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HIV-1 shedding from the female genital tract is associated with increased Th1 cytokines/chemokines that maintain tissue homeostasis and proportions of CD8+FOXP3+ T cells.

Bull ME, Legard J, Tapia K, Sorensen B, Cohn SE, Garcia R, Holte SE, Coombs RW, Hitti JE.

J Acquir Immune Defic Syndr. 2014 Dec 1;67(4):357-64. doi: 10.1097/QAI.0000000000000336.


A hemolytic pigment of Group B Streptococcus allows bacterial penetration of human placenta.

Whidbey C, Harrell MI, Burnside K, Ngo L, Becraft AK, Iyer LM, Aravind L, Hitti J, Waldorf KM, Rajagopal L.

J Exp Med. 2013 Jun 3;210(6):1265-81. doi: 10.1084/jem.20122753. Epub 2013 May 27.


Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission.

Vardhanabhuti S, Acosta EP, Ribaudo HJ, Severe P, Lalloo U, Kumarasamy N, Taulo F, Kabanda J, Oneko O, Ive P, Sambarey P, Chan ES, Hitti J, Hong F, McMahon D, Haas DW; A5207 ACTG Study Team.

J Infect Dis. 2013 Aug 15;208(4):662-71. doi: 10.1093/infdis/jit223. Epub 2013 May 17.


Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya.

Coleman JS, Mwachari C, Balkus J, Sanguli L, Muliro A, Agnew K, Coombs RW, Cohen CR, Hitti J.

J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):245-8. doi: 10.1097/QAI.0b013e31828decf8.


Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time.

Bull ME, Heath LM, McKernan-Mullin JL, Kraft KM, Acevedo L, Hitti JE, Cohn SE, Tapia KA, Holte SE, Dragavon JA, Coombs RW, Mullins JI, Frenkel LM.

J Infect Dis. 2013 Apr 15;207(8):1206-15. doi: 10.1093/infdis/jit016. Epub 2013 Jan 11.


Greater suppression of nevirapine resistance with 21- vs 7-day antiretroviral regimens after intrapartum single-dose nevirapine for prevention of mother-to-child transmission of HIV.

McMahon DK, Zheng L, Hitti J, Chan ES, Halvas EK, Hong F, Kabanda J, Taulo F, Kumarasamy N, Bonhomme J, Wallis CL, Klingman KL, Hughes MD, Mellors JW.

Clin Infect Dis. 2013 Apr;56(7):1044-51. doi: 10.1093/cid/cis1219. Epub 2013 Jan 8.


Interaction between lactobacilli, bacterial vaginosis-associated bacteria, and HIV Type 1 RNA and DNA Genital shedding in U.S. and Kenyan women.

Mitchell C, Balkus JE, Fredricks D, Liu C, McKernan-Mullin J, Frenkel LM, Mwachari C, Luque A, Cohn SE, Cohen CR, Coombs R, Hitti J.

AIDS Res Hum Retroviruses. 2013 Jan;29(1):13-9. doi: 10.1089/AID.2012.0187. Epub 2012 Nov 5.


Associations between genital tract infections, genital tract inflammation, and cervical cytobrush HIV-1 DNA in US versus Kenyan women.

Mitchell C, Balkus JE, McKernan-Mullin J, Cohn SE, Luque AE, Mwachari C, Cohen CR, Coombs R, Frenkel LM, Hitti J.

J Acquir Immune Defic Syndr. 2013 Feb 1;62(2):143-8. doi: 10.1097/QAI.0b013e318274577d.


Detection of hydrogen peroxide-producing Lactobacillus species in the vagina: a comparison of culture and quantitative PCR among HIV-1 seropositive women.

Balkus JE, Mitchell C, Agnew K, Liu C, Fiedler T, Cohn SE, Luque A, Coombs R, Fredricks DN, Hitti J.

BMC Infect Dis. 2012 Aug 13;12:188. doi: 10.1186/1471-2334-12-188.


Examining the challenges and solutions to the implementation of trials in resource-limited settings: Limited Resource Trials.

