Format

Send to:

Choose Destination
See comment in PubMed Commons below
BMC Med Genomics. 2012 Nov 28;5:56. doi: 10.1186/1755-8794-5-56.

Autworks: a cross-disease network biology application for Autism and related disorders.

Author information

  • 1The Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

Abstract

BACKGROUND:

The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results.

DESCRIPTION:

We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis.

CONCLUSIONS:

Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders.

AVAILABILITY:

http://autworks.hms.harvard.edu/

PMID:
23190929
[PubMed - indexed for MEDLINE]
PMCID:
PMC3533944
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk