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Items: 1 to 20 of 228


Autoantibodies, complement and type I interferon as biomarkers for personalized medicine in SLE.

Biesen R, Rose T, Hoyer BF, Alexander T, Hiepe F.

Lupus. 2016 Jul;25(8):823-9. doi: 10.1177/0961203316640922.


[Immunomodulatory therapy of autoimmune diseases : Quo vadis?].

Hoyer BF, Hiepe F.

Ophthalmologe. 2016 May;113(5):373-9. doi: 10.1007/s00347-016-0263-3. German.


Myasthenia gravis: subgroup classifications.

Kohler S, Losen M, Alexander T, Hiepe F, Meisel A.

Lancet Neurol. 2016 Apr;15(4):356-7. doi: 10.1016/S1474-4422(16)00033-8. No abstract available.


Plasma cells as an innovative target in autoimmune disease with renal manifestations.

Hiepe F, Radbruch A.

Nat Rev Nephrol. 2016 Apr;12(4):232-40. doi: 10.1038/nrneph.2016.20. Epub 2016 Feb 29. Review.


Devastating humoral CIDP variant remitted by autologous stem cell transplantation.

Scheibe F, Alexander T, Prüss H, Wengert O, Harms L, Angstwurm K, Hiepe F, Arnold R, Meisel A.

Eur J Neurol. 2016 Mar;23(3):e12-4. doi: 10.1111/ene.12896. No abstract available.


Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood: A semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses.

Wilhelm TR, Taddeo A, Winter O, Schulz AR, Mälzer JN, Domingo C, Biesen R, Alexander T, Thiel A, Radbruch A, Hiepe F, Gerl V.

Clin Immunol. 2016 Feb;163:42-51. doi: 10.1016/j.clim.2015.12.001. Epub 2015 Dec 7.


Analyzing pathogenic (double-stranded (ds) DNA-specific) plasma cells via immunofluorescence microscopy.

Winter O, Musiol S, Schablowsky M, Cheng Q, Khodadadi L, Hiepe F.

Arthritis Res Ther. 2015 Oct 21;17:293. doi: 10.1186/s13075-015-0811-2.


Serum antibodies to human leucocyte antigen (HLA)-E, HLA-F and HLA-G in patients with systemic lupus erythematosus (SLE) during disease flares: Clinical relevance of HLA-F autoantibodies.

Jucaud V, Ravindranath MH, Terasaki PI, Morales-Buenrostro LE, Hiepe F, Rose T, Biesen R.

Clin Exp Immunol. 2016 Mar;183(3):326-40. doi: 10.1111/cei.12724. Epub 2015 Dec 16.


Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus.

von Spee-Mayer C, Siegert E, Abdirama D, Rose A, Klaus A, Alexander T, Enghard P, Sawitzki B, Hiepe F, Radbruch A, Burmester GR, Riemekasten G, Humrich JY.

Ann Rheum Dis. 2016 Jul;75(7):1407-15. doi: 10.1136/annrheumdis-2015-207776. Epub 2015 Aug 31.


Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice.

Khodadadi L, Cheng Q, Alexander T, Sercan-Alp Ö, Klotsche J, Radbruch A, Hiepe F, Hoyer BF, Taddeo A.

PLoS One. 2015 Aug 7;10(8):e0135081. doi: 10.1371/journal.pone.0135081. eCollection 2015.


Impact of switching from mycophenolate mofetil to enteric-coated mycophenolate sodium on gastrointestinal side effects in patients with autoimmune disease: a Phase III, open-label, single-arm, multicenter study.

Manger B, Hiepe F, Schneider M, Worm M, Wimmer P, Paulus EM, Schwarting A.

Clin Exp Gastroenterol. 2015 Jul 21;8:205-13. doi: 10.2147/CEG.S81922. eCollection 2015.


γ-Secretase directly sheds the survival receptor BCMA from plasma cells.

Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E.

Nat Commun. 2015 Jun 11;6:7333. doi: 10.1038/ncomms8333.


Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors.

Taddeo A, Khodadadi L, Voigt C, Mumtaz IM, Cheng Q, Moser K, Alexander T, Manz RA, Radbruch A, Hiepe F, Hoyer BF.

Arthritis Res Ther. 2015 Mar 2;17:39. doi: 10.1186/s13075-015-0551-3.


[Pathogenesis of systemic lupus erythematosus].

Alexander T, Radbruch A, Hiepe F.

Z Rheumatol. 2015 Apr;74(3):183-90. doi: 10.1007/s00393-014-1456-2. German.


The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus.

Alexander T, Sarfert R, Klotsche J, Kühl AA, Rubbert-Roth A, Lorenz HM, Rech J, Hoyer BF, Cheng Q, Waka A, Taddeo A, Wiesener M, Schett G, Burmester GR, Radbruch A, Hiepe F, Voll RE.

Ann Rheum Dis. 2015 Jul;74(7):1474-8. doi: 10.1136/annrheumdis-2014-206016. Epub 2015 Feb 20.


[Plasma cells].

Hiepe F, Alexander T, Voll RE.

Z Rheumatol. 2015 Feb;74(1):20-5. doi: 10.1007/s00393-014-1438-4. German.


Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE.

Humrich JY, von Spee-Mayer C, Siegert E, Alexander T, Hiepe F, Radbruch A, Burmester GR, Riemekasten G.

Ann Rheum Dis. 2015 Apr;74(4):791-2. doi: 10.1136/annrheumdis-2014-206506. Epub 2015 Jan 21. No abstract available.


The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.

Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E.

J Immunol. 2015 Jan 15;194(2):542-52. doi: 10.4049/jimmunol.1402070. Epub 2014 Dec 10.


SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking.

Alexander T, Bondanza A, Muraro PA, Greco R, Saccardi R, Daikeler T, Kazmi M, Hawkey C, Simoes BP, Leblanc K, Fibbe WE, Moore J, Snarski E, Martin T, Hiepe F, Velardi A, Toubert A, Snowden JA, Farge D.

Bone Marrow Transplant. 2015 Feb;50(2):173-80. doi: 10.1038/bmt.2014.251. Epub 2014 Nov 10. Review.


Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation.

Sieber J, Daridon C, Fleischer SJ, Fleischer V, Hiepe F, Alexander T, Heine G, Burmester GR, Fillatreau S, Dörner T.

Arthritis Res Ther. 2014 Nov 11;16(6):477. doi: 10.1186/s13075-014-0477-1.

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