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Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial.

Bijlsma JW, Welsing PM, Woodworth TG, Middelink LM, Pethö-Schramm A, Bernasconi C, Borm ME, Wortel CH, ter Borg EJ, Jahangier ZN, van der Laan WH, Bruyn GA, Baudoin P, Wijngaarden S, Vos PA, Bos R, Starmans MJ, Griep EN, Griep-Wentink JR, Allaart CF, Heurkens AH, Teitsma XM, Tekstra J, Marijnissen AC, Lafeber FP, Jacobs JW.

Lancet. 2016 Jul 23;388(10042):343-55. doi: 10.1016/S0140-6736(16)30363-4. Epub 2016 Jun 7.


Prevalence of methotrexate intolerance in rheumatoid arthritis and psoriatic arthritis.

Ćalasan MB, van den Bosch OF, Creemers MC, Custers M, Heurkens AH, van Woerkom JM, Wulffraat NM.

Arthritis Res Ther. 2013;15(6):R217.


[Guideline 'Diagnostics of small-vessel vasculitis'].

Thio HB, Balak DM, Meilof JF, Stegeman CA, Voskuyl AE; 'Consensus diagnostic small-vessel vasculitis' Workgroup.

Ned Tijdschr Geneeskd. 2012;156(21):A4317. Dutch.


Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial.

Bakker MF, Jacobs JW, Welsing PM, Verstappen SM, Tekstra J, Ton E, Geurts MA, van der Werf JH, van Albada-Kuipers GA, Jahangier-de Veen ZN, van der Veen MJ, Verhoef CM, Lafeber FP, Bijlsma JW; Utrecht Rheumatoid Arthritis Cohort Study Group.

Ann Intern Med. 2012 Mar 6;156(5):329-39. doi: 10.7326/0003-4819-156-5-201203060-00004.


Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry.

Denton CP, Krieg T, Guillevin L, Schwierin B, Rosenberg D, Silkey M, Zultak M, Matucci-Cerinic M; DUO Registry investigators.

Ann Rheum Dis. 2012 May;71(5):718-21. doi: 10.1136/annrheumdis-2011-200631. Epub 2012 Jan 12.


Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study.

Verstappen SM, Bakker MF, Heurkens AH, van der Veen MJ, Kruize AA, Geurts MA, Bijlsma JW, Jacobs JW; Utrecht Rheumatoid Arthritis Cohort Study Group.

Ann Rheum Dis. 2010 Jun;69(6):1044-8. doi: 10.1136/ard.2008.106617. Epub 2009 Jul 5.


[Swelling of the sternocostoclavicular joint. Not always worrysome].

Opstelten W, Heggelman BG, Rijsman P, Heurkens AH.

Ned Tijdschr Geneeskd. 2009 Jan 31;153(5):196-200. Dutch. No abstract available.


Cartilage proteoglycan aggrecan epitopes induce proinflammatory autoreactive T-cell responses in rheumatoid arthritis and osteoarthritis.

de Jong H, Berlo SE, Hombrink P, Otten HG, van Eden W, Lafeber FP, Heurkens AH, Bijlsma JW, Glant TT, Prakken BJ.

Ann Rheum Dis. 2010 Jan;69(1):255-62. doi: 10.1136/ard.2008.103978. Epub .


Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial).

Verstappen SM, Jacobs JW, van der Veen MJ, Heurkens AH, Schenk Y, ter Borg EJ, Blaauw AA, Bijlsma JW; Utrecht Rheumatoid Arthritis Cohort study group.

Ann Rheum Dis. 2007 Nov;66(11):1443-9. Epub 2007 May 22.


Determinants of direct costs in Dutch rheumatoid arthritis patients.

Verstappen SM, Verkleij H, Bijlsma JW, Buskens E, Kruize AA, Heurkens AH, Van Der Veen MJ, Jacobs JW.

Ann Rheum Dis. 2004 Jul;63(7):817-24.


Five-year followup of rheumatoid arthritis patients after early treatment with disease-modifying antirheumatic drugs versus treatment according to the pyramid approach in the first year.

Verstappen SM, Jacobs JW, Bijlsma JW, Heurkens AH, van Booma-Frankfort C, Borg EJ, Hofman DM, van der Veen MJ; Utrecht Arthritis Cohort Study Group.

Arthritis Rheum. 2003 Jul;48(7):1797-807.


Aggressive treatment in early rheumatoid arthritis: a randomised controlled trial. On behalf of the Rheumatic Research Foundation Utrecht, The Netherlands.

van Jaarsveld CH, Jacobs JW, van der Veen MJ, Blaauw AA, Kruize AA, Hofman DM, Brus HL, van Albada-Kuipers GA, Heurkens AH, ter Borg EJ, Haanen HC, van Booma-Frankfort C, Schenk Y, Bijlsma JW.

Ann Rheum Dis. 2000 Jun;59(6):468-77.


Direct cost of rheumatoid arthritis during the first six years: a cost-of-illness study.

van Jaarsveld CH, Jacobs JW, Schrijvers AJ, Heurkens AH, Haanen HC, Bijlsma JW.

Br J Rheumatol. 1998 Aug;37(8):837-47.


The effectiveness of early treatment with "second-line" antirheumatic drugs. A randomized, controlled trial.

van der Heide A, Jacobs JW, Bijlsma JW, Heurkens AH, van Booma-Frankfort C, van der Veen MJ, Haanen HC, Hofman DM, van Albada-Kuipers GA, ter Borg EJ, Brus HL, Dinant HJ, Kruize AA, Schenk Y.

Ann Intern Med. 1996 Apr 15;124(8):699-707.


Prednisone plus azathioprine treatment in patients with rheumatoid arthritis complicated by vasculitis.

Heurkens AH, Westedt ML, Breedveld FC.

Arch Intern Med. 1991 Nov;151(11):2249-54.


Characterization of anti-endothelial antibodies in patients with rheumatoid arthritis complicated by vasculitis.

van der Zee JM, Heurkens AH, van der Voort EA, Daha MR, Breedveld FC.

Clin Exp Rheumatol. 1991 Nov-Dec;9(6):589-94.


Methods for the detection of anti-endothelial antibodies by enzyme-linked immunosorbent assay.

Heurkens AH, Gorter A, de Vreede TM, Edgell CS, Breedveld FC, Daha MR.

J Immunol Methods. 1991 Jul 26;141(1):33-9.


Polyneuropathy as initial manifestation of necrotizing vasculitis and gangrene in systemic lupus erythematosus.

Markusse HM, Vroom TM, Heurkens AH, Vecht CJ.

Neth J Med. 1991 Jun;38(5-6):204-8.


Uptake and degradation of soluble aggregates of IgG by monocytes of patients with rheumatoid arthritis: relation to disease activity.

Heurkens AH, Westedt ML, Breedveld FC, Jonges E, Cats A, Stijnen T, Daha MR.

Ann Rheum Dis. 1991 May;50(5):284-9.


Degradation of aggregates of activated C3 (C3b) by monocytes of patients with rheumatoid arthritis is related to vasculitis.

Heurkens AH, Breedveld FC, Keur CV, Brand R, Daha MR.

Clin Exp Immunol. 1990 May;80(2):177-80.

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