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Results: 1 to 20 of 31

1.

Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients.

Bartram I, Gökbuget N, Schlee C, Heesch S, Fransecky L, Schwartz S, Stuhlmann R, Schäfer-Eckhart K, Starck M, Reichle A, Hoelzer D, Baldus CD, Neumann M.

J Hematol Oncol. 2014 Jul 15;7:51. doi: 10.1186/s13045-014-0051-y.

PMID:
25023966
[PubMed - in process]
Free Article
2.

FAT1 expression and mutations in adult acute lymphoblastic leukemia.

Neumann M, Seehawer M, Schlee C, Vosberg S, Heesch S, von der Heide EK, Graf A, Krebs S, Blum H, Gökbuget N, Schwartz S, Hoelzer D, Greif PA, Baldus CD.

Blood Cancer J. 2014 Jun 27;4:e224. doi: 10.1038/bcj.2014.44. No abstract available.

PMID:
24972153
[PubMed - in process]
Free PMC Article
3.

Severity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation.

Nordell AD, McKenna M, Borges ÁH, Duprez D, Neuhaus J, Neaton JD; INSIGHT SMART, ESPRIT Study Groups; SILCAAT Scientific Committee.

J Am Heart Assoc. 2014 May 28;3(3):e000844. doi: 10.1161/JAHA.114.000844.

PMID:
24870935
[PubMed - in process]
Free Article
4.

Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors.

Kemmeren P, Sameith K, van de Pasch LA, Benschop JJ, Lenstra TL, Margaritis T, O'Duibhir E, Apweiler E, van Wageningen S, Ko CW, van Heesch S, Kashani MM, Ampatziadis-Michailidis G, Brok MO, Brabers NA, Miles AJ, Bouwmeester D, van Hooff SR, van Bakel H, Sluiters E, Bakker LV, Snel B, Lijnzaad P, van Leenen D, Groot Koerkamp MJ, Holstege FC.

Cell. 2014 Apr 24;157(3):740-52. doi: 10.1016/j.cell.2014.02.054.

PMID:
24766815
[PubMed - indexed for MEDLINE]
5.

Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes.

van Heesch S, van Iterson M, Jacobi J, Boymans S, Essers PB, de Bruijn E, Hao W, MacInnes AW, Cuppen E, Simonis M.

Genome Biol. 2014 Jan 7;15(1):R6. doi: 10.1186/gb-2014-15-1-r6.

PMID:
24393600
[PubMed - in process]
Free PMC Article
6.

Quantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysis.

Low TY, van Heesch S, van den Toorn H, Giansanti P, Cristobal A, Toonen P, Schafer S, Hübner N, van Breukelen B, Mohammed S, Cuppen E, Heck AJ, Guryev V.

Cell Rep. 2013 Dec 12;5(5):1469-78. doi: 10.1016/j.celrep.2013.10.041. Epub 2013 Nov 27.

PMID:
24290761
[PubMed - indexed for MEDLINE]
Free Article
7.

Intracellular eukaryotic pathogens in brown macroalgae in the Eastern Mediterranean, including LSU rRNA data for the oomycete Eurychasma dicksonii .

Strittmatter M, Gachon CM, Müller DG, Kleinteich J, Heesch S, Tsirigoti A, Katsaros C, Kostopoulou M, Küpper FC.

Dis Aquat Organ. 2013 Apr 29;104(1):1-11. doi: 10.3354/dao02583.

PMID:
23670075
[PubMed - indexed for MEDLINE]
8.

Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain.

van Nuland R, van Schaik FM, Simonis M, van Heesch S, Cuppen E, Boelens R, Timmers HM, van Ingen H.

Epigenetics Chromatin. 2013 May 8;6(1):12. doi: 10.1186/1756-8935-6-12.

PMID:
23656834
[PubMed]
Free PMC Article
9.

Systematic biases in DNA copy number originate from isolation procedures.

van Heesch S, Mokry M, Boskova V, Junker W, Mehon R, Toonen P, de Bruijn E, Shull JD, Aitman TJ, Cuppen E, Guryev V.

Genome Biol. 2013 Apr 24;14(4):R33. doi: 10.1186/gb-2013-14-4-r33.

PMID:
23618369
[PubMed - in process]
Free PMC Article
10.

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.

Neumann M, Heesch S, Schlee C, Schwartz S, Gökbuget N, Hoelzer D, Konstandin NP, Ksienzyk B, Vosberg S, Graf A, Krebs S, Blum H, Raff T, Brüggemann M, Hofmann WK, Hecht J, Bohlander SK, Greif PA, Baldus CD.

Blood. 2013 Jun 6;121(23):4749-52. doi: 10.1182/blood-2012-11-465138. Epub 2013 Apr 19.

