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Results: 1 to 20 of 80


Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration.

Zhang A, Hitomi M, Bar-Shain N, Dalimov Z, Ellis L, Velpula KK, Fraizer GC, Gourdie RG, Lathia JD.

Oncotarget. 2015 May 10;6(13):11640-51.


Differential connexin function enhances self-renewal in glioblastoma.

Hitomi M, Deleyrolle LP, Mulkearns-Hubert EE, Jarrar A, Li M, Sinyuk M, Otvos B, Brunet S, Flavahan WA, Hubert CG, Goan W, Hale JS, Alvarado AG, Zhang A, Rohaus M, Oli M, Vedam-Mai V, Fortin JM, Futch HS, Griffith B, Wu Q, Xia CH, Gong X, Ahluwalia MS, Rich JN, Reynolds BA, Lathia JD.

Cell Rep. 2015 May 19;11(7):1031-42. doi: 10.1016/j.celrep.2015.04.021. Epub 2015 May 7.


Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple-Negative Breast Cancer.

Thiagarajan PS, Hitomi M, Hale JS, Alvarado AG, Otvos B, Sinyuk M, Stoltz K, Wiechert A, Mulkearns-Hubert E, Jarrar AM, Zheng Q, Thomas D, Egelhoff TT, Rich JN, Liu H, Lathia JD, Reizes O.

Stem Cells. 2015 Jul;33(7):2114-25. doi: 10.1002/stem.2021. Epub 2015 May 15.


The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells.

Kim SH, Kim EJ, Hitomi M, Oh SY, Jin X, Jeon HM, Beck S, Jin X, Kim JK, Park CG, Chang SY, Yin J, Kim T, Jeon YJ, Song J, Lim YC, Lathia JD, Nakano I, Kim H.

Cell Death Differ. 2015 Feb 27. doi: 10.1038/cdd.2015.7. [Epub ahead of print]


Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron.

Visconte V, Avishai N, Mahfouz R, Tabarroki A, Cowen J, Sharghi-Moshtaghin R, Hitomi M, Rogers HJ, Hasrouni E, Phillips J, Sekeres MA, Heuer AH, Saunthararajah Y, Barnard J, Tiu RV.

Leukemia. 2015 Jan;29(1):188-95. doi: 10.1038/leu.2014.170. Epub 2014 May 23.


Cancer stem cell-specific scavenger receptor 36 drives glioblastoma progression.

Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, Silverstein RL, Gladson CL, DiDonato JA, Brown JM, McIntyre T, Hazen SL, Horbinski C, Rich JN, Lathia JD.

Stem Cells. 2014 Jul;32(7):1746-58. doi: 10.1002/stem.1716.


High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor.

Lathia JD, Li M, Sinyuk M, Alvarado AG, Flavahan WA, Stoltz K, Rosager AM, Hale J, Hitomi M, Gallagher J, Wu Q, Martin J, Vidal JG, Nakano I, Dahlrot RH, Hansen S, McLendon RE, Sloan AE, Bao S, Hjelmeland AB, Carson CT, Naik UP, Kristensen B, Rich JN.

Cell Rep. 2014 Jan 16;6(1):117-29. doi: 10.1016/j.celrep.2013.11.043. Epub 2013 Dec 27.


Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A.

Lotti F, Jarrar AM, Pai RK, Hitomi M, Lathia J, Mace A, Gantt GA Jr, Sukhdeo K, DeVecchio J, Vasanji A, Leahy P, Hjelmeland AB, Kalady MF, Rich JN.

J Exp Med. 2013 Dec 16;210(13):2851-72. doi: 10.1084/jem.20131195. Epub 2013 Dec 9.


Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake.

Flavahan WA, Wu Q, Hitomi M, Rahim N, Kim Y, Sloan AE, Weil RJ, Nakano I, Sarkaria JN, Stringer BW, Day BW, Li M, Lathia JD, Rich JN, Hjelmeland AB.

Nat Neurosci. 2013 Oct;16(10):1373-82. doi: 10.1038/nn.3510. Epub 2013 Sep 1.


Aptamer identification of brain tumor-initiating cells.

Kim Y, Wu Q, Hamerlik P, Hitomi M, Sloan AE, Barnett GH, Weil RJ, Leahy P, Hjelmeland AB, Rich JN.

Cancer Res. 2013 Aug 1;73(15):4923-36. doi: 10.1158/0008-5472.CAN-12-4556. Epub 2013 Jun 24.


Myo1c facilitates G-actin transport to the leading edge of migrating endothelial cells.

Fan Y, Eswarappa SM, Hitomi M, Fox PL.

J Cell Biol. 2012 Jul 9;198(1):47-55. doi: 10.1083/jcb.201111088.


Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity.

Kim Y, Kim E, Wu Q, Guryanova O, Hitomi M, Lathia JD, Serwanski D, Sloan AE, Weil RJ, Lee J, Nishiyama A, Bao S, Hjelmeland AB, Rich JN.

Genes Dev. 2012 Jun 1;26(11):1247-62. doi: 10.1101/gad.193565.112.


Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions.

Lathia JD, Hitomi M, Gallagher J, Gadani SP, Adkins J, Vasanji A, Liu L, Eyler CE, Heddleston JM, Wu Q, Minhas S, Soeda A, Hoeppner DJ, Ravin R, McKay RD, McLendon RE, Corbeil D, Chenn A, Hjelmeland AB, Park DM, Rich JN.

Cell Death Dis. 2011 Sep 1;2:e200. doi: 10.1038/cddis.2011.80.


Glioma stem cell maintenance: the role of the microenvironment.

Heddleston JM, Hitomi M, Venere M, Flavahan WA, Yang K, Kim Y, Minhas S, Rich JN, Hjelmeland AB.

Curr Pharm Des. 2011;17(23):2386-401. Review.


The checkpoint kinase ATM protects against stress-induced elevation of cyclin D1 and potential cell death in neurons.

Hitomi M, Stacey DW.

Cytometry A. 2010 Jun;77(6):524-33. doi: 10.1002/cyto.a.20885.


Development of high-speed polarizing imaging system for operation in high pulsed magnetic field.

Katakura I, Tokunaga M, Matsuo A, Kawaguchi K, Kindo K, Hitomi M, Akahoshi D, Kuwahara H.

Rev Sci Instrum. 2010 Apr;81(4):043701. doi: 10.1063/1.3359954.


Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression.

Hitomi M, Yang K, Stacey AW, Stacey DW.

Mol Cell Biol. 2008 Sep;28(17):5478-93. doi: 10.1128/MCB.02047-07. Epub 2008 Jul 7.


Cell cycle studies based upon quantitative image analysis.

Stacey DW, Hitomi M.

Cytometry A. 2008 Apr;73(4):270-8. doi: 10.1002/cyto.a.20511. Review.


p27Kip1 and cyclin dependent kinase 2 regulate passage through the restriction point.

Hitomi M, Yang K, Guo Y, Fretthold J, Harwalkar J, Stacey DW.

Cell Cycle. 2006 Oct;5(19):2281-9. Epub 2006 Oct 1.

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