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Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.

Grzmil M, Seebacher J, Hess D, Behe M, Schibli R, Moncayo G, Frank S, Hemmings BA.

Cell Signal. 2016 Sep;28(9):1412-21. doi: 10.1016/j.cellsig.2016.06.005. Epub 2016 Jun 8.


Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling.

Wicki A, Mandalà M, Massi D, Taverna D, Tang H, Hemmings BA, Xue G.

Physiol Rev. 2016 Jul;96(3):805-29. doi: 10.1152/physrev.00024.2015. Review.


The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.

Tang F, Gill J, Ficht X, Barthlott T, Cornils H, Schmitz-Rohmer D, Hynx D, Zhou D, Zhang L, Xue G, Grzmil M, Yang Z, Hergovich A, Hollaender GA, Stein JV, Hemmings BA, Matthias P.

Sci Signal. 2015 Oct 6;8(397):ra100. doi: 10.1126/scisignal.aab2425.


NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development.

Schmitz-Rohmer D, Probst S, Yang ZZ, Laurent F, Stadler MB, Zuniga A, Zeller R, Hynx D, Hemmings BA, Hergovich A.

PLoS One. 2015 Aug 25;10(8):e0136566. doi: 10.1371/journal.pone.0136566. eCollection 2015.


Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy.

Xue G, Zippelius A, Wicki A, Mandalà M, Tang F, Massi D, Hemmings BA.

J Natl Cancer Inst. 2015 Jun 11;107(7). pii: djv171. doi: 10.1093/jnci/djv171. Print 2015 Jul. Review.


The PI3K-PKB/Akt pathway.

Hemmings BA, Restuccia DF.

Cold Spring Harb Perspect Biol. 2015 Apr 1;7(4). pii: a026609. doi: 10.1101/cshperspect.a026609. No abstract available.


All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.

Brand Y, Levano S, Radojevic V, Naldi AM, Setz C, Ryan AF, Pak K, Hemmings BA, Bodmer D.

PLoS One. 2015 Mar 26;10(3):e0121599. doi: 10.1371/journal.pone.0121599. eCollection 2015.


Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development.

Luo W, Zhao X, Jin H, Tao L, Zhu J, Wang H, Hemmings BA, Yang Z.

Development. 2015 Feb 15;142(4):732-42. doi: 10.1242/dev.119016.


NDR functions as a physiological YAP1 kinase in the intestinal epithelium.

Zhang L, Tang F, Terracciano L, Hynx D, Kohler R, Bichet S, Hess D, Cron P, Hemmings BA, Hergovich A, Schmitz-Rohmer D.

Curr Biol. 2015 Feb 2;25(3):296-305. doi: 10.1016/j.cub.2014.11.054. Epub 2015 Jan 15.


PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis.

Kim DK, Kim YH, Hynx D, Wang Y, Yang KJ, Ryu D, Kim KS, Yoo EK, Kim JS, Koo SH, Lee IK, Chae HZ, Park J, Lee CH, Biddinger SB, Hemmings BA, Choi HS.

Diabetologia. 2014 Dec;57(12):2576-85. doi: 10.1007/s00125-014-3366-x. Epub 2014 Sep 10.


hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.

Tang F, Zhang L, Xue G, Hynx D, Wang Y, Cron PD, Hundsrucker C, Hergovich A, Frank S, Hemmings BA, Schmitz-Rohmer D.

Cancer Res. 2014 Jul 15;74(14):3779-89. doi: 10.1158/0008-5472.CAN-13-3430. Epub 2014 May 28.


Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.

Schultze SM, Dietrich M, Hynx D, Geier A, Niessen M, Spinas GA, Hemmings BA, Tschopp O.

Liver Int. 2015 Apr;35(4):1354-66. doi: 10.1111/liv.12600. Epub 2014 Jun 24.


Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα-/-) in vivo model.

Eberle C, Niessen M, Hemmings BA, Tschopp O, Ament C.

Arch Physiol Biochem. 2014 Jul;120(3):91-8. doi: 10.3109/13813455.2014.911330. Epub 2014 Apr 28.


MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA.

J Clin Invest. 2014 Feb;124(2):742-54. doi: 10.1172/JCI70198. Epub 2014 Jan 9.


Multimodal imaging reveals a role for Akt1 in fetal cardiac development.

Vandoorne K, Vandsburger MH, Weisinger K, Brumfeld V, Hemmings BA, Harmelin A, Neeman M.

Physiol Rep. 2013 Nov;1(6):e00143. doi: 10.1002/phy2.143. Epub 2013 Nov 7.


Chronic Akt1 deficiency attenuates adverse remodeling and enhances angiogenesis after myocardial infarction.

Vandoorne K, Vandsburger MH, Raz T, Shalev M, Weisinger K, Biton I, Brumfeld V, Raanan C, Nevo N, Eilam R, Hemmings BA, Tzahor E, Harmelin A, Gepstein L, Neeman M.

Circ Cardiovasc Imaging. 2013 Nov;6(6):992-1000. doi: 10.1161/CIRCIMAGING.113.000828. Epub 2013 Oct 17.


Characterization of fragmented 3-phosphoinsitide-dependent protein kinase-1 (PDK1) by phosphosite-specific antibodies.

Park J, Li Y, Kim SH, Kong G, Shrestha R, Tran Q, Hong J, Hur GM, Hemmings BA, Koo BS, Park J.

Life Sci. 2013 Nov 4;93(18-19):700-6. doi: 10.1016/j.lfs.2013.09.007. Epub 2013 Sep 15.


Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.

Green BD, Jabbour AM, Sandow JJ, Riffkin CD, Masouras D, Daunt CP, Salmanidis M, Brumatti G, Hemmings BA, Guthridge MA, Pearson RB, Ekert PG.

Cell Death Differ. 2013 Oct;20(10):1341-9. doi: 10.1038/cdd.2013.63. Epub 2013 Jun 21.


Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival.

Huber RM, Rajski M, Sivasankaran B, Moncayo G, Hemmings BA, Merlo A.

PLoS One. 2013;8(2):e57793. doi: 10.1371/journal.pone.0057793. Epub 2013 Feb 25.


Overcoming resistance to rapalogs in gliomas by combinatory therapies.

Grzmil M, Hemmings BA.

Biochim Biophys Acta. 2013 Jul;1834(7):1371-80. doi: 10.1016/j.bbapap.2013.01.041. Epub 2013 Feb 8. Review.

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