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Items: 18


A systems biology approach reveals the dose- and time-dependent effect of primary human airway epithelium tissue culture after exposure to cigarette smoke in vitro.

Mathis C, Gebel S, Poussin C, Belcastro V, Sewer A, Weisensee D, Hengstermann A, Ansari S, Wagner S, Peitsch MC, Hoeng J.

Bioinform Biol Insights. 2015 Mar 9;9:19-35. doi: 10.4137/BBI.S19908. eCollection 2015.


Assessment of a novel multi-array normalization method based on spike-in control probes suitable for microRNA datasets with global decreases in expression.

Sewer A, Gubian S, Kogel U, Veljkovic E, Han W, Hengstermann A, Peitsch MC, Hoeng J.

BMC Res Notes. 2014 May 17;7:302. doi: 10.1186/1756-0500-7-302.


A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue.

Westra JW, Schlage WK, Hengstermann A, Gebel S, Mathis C, Thomson T, Wong B, Hoang V, Veljkovic E, Peck M, Lichtner RB, Weisensee D, Talikka M, Deehan R, Hoeng J, Peitsch MC.

Bioinform Biol Insights. 2013 Jun 20;7:167-92. doi: 10.4137/BBI.S11509. Print 2013.


Construction of a computable network model for DNA damage, autophagy, cell death, and senescence.

Gebel S, Lichtner RB, Frushour B, Schlage WK, Hoang V, Talikka M, Hengstermann A, Mathis C, Veljkovic E, Peck M, Peitsch MC, Deehan R, Hoeng J, Westra JW.

Bioinform Biol Insights. 2013;7:97-117. doi: 10.4137/BBI.S11154. Epub 2013 Mar 7.


Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers.

Mathis C, Poussin C, Weisensee D, Gebel S, Hengstermann A, Sewer A, Belcastro V, Xiang Y, Ansari S, Wagner S, Hoeng J, Peitsch MC.

Am J Physiol Lung Cell Mol Physiol. 2013 Apr 1;304(7):L489-503. doi: 10.1152/ajplung.00181.2012. Epub 2013 Jan 25.


Nrf2: friend and foe in preventing cigarette smoking-dependent lung disease.

Müller T, Hengstermann A.

Chem Res Toxicol. 2012 Sep 17;25(9):1805-24. doi: 10.1021/tx300145n. Epub 2012 Jun 22. Review.


A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue.

Schlage WK, Westra JW, Gebel S, Catlett NL, Mathis C, Frushour BP, Hengstermann A, Van Hooser A, Poussin C, Wong B, Lietz M, Park J, Drubin D, Veljkovic E, Peitsch MC, Hoeng J, Deehan R.

BMC Syst Biol. 2011 Oct 19;5:168. doi: 10.1186/1752-0509-5-168.


Construction of a computable cell proliferation network focused on non-diseased lung cells.

Westra JW, Schlage WK, Frushour BP, Gebel S, Catlett NL, Han W, Eddy SF, Hengstermann A, Matthews AL, Mathis C, Lichtner RB, Poussin C, Talikka M, Veljkovic E, Van Hooser AA, Wong B, Maria MJ, Peitsch MC, Deehan R, Hoeng J.

BMC Syst Biol. 2011 Jul 2;5:105. doi: 10.1186/1752-0509-5-105.


Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival.

Hengstermann A, Müller T.

Free Radic Biol Med. 2008 Mar 15;44(6):1097-107. doi: 10.1016/j.freeradbiomed.2007.12.009. Epub 2007 Dec 23.


Characterization of Nrf2 activation and heme oxygenase-1 expression in NIH3T3 cells exposed to aqueous extracts of cigarette smoke.

Knörr-Wittmann C, Hengstermann A, Gebel S, Alam J, Müller T.

Free Radic Biol Med. 2005 Dec 1;39(11):1438-48. Epub 2005 Aug 19.


Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.

Hengstermann A, D'silva MA, Kuballa P, Butz K, Hoppe-Seyler F, Scheffner M.

J Virol. 2005 Jul;79(14):9296-300.


Involvement of the DNA repair protein hHR23 in p53 degradation.

Glockzin S, Ogi FX, Hengstermann A, Scheffner M, Blattner C.

Mol Cell Biol. 2003 Dec;23(24):8960-9.


HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

Linares LK, Hengstermann A, Ciechanover A, Müller S, Scheffner M.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12009-14. Epub 2003 Sep 24.


siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells.

Butz K, Ristriani T, Hengstermann A, Denk C, Scheffner M, Hoppe-Seyler F.

Oncogene. 2003 Sep 4;22(38):5938-45.


Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.

Hengstermann A, Linares LK, Ciechanover A, Whitaker NJ, Scheffner M.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1218-23. Epub 2001 Jan 23.


Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

Gostissa M, Hengstermann A, Fogal V, Sandy P, Schwarz SE, Scheffner M, Del Sal G.

EMBO J. 1999 Nov 15;18(22):6462-71.


Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation.

Hengstermann A, Whitaker NJ, Zimmer D, Zentgraf H, Scheffner M.

Oncogene. 1998 Dec 3;17(22):2933-41.


Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells.

Rothmann T, Hengstermann A, Whitaker NJ, Scheffner M, zur Hausen H.

J Virol. 1998 Dec;72(12):9470-8.

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