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Results: 1 to 20 of 217


γ-secretase directly sheds the survival receptor BCMA from plasma cells.

Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E.

Nat Commun. 2015 Jun 11;6:7333. doi: 10.1038/ncomms8333.


Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors.

Taddeo A, Khodadadi L, Voigt C, Mumtaz IM, Cheng Q, Moser K, Alexander T, Manz RA, Radbruch A, Hiepe F, Hoyer BF.

Arthritis Res Ther. 2015 Mar 2;17(1):39. [Epub ahead of print]


[Pathogenesis of systemic lupus erythematosus].

Alexander T, Radbruch A, Hiepe F.

Z Rheumatol. 2015 Apr;74(3):183-90. doi: 10.1007/s00393-014-1456-2. German.


The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus.

Alexander T, Sarfert R, Klotsche J, Kühl AA, Rubbert-Roth A, Lorenz HM, Rech J, Hoyer BF, Cheng Q, Waka A, Taddeo A, Wiesener M, Schett G, Burmester GR, Radbruch A, Hiepe F, Voll RE.

Ann Rheum Dis. 2015 Jul;74(7):1474-8. doi: 10.1136/annrheumdis-2014-206016. Epub 2015 Feb 20.


[Plasma cells].

Hiepe F, Alexander T, Voll RE.

Z Rheumatol. 2015 Feb;74(1):20-5. doi: 10.1007/s00393-014-1438-4. German.


Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE.

Humrich JY, von Spee-Mayer C, Siegert E, Alexander T, Hiepe F, Radbruch A, Burmester GR, Riemekasten G.

Ann Rheum Dis. 2015 Apr;74(4):791-2. doi: 10.1136/annrheumdis-2014-206506. Epub 2015 Jan 21. No abstract available.


The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.

Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E.

J Immunol. 2015 Jan 15;194(2):542-52. doi: 10.4049/jimmunol.1402070. Epub 2014 Dec 10.


SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking.

Alexander T, Bondanza A, Muraro PA, Greco R, Saccardi R, Daikeler T, Kazmi M, Hawkey C, Simoes BP, Leblanc K, Fibbe WE, Moore J, Snarski E, Martin T, Hiepe F, Velardi A, Toubert A, Snowden JA, Farge D.

Bone Marrow Transplant. 2015 Feb;50(2):173-80. doi: 10.1038/bmt.2014.251. Epub 2014 Nov 10.


Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation.

Sieber J, Daridon C, Fleischer SJ, Fleischer V, Hiepe F, Alexander T, Heine G, Burmester GR, Fillatreau S, Dörner T.

Arthritis Res Ther. 2014 Nov 11;16(6):477. doi: 10.1186/s13075-014-0477-1.


[Rheumatoid factor or antinuclear antibodies as incidental finding].

Biesen R, Burmester GR, Hiepe F.

Internist (Berl). 2014 Oct;55(10):1157-64. doi: 10.1007/s00108-014-3588-5. German.


Selection and depletion of plasma cells based on the specificity of the secreted antibody.

Taddeo A, Gerl V, Hoyer BF, Chang HD, Kohler S, Schaffert H, Thiel A, Radbruch A, Hiepe F.

Eur J Immunol. 2015 Jan;45(1):317-9. doi: 10.1002/eji.201444993. Epub 2014 Nov 2. No abstract available.


Where is lupus hidden?

Hiepe F.

Presse Med. 2014 Jun;43(6 Pt 2):e143-50. doi: 10.1016/j.lpm.2014.04.005. Epub 2014 Jun 4. Review.


The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity.

Medgyesi D, Hobeika E, Biesen R, Kollert F, Taddeo A, Voll RE, Hiepe F, Reth M.

J Exp Med. 2014 Mar 10;211(3):427-40. doi: 10.1084/jem.20131196. Epub 2014 Mar 3.


Cell-specific type I IFN signatures in autoimmunity and viral infection: what makes the difference?

Kyogoku C, Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Häupl T, Hiepe F, Alexander T, Radbruch A, Grützkau A.

PLoS One. 2013 Dec 31;8(12):e83776. doi: 10.1371/journal.pone.0083776. eCollection 2013.


Autoantibodies from long-lived 'memory' plasma cells of NZB/W mice drive immune complex nephritis.

Cheng Q, Mumtaz IM, Khodadadi L, Radbruch A, Hoyer BF, Hiepe F.

Ann Rheum Dis. 2013 Dec;72(12):2011-7. doi: 10.1136/annrheumdis-2013-203455. Epub 2013 Oct 10.


Disturbed B cell subpopulations and increased plasma cells in myasthenia gravis patients.

Kohler S, Keil TO, Swierzy M, Hoffmann S, Schaffert H, Ismail M, Rückert JC, Alexander T, Hiepe F, Gross C, Thiel A, Meisel A.

J Neuroimmunol. 2013 Nov 15;264(1-2):114-9. doi: 10.1016/j.jneuroim.2013.09.006. Epub 2013 Sep 18.


[Statement on the use of mycophenolate mofetil for systemic lupus erythematosus].

Aringer M, Fischer-Betz R, Hiepe F; Kommission Pharmakotherapie der DGRh; Germany Society of Rheumatology.

Z Rheumatol. 2013 Aug;72(6):575-80. doi: 10.1007/s00393-013-1213-y. German.


Urinary CD4 T cells identify SLE patients with proliferative lupus nephritis and can be used to monitor treatment response.

Enghard P, Rieder C, Kopetschke K, Klocke JR, Undeutsch R, Biesen R, Dragun D, Gollasch M, Schneider U, Aupperle K, Humrich JY, Hiepe F, Backhaus M, Radbruch AH, Burmester GR, Riemekasten G.

Ann Rheum Dis. 2014 Jan;73(1):277-83. doi: 10.1136/annrheumdis-2012-202784. Epub 2013 Mar 8.


Development and resolution of secondary autoimmunity after autologous haematopoietic stem cell transplantation for systemic lupus erythematosus: competition of plasma cells for survival niches?

Alexander T, Schneider S, Hoyer B, Cheng Q, Thiel A, Ziemer S, Burmester GR, Arnold R, Radbruch A, Hiepe F.

Ann Rheum Dis. 2013 Jun;72(6):1102-4. doi: 10.1136/annrheumdis-2012-202729. Epub 2013 Jan 29. No abstract available.


Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus.

Alexander T, Sattler A, Templin L, Kohler S, Groß C, Meisel A, Sawitzki B, Burmester GR, Arnold R, Radbruch A, Thiel A, Hiepe F.

Ann Rheum Dis. 2013 Sep 1;72(9):1549-58. doi: 10.1136/annrheumdis-2012-202216. Epub 2012 Dec 21.

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