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Results: 1 to 20 of 39

1.

Phase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer.

Hezel AF, Noel MS, Allen JN, Abrams TA, Yurgelun M, Faris JE, Goyal L, Clark JW, Blaszkowsky LS, Murphy JE, Zheng H, Khorana AA, Connolly GC, Hyrien O, Baran A, Herr M, Ng K, Sheehan S, Harris DJ, Regan E, Borger DR, Iafrate AJ, Fuchs C, Ryan DP, Zhu AX.

Br J Cancer. 2014 Jun 24. doi: 10.1038/bjc.2014.343. [Epub ahead of print]

PMID:
24960403
[PubMed - as supplied by publisher]
2.

Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.

Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H.

Cell Rep. 2014 May 22;7(4):1143-55. doi: 10.1016/j.celrep.2014.03.061. Epub 2014 May 1.

PMID:
24794439
[PubMed - in process]
Free Article
3.

Stereotactic body radiation therapy as a bridge to transplantation and for recurrent disease in the transplanted liver of a patient with hepatocellular carcinoma.

Mazloom A, Hezel AF, Katz AW.

Case Rep Oncol. 2014 Jan 10;7(1):18-22. doi: 10.1159/000357801. eCollection 2014 Jan.

PMID:
24575010
[PubMed]
Free PMC Article
4.

New and emerging treatment options for biliary tract cancer.

Noel MS, Hezel AF.

Onco Targets Ther. 2013 Oct 30;6:1545-52. doi: 10.2147/OTT.S32545. Review.

PMID:
24204165
[PubMed]
Free PMC Article
5.

Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma.

Goyal L, Supko JG, Berlin J, Blaszkowsky LS, Carpenter A, Heuman DM, Hilderbrand SL, Stuart KE, Cotler S, Senzer NN, Chan E, Berg CL, Clark JW, Hezel AF, Ryan DP, Zhu AX.

Cancer Chemother Pharmacol. 2013 Dec;72(6):1305-14.

PMID:
24121453
[PubMed - indexed for MEDLINE]
6.

Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma.

Connolly GC, Safadjou S, Kashyap R, Chen R, Orloff MS, Hezel AF.

BMC Gastroenterol. 2013 Jan 14;13:9. doi: 10.1186/1471-230X-13-9.

PMID:
23317091
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Unresectable locally advanced pancreatic cancer: treatment with neoadjuvant leucovorin, fluorouracil, irinotecan, and oxaliplatin and assessment of surgical resectability.

Mondo EL, Noel MS, Katz AW, Schoeniger LO, Hezel AF.

J Clin Oncol. 2013 Jan 20;31(3):e37-9. doi: 10.1200/JCO.2012.44.0339. Epub 2012 Dec 10. No abstract available.

PMID:
23233707
[PubMed - indexed for MEDLINE]
8.

Diabetes mellitus is associated with the presence of metastatic spread at disease presentation in hepatocellular carcinoma.

Connolly GC, Safadjou S, Chen R, Nduaguba A, Dunne R, Khorana AA, Hezel AF.

Cancer Invest. 2012 Dec;30(10):698-702. doi: 10.3109/07357907.2012.732162. Epub 2012 Oct 16.

PMID:
23072586
[PubMed - indexed for MEDLINE]
9.

TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression.

Hezel AF, Deshpande V, Zimmerman SM, Contino G, Alagesan B, O'Dell MR, Rivera LB, Harper J, Lonning S, Brekken RA, Bardeesy N.

Cancer Res. 2012 Sep 15;72(18):4840-5. doi: 10.1158/0008-5472.CAN-12-0634. Epub 2012 Jul 11.

PMID:
22787119
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Autophagy in intra-hepatic cholangiocarcinoma.

Huang JL, Hezel AF.

Autophagy. 2012 Jul 1;8(7):1148-9. doi: 10.4161/auto.20647. Epub 2012 Jul 1.

PMID:
22751196
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA.

Cell. 2012 Apr 27;149(3):656-70. doi: 10.1016/j.cell.2012.01.058.

PMID:
22541435
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Intraductal papillary mucinous adenocarcinoma of the pancreas: clinical outcomes, prognostic factors, and the role of adjuvant therapy.

Alexander BM, Fernandez-Del Castillo C, Ryan DP, Kachnic LA, Hezel AF, Niemierko A, Willett CG, Kozak KR, Blaszkowsky LS, Clark JW, Warshaw AL, Hong TS.

Gastrointest Cancer Res. 2011 Jul;4(4):116-21.

PMID:
22368734
[PubMed]
Free PMC Article
13.

Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma.

O'Dell MR, Huang JL, Whitney-Miller CL, Deshpande V, Rothberg P, Grose V, Rossi RM, Zhu AX, Land H, Bardeesy N, Hezel AF.

Cancer Res. 2012 Mar 15;72(6):1557-67. doi: 10.1158/0008-5472.CAN-11-3596. Epub 2012 Jan 20.

PMID:
22266220
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab.

Wadlow RC, Hezel AF, Abrams TA, Blaszkowsky LS, Fuchs CS, Kulke MH, Kwak EL, Meyerhardt JA, Ryan DP, Szymonifka J, Wolpin BM, Zhu AX, Clark JW.

Oncologist. 2012;17(1):14. doi: 10.1634/theoncologist.2011-0452. Epub 2011 Dec 30.

PMID:
22210091
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.

Borger DR, Tanabe KK, Fan KC, Lopez HU, Fantin VR, Straley KS, Schenkein DP, Hezel AF, Ancukiewicz M, Liebman HM, Kwak EL, Clark JW, Ryan DP, Deshpande V, Dias-Santagata D, Ellisen LW, Zhu AX, Iafrate AJ.

Oncologist. 2012;17(1):72-9. doi: 10.1634/theoncologist.2011-0386. Epub 2011 Dec 16.

PMID:
22180306
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Stereotactic hypofractionated radiation therapy as a bridge to transplantation for hepatocellular carcinoma: clinical outcome and pathologic correlation.

Katz AW, Chawla S, Qu Z, Kashyap R, Milano MT, Hezel AF.

Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):895-900. doi: 10.1016/j.ijrobp.2011.08.032. Epub 2011 Dec 13.

PMID:
22172906
[PubMed - indexed for MEDLINE]
17.

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.

Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA.

Cancer Discov. 2011 Jul;1(2):158-69. doi: 10.1158/2159-8290.CD-11-0031. Epub 2011 May 23.

PMID:
21984975
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.

Faris JE, Arnott J, Zheng H, Ryan DP, Abrams TA, Blaszkowsky LS, Clark JW, Enzinger PC, Hezel AF, Ng K, Wolpin BM, Kwak EL.

Invest New Drugs. 2012 Aug;30(4):1614-20. doi: 10.1007/s10637-011-9708-3. Epub 2011 Jul 29.

PMID:
21800081
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma.

Deshpande V, Nduaguba A, Zimmerman SM, Kehoe SM, Macconaill LE, Lauwers GY, Ferrone C, Bardeesy N, Zhu AX, Hezel AF.

BMC Cancer. 2011 Feb 8;11:60. doi: 10.1186/1471-2407-11-60.

PMID:
21303542
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Development of molecularly targeted therapies in biliary tract cancers: reassessing the challenges and opportunities.

Zhu AX, Hezel AF.

Hepatology. 2011 Feb;53(2):695-704. doi: 10.1002/hep.24145. Review.

PMID:
21274890
[PubMed - indexed for MEDLINE]

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