Blanchard-Horan C, Stocker V, Moran L, Ferguson EO, Klingman KL, McMahon D, Hitti J.

Appl Clin Trials. 2012 Jan 1;21(1):34-42. No abstract available.


Infant outcomes after maternal antiretroviral exposure in resource-limited settings.

Nielsen-Saines K, Komarow L, Cu-Uvin S, Jourdain G, Klingman KL, Shapiro DE, Mofenson L, Moran L, Campbell TB, Hitti J, Fiscus S, Currier J; ACTG 5190/PACTG 1054 Study Team.

Pediatrics. 2012 Jun;129(6):e1525-32. doi: 10.1542/peds.2011-2340. Epub 2012 May 14.


Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and postpartum: a randomized trial.

Drake AL, Roxby AC, Ongecha-Owuor F, Kiarie J, John-Stewart G, Wald A, Richardson BA, Hitti J, Overbaugh J, Emery S, Farquhar C.

J Infect Dis. 2012 Feb 1;205(3):366-75. doi: 10.1093/infdis/jir766. Epub 2011 Dec 6.


Selection of HIV resistance associated with antiretroviral therapy initiated due to pregnancy and suspended postpartum.

Ellis GM, Huang S, Hitti J, Frenkel LM; P1022 Study Team.

J Acquir Immune Defic Syndr. 2011 Nov 1;58(3):241-7. doi: 10.1097/QAI.0b013e31822b4edc.


Genital HSV detection among HIV-1-infected pregnant women in labor.

Patterson J, Hitti J, Selke S, Huang ML, Watts DH, Brown Z, Corey L, Wald A.

Infect Dis Obstet Gynecol. 2011;2011:157680. doi: 10.1155/2011/157680. Epub 2011 Mar 27.


Estimating volume of cervicovaginal secretions in cervicovaginal lavage fluid collected for measurement of genital HIV-1 RNA levels in women.

Mitchell C, Paul K, Agnew K, Gaussman R, Coombs RW, Hitti J.

J Clin Microbiol. 2011 Feb;49(2):735-6. doi: 10.1128/JCM.00991-10. Epub 2010 Nov 24.


Cervicovaginal shedding of HIV type 1 is related to genital tract inflammation independent of changes in vaginal microbiota.

Mitchell C, Hitti J, Paul K, Agnew K, Cohn SE, Luque AE, Coombs R.

AIDS Res Hum Retroviruses. 2011 Jan;27(1):35-9. doi: 10.1089/aid.2010.0129. Epub 2010 Oct 7.


Prevalence of human papillomavirus genotypes in HIV-1-infected women in Seattle, USA and Nairobi, Kenya: results from the Women's HIV Interdisciplinary Network (WHIN).

Luque AE, Hitti J, Mwachari C, Lane C, Messing S, Cohn SE, Adler D, Rose R, Coombs R.

Int J Infect Dis. 2010 Sep;14(9):e810-4. doi: 10.1016/j.ijid.2010.03.016. Epub 2010 Jul 22.


Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid.

Hitti J, Lapidus JA, Lu X, Reddy AP, Jacob T, Dasari S, Eschenbach DA, Gravett MG, Nagalla SR.

Am J Obstet Gynecol. 2010 Jul;203(1):32.e1-8. doi: 10.1016/j.ajog.2010.03.037. Epub 2010 May 15.


Inadequate prenatal care and risk of preterm delivery among adolescents: a retrospective study over 10 years.

Debiec KE, Paul KJ, Mitchell CM, Hitti JE.

Am J Obstet Gynecol. 2010 Aug;203(2):122.e1-6. doi: 10.1016/j.ajog.2010.03.001. Epub 2010 May 14.


Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington State.

Waller SA, Paul K, Peterson SE, Hitti JE.

Am J Obstet Gynecol. 2010 Mar;202(3):241.e1-6. doi: 10.1016/j.ajog.2010.01.023. Erratum in: Am J Obstet Gynecol. 2010 Aug;203(2):183.

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