PMID:
23603912
[PubMed - indexed for MEDLINE]
Free Article
11.

Improving mammalian genome scaffolding using large insert mate-pair next-generation sequencing.

van Heesch S, Kloosterman WP, Lansu N, Ruzius FP, Levandowsky E, Lee CC, Zhou S, Goldstein S, Schwartz DC, Harkins TT, Guryev V, Cuppen E.

BMC Genomics. 2013 Apr 16;14:257. doi: 10.1186/1471-2164-14-257.

PMID:
23590730
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia.

Coskun E, Neumann M, Schlee C, Liebertz F, Heesch S, Goekbuget N, Hoelzer D, Baldus CD.

Leuk Res. 2013 Jun;37(6):647-56. doi: 10.1016/j.leukres.2013.02.019. Epub 2013 Mar 20.

PMID:
23522449
[PubMed - indexed for MEDLINE]
13.

Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization.

Heesch S, Neumann M, Schwartz S, Bartram I, Schlee C, Burmeister T, Hänel M, Ganser A, Heuser M, Wendtner CM, Berdel WE, Gökbuget N, Hoelzer D, Hofmann WK, Thiel E, Baldus CD.

Ann Hematol. 2013 Jun;92(6):747-58. doi: 10.1007/s00277-013-1694-4. Epub 2013 Feb 15.

PMID:
23412561
[PubMed - indexed for MEDLINE]
14.

FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors.

Neumann M, Coskun E, Fransecky L, Mochmann LH, Bartram I, Sartangi NF, Heesch S, Gökbuget N, Schwartz S, Brandts C, Schlee C, Haas R, Dührsen U, Griesshammer M, Döhner H, Ehninger G, Burmeister T, Blau O, Thiel E, Hoelzer D, Hofmann WK, Baldus CD.

PLoS One. 2013;8(1):e53190. doi: 10.1371/journal.pone.0053190. Epub 2013 Jan 24.

PMID:
23359050
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations.

Neumann M, Heesch S, Gökbuget N, Schwartz S, Schlee C, Benlasfer O, Farhadi-Sartangi N, Thibaut J, Burmeister T, Hoelzer D, Hofmann WK, Thiel E, Baldus CD.

Blood Cancer J. 2012 Jan;2(1):e55. doi: 10.1038/bcj.2011.49. Epub 2012 Jan 27.

PMID:
22829239
[PubMed]
Free PMC Article
16.

Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia.

Kaiser M, Kühnl A, Reins J, Fischer S, Ortiz-Tanchez J, Schlee C, Mochmann LH, Heesch S, Benlasfer O, Hofmann WK, Thiel E, Baldus CD.

Blood Cancer J. 2011 Jul;1(7):e28. doi: 10.1038/bcj.2011.28. Epub 2011 Jul 15.

PMID:
22829184
[PubMed]
Free PMC Article
17.

Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel.

Simonis M, Atanur SS, Linsen S, Guryev V, Ruzius FP, Game L, Lansu N, de Bruijn E, van Heesch S, Jones SJ, Pravenec M, Aitman TJ, Cuppen E.

Genome Biol. 2012 Apr 27;13(4):r31. doi: 10.1186/gb-2012-13-4-r31.

PMID:
22541052
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

High expression of IGFBP2 is associated with chemoresistance in adult acute myeloid leukemia.

Kühnl A, Kaiser M, Neumann M, Fransecky L, Heesch S, Radmacher M, Marcucci G, Bloomfield CD, Hofmann WK, Thiel E, Baldus CD.

Leuk Res. 2011 Dec;35(12):1585-90. doi: 10.1016/j.leukres.2011.08.006. Epub 2011 Sep 6.

PMID:
21899885
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.

van Boxtel R, Kuiper RV, Toonen PW, van Heesch S, Hermsen R, de Bruin A, Cuppen E.

Am J Pathol. 2011 Oct;179(4):1616-22. doi: 10.1016/j.ajpath.2011.06.036. Epub 2011 Aug 18.

PMID:
21854749
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The specificity and topology of chromatin interaction pathways in yeast.

Lenstra TL, Benschop JJ, Kim T, Schulze JM, Brabers NA, Margaritis T, van de Pasch LA, van Heesch SA, Brok MO, Groot Koerkamp MJ, Ko CW, van Leenen D, Sameith K, van Hooff SR, Lijnzaad P, Kemmeren P, Hentrich T, Kobor MS, Buratowski S, Holstege FC.

Mol Cell. 2011 May 20;42(4):536-49. doi: 10.1016/j.molcel.2011.03.026.

PMID:
21596317
[PubMed - indexed for MEDLINE]
Free Article

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