060054
[PubMed - indexed for MEDLINE]
7.

Increased IL-17 expression in degenerated human discs and increased production in cultured annulus cells exposed to IL-1ß and TNF-α.

Gruber HE, Hoelscher GL, Ingram JA, Norton HJ, Hanley EN Jr.

Biotech Histochem. 2013 Aug;88(6):302-10. doi: 10.3109/10520295.2013.783235. Epub 2013 Apr 30.

PMID:
23627571
[PubMed - indexed for MEDLINE]
8.

Genomewide molecular and biologic characterization of biomembrane formation adjacent to a methacrylate spacer in the rat femoral segmental defect model.

Gruber HE, Gettys FK, Montijo HE, Starman JS, Bayoumi E, Nelson KJ, Hoelscher GL, Ramp WK, Zinchenko N, Ingram JA, Bosse MJ, Kellam JF.

J Orthop Trauma. 2013 May;27(5):290-7. doi: 10.1097/BOT.0b013e3182691288.

PMID:
23609788
[PubMed - indexed for MEDLINE]
9.

Cell-based tissue engineering augments tendon-to-bone healing in a rat supraspinatus model.

Loeffler BJ, Scannell BP, Peindl RD, Connor P, Davis DE, Hoelscher GL, Norton HJ, Hanley EN Jr, Gruber HE.

J Orthop Res. 2013 Mar;31(3):407-12. doi: 10.1002/jor.22234. Epub 2012 Oct 15.

PMID:
23070709
[PubMed - indexed for MEDLINE]
10.

Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus.

Gruber HE, Hoelscher GL, Ingram JA, Hanley EN Jr.

Mol Pain. 2012 Sep 10;8:63. doi: 10.1186/1744-8069-8-63.

PMID:
22963171
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Interleukin 1-beta upregulates brain-derived neurotrophic factor, neurotrophin 3 and neuropilin 2 gene expression and NGF production in annulus cells.

Gruber HE, Hoelscher GL, Bethea S, Hanley EN Jr.

Biotech Histochem. 2012 Nov;87(8):506-11. doi: 10.3109/10520295.2012.703692. Epub 2012 Aug 2.

PMID:
22853041
[PubMed - indexed for MEDLINE]
12.

Deleterious effects of discography radiocontrast solution on human annulus cell in vitro: changes in cell viability, proliferation, and apoptosis in exposed cells.

Gruber HE, Rhyne AL 3rd, Hansen KJ, Phillips RC, Hoelscher GL, Ingram JA, Norton HJ, Hanley EN Jr.

Spine J. 2012 Apr;12(4):329-35. doi: 10.1016/j.spinee.2012.02.003. Epub 2012 Mar 16.

PMID:
22424848
[PubMed - indexed for MEDLINE]
13.

Human adipose-derived mesenchymal stem cells: serial passaging, doubling time and cell senescence.

Gruber HE, Somayaji S, Riley F, Hoelscher GL, Norton HJ, Ingram J, Hanley EN Jr.

Biotech Histochem. 2012 May;87(4):303-11. doi: 10.3109/10520295.2011.649785. Epub 2012 Jan 17.

PMID:
22250760
[PubMed - indexed for MEDLINE]
14.

Osteogenic and chondrogenic potential of biomembrane cells from the PMMA-segmental defect rat model.

Gruber HE, Riley FE, Hoelscher GL, Bayoumi EM, Ingram JA, Ramp WK, Bosse MJ, Kellam JF.

J Orthop Res. 2012 Aug;30(8):1198-212. doi: 10.1002/jor.22047. Epub 2012 Jan 13.

PMID:
22246998
[PubMed - indexed for MEDLINE]
15.

Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro.

Gruber HE, Hoelscher GL, Ingram JA, Hanley EN Jr.

Exp Mol Pathol. 2012 Feb;92(1):59-63. doi: 10.1016/j.yexmp.2011.09.008. Epub 2011 Sep 14.

PMID:
21945733
[PubMed - indexed for MEDLINE]
16.

Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand.

Gruber HE, Ingram JA, Hoelscher GL, Zinchenko N, Norton HJ, Hanley EN Jr.

Arthritis Res Ther. 2011 Aug 31;13(4):R140. doi: 10.1186/ar3454.

PMID:
21880134
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Mitochondrial gene expression in the human annulus: in vivo data from annulus cells and selectively harvested senescent annulus cells.

Gruber HE, Watts JA, Hoelscher GL, Bethea SF, Ingram JA, Zinchenko NS, Hanley EN Jr.

Spine J. 2011 Aug;11(8):782-91. doi: 10.1016/j.spinee.2011.06.012. Epub 2011 Jul 23.

PMID:
21784712
[PubMed - indexed for MEDLINE]
18.

Variations in aggrecan localization and gene expression patterns characterize increasing stages of human intervertebral disk degeneration.

Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Zinchenko N, Hanley EN Jr.

Exp Mol Pathol. 2011 Oct;91(2):534-9. doi: 10.1016/j.yexmp.2011.06.001. Epub 2011 Jun 12.

PMID:
21689646
[PubMed - indexed for MEDLINE]
19.

Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs.

Gruber HE, Hoelscher GL, Hanley EN Jr.

Spine J. 2010 Aug;10(8):721-7. doi: 10.1016/j.spinee.2010.05.014.

PMID:
20650410
[PubMed - indexed for MEDLINE]
20.

Human adipose-derived mesenchymal stem cells: direction to a phenotype sharing similarities with the disc, gene expression profiling, and coculture with human annulus cells.

Gruber HE, Deepe R, Hoelscher GL, Ingram JA, Norton HJ, Scannell B, Loeffler BJ, Zinchenko N, Hanley EN, Tapp H.

Tissue Eng Part A. 2010 Sep;16(9):2843-60. doi: 10.1089/ten.TEA.2009.0709.

PMID:
20408770
[PubMed - indexed for MEDLINE]

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