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Items: 1 to 20 of 92

1.

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.

Götz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zühlke K, Kreuchwig A, Kennedy E, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E.

Biochem J. 2016 Apr 21. pii: BCJ20160242. [Epub ahead of print]

PMID:
27102985
2.

Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.

Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel DE, Herberg FW, Kim C.

Structure. 2016 May 3;24(5):710-20. doi: 10.1016/j.str.2016.03.009. Epub 2016 Apr 7.

PMID:
27066748
3.

Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.

Kibat J, Schirrmann T, Knape MJ, Helmsing S, Meier D, Hust M, Schröder C, Bertinetti D, Winter G, Pardes K, Funk M, Vala A, Giese N, Herberg FW, Dübel S, Hoheisel JD.

N Biotechnol. 2016 Sep 25;33(5 Pt A):574-81. doi: 10.1016/j.nbt.2015.12.003. Epub 2015 Dec 17.

4.

Defining A-Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA-RI).

Autenrieth K, Bendzunas NG, Bertinetti D, Herberg FW, Kennedy EJ.

Chembiochem. 2016 Apr 15;17(8):693-7. doi: 10.1002/cbic.201500632. Epub 2015 Dec 17.

PMID:
26611881
5.

Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).

VanSchouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg FW, Kim C, Melacini G.

J Biol Chem. 2015 Nov 27;290(48):28631-41. doi: 10.1074/jbc.M115.685305. Epub 2015 Sep 14.

PMID:
26370085
6.

Application of Synthetic Peptide Arrays To Uncover Cyclic Di-GMP Binding Motifs.

Düvel J, Bense S, Möller S, Bertinetti D, Schwede F, Morr M, Eckweiler D, Genieser HG, Jänsch L, Herberg FW, Frank R, Häussler S.

J Bacteriol. 2015 Aug 31;198(1):138-46. doi: 10.1128/JB.00377-15.

7.

Divalent Metal Ions Mg²⁺ and Ca²⁺ Have Distinct Effects on Protein Kinase A Activity and Regulation.

Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor SS, Herberg FW.

ACS Chem Biol. 2015 Oct 16;10(10):2303-15. doi: 10.1021/acschembio.5b00271. Epub 2015 Aug 5.

PMID:
26200257
8.

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.

Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS.

PLoS Biol. 2015 Jul 9;13(7):e1002192. doi: 10.1371/journal.pbio.1002192. eCollection 2015 Jul.

9.

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.

Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2015 Jul;29(7):988-1005. doi: 10.1210/me.2014-1330. Epub 2015 Jun 10.

PMID:
26061564
10.

Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein.

Hermann JS, Skroblin P, Bertinetti D, Hanold LE, von der Heide EK, Wagener EM, Zenn HM, Klussmann E, Kennedy EJ, Herberg FW.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1667-75. doi: 10.1016/j.bbapap.2015.04.018. Epub 2015 Apr 23.

PMID:
25916936
11.

FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases.

Manoharan GB, Enkvist E, Kasari M, Viht K, Zenn M, Prinz A, Filhol O, Herberg FW, Uri A.

Anal Biochem. 2015 Jul 15;481:10-7. doi: 10.1016/j.ab.2015.04.009. Epub 2015 Apr 10.

PMID:
25866074
12.

Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design.

Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1575-85. doi: 10.1016/j.bbapap.2015.03.012. Epub 2015 Apr 3.

PMID:
25847873
13.

PKA-type I selective constrained peptide disruptors of AKAP complexes.

Wang Y, Ho TG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE, Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ.

ACS Chem Biol. 2015 Jun 19;10(6):1502-10. doi: 10.1021/acschembio.5b00009. Epub 2015 Mar 25.

14.

Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress.

Kim JJ, Flueck C, Franz E, Sanabria-Figueroa E, Thompson E, Lorenz R, Bertinetti D, Baker DA, Herberg FW, Kim C.

PLoS Pathog. 2015 Feb 3;11(2):e1004639. doi: 10.1371/journal.ppat.1004639. eCollection 2015 Feb.

15.

Structure-guided design of selective Epac1 and Epac2 agonists.

Schwede F, Bertinetti D, Langerijs CN, Hadders MA, Wienk H, Ellenbroek JH, de Koning EJ, Bos JL, Herberg FW, Genieser HG, Janssen RA, Rehmann H.

PLoS Biol. 2015 Jan 20;13(1):e1002038. doi: 10.1371/journal.pbio.1002038. eCollection 2015 Jan.

16.

Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

Möller S, Alfieri A, Bertinetti D, Aquila M, Schwede F, Lolicato M, Rehmann H, Moroni A, Herberg FW.

ACS Chem Biol. 2014 May 16;9(5):1128-37. doi: 10.1021/cb400904s. Epub 2014 Mar 7.

PMID:
24605759
17.

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.

Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutiérrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Müller S.

Biochem J. 2014 Apr 1;459(1):59-69. doi: 10.1042/BJ20131399.

18.

Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides.

Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GC, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ.

ACS Chem Biol. 2014 Mar 21;9(3):635-42. doi: 10.1021/cb400900r. Epub 2014 Jan 21. Erratum in: ACS Chem Biol. 2014 Jun 20;9(6):1386.

19.

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.

Muda K, Bertinetti D, Gesellchen F, Hermann JS, von Zweydorf F, Geerlof A, Jacob A, Ueffing M, Gloeckner CJ, Herberg FW.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E34-43. doi: 10.1073/pnas.1312701111. Epub 2013 Dec 18.

20.

Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I.

Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C.

Structure. 2014 Jan 7;22(1):116-24. doi: 10.1016/j.str.2013.09.021. Epub 2013 Nov 14.

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