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A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes.

Arndt T, Wedekind D, Jörns A, Tsiavaliaris G, Cuppen E, Hedrich HJ, Lenzen S.

Diabetologia. 2015 Dec;58(12):2800-9. doi: 10.1007/s00125-015-3757-7. Epub 2015 Sep 12.


Variable immune cell frequencies in peripheral blood of LEW.1AR1-iddm rats over time compared to other congenic LEW strains.

Arndt T, Jörns A, Hedrich HJ, Lenzen S, Wedekind D.

Clin Exp Immunol. 2014 Jul;177(1):168-78. doi: 10.1111/cei.12323.


Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes.

Jörns A, Akin M, Arndt T, Terbish T, Zu Vilsendorf AM, Wedekind D, Hedrich HJ, Lenzen S.

J Mol Med (Berl). 2014 Jul;92(7):743-55. doi: 10.1007/s00109-014-1137-2. Epub 2014 Mar 7.


Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes.

Jörns A, Arndt T, Meyer zu Vilsendorf A, Klempnauer J, Wedekind D, Hedrich HJ, Marselli L, Marchetti P, Harada N, Nakaya Y, Wang GS, Scott FW, Gysemans C, Mathieu C, Lenzen S.

Diabetologia. 2014 Mar;57(3):512-21. doi: 10.1007/s00125-013-3125-4. Epub 2013 Dec 6.


Systemic treatment with 4-211Atphenylalanine enhances survival of rats with intracranial glioblastoma.

Borrmann N, Friedrich S, Schwabe K, Hedrich HJ, Krauss JK, Knapp WH, Nakamura M, Meyer GJ, Walte A.

Nuklearmedizin. 2013 Dec 13;52(6):212-21. doi: 10.3413/Nukmed-0580-13-05. Epub 2013 Sep 6.


A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat.

Arndt T, Jörns A, Weiss H, Tiedge M, Hedrich HJ, Lenzen S, Wedekind D.

PLoS One. 2013 May 22;8(5):e64305. doi: 10.1371/journal.pone.0064305. Print 2013.


Vocal correlates of sender-identity and arousal in the isolation calls of domestic kitten (Felis silvestris catus).

Scheumann M, Roser AE, Konerding W, Bleich E, Hedrich HJ, Zimmermann E.

Front Zool. 2012 Dec 21;9(1):36. doi: 10.1186/1742-9994-9-36.


Magnetic resonance imaging of soft tissue infection with iron oxide labeled granulocytes in a rat model.

Baraki H, Zinne N, Wedekind D, Meier M, Bleich A, Glage S, Hedrich HJ, Kutschka I, Haverich A.

PLoS One. 2012;7(12):e51770. doi: 10.1371/journal.pone.0051770. Epub 2012 Dec 7.


Treatment of male mice with gonadotropins to improve the fertilization rate and reproduction.

Glage S, Wittur I, Elfers C, Hedrich HJ, Dorsch M.

Lab Anim. 2013 Jan;47(1):26-30. doi: 10.1258/la.2012.012099. Epub 2012 Dec 10.


Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat.

Zschemisch NH, Glage S, Wedekind D, Weinstein EJ, Cui X, Dorsch M, Hedrich HJ.

BMC Immunol. 2012 Nov 8;13:60. doi: 10.1186/1471-2172-13-60.


Identification of an MHC class I ligand for the single member of a killer cell lectin-like receptor family, KLRH1.

Daws MR, Dai KZ, Zinöcker S, Naper C, Kveberg L, Hedrich HJ, Rolstad B, Vaage JT.

J Immunol. 2012 Dec 1;189(11):5178-84. doi: 10.4049/jimmunol.1201983. Epub 2012 Oct 24.


The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders.

Northrup E, Zschemisch NH, Eisenblätter R, Glage S, Wedekind D, Cuppen E, Dorsch M, Hedrich HJ.

PLoS One. 2012;7(5):e38001. doi: 10.1371/journal.pone.0038001. Epub 2012 May 24.


Mice may become caught in nesting material.

Northrup E, Held N, Hedrich HJ, Bleich A.

Lab Anim (NY). 2012 May 21;41(6):147. doi: 10.1038/laban0612-147. No abstract available.


Comparative evaluation of establishing a human gut microbial community within rodent models.

Wos-Oxley M, Bleich A, Oxley AP, Kahl S, Janus LM, Smoczek A, Nahrstedt H, Pils MC, Taudien S, Platzer M, Hedrich HJ, Medina E, Pieper DH.

Gut Microbes. 2012 May-Jun;3(3):234-49. doi: 10.4161/gmic.19934. Epub 2012 May 1.


Quantitative phenotyping of inflammatory bowel disease in the IL-10-deficient mouse by use of noninvasive magnetic resonance imaging.

Michael S, Keubler LM, Smoczek A, Meier M, Gunzer F, Pöhlmann C, Krause-Buchholz U, Hedrich HJ, Bleich A.

Inflamm Bowel Dis. 2013 Jan;19(1):185-93. doi: 10.1002/ibd.23006.


Reversal of diabetes through gene therapy of diabetic rats by hepatic insulin expression via lentiviral transduction.

Elsner M, Terbish T, Jörns A, Naujok O, Wedekind D, Hedrich HJ, Lenzen S.

Mol Ther. 2012 May;20(5):918-26. doi: 10.1038/mt.2012.8. Epub 2012 Feb 21.


Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota-host interactions.

Büchler G, Wos-Oxley ML, Smoczek A, Zschemisch NH, Neumann D, Pieper DH, Hedrich HJ, Bleich A.

Inflamm Bowel Dis. 2012 May;18(5):943-54. doi: 10.1002/ibd.21895. Epub 2012 Jan 11.


A safety and toxicity assessment of the administration of multiple intracerebral injections of irinotecan or doxorubicin drug-eluting beads.

Held N, Lewis AL, Hedrich HJ, Brinker T, Glage S.

Clin Transl Oncol. 2011 Oct;13(10):742-6. doi: 10.1007/s12094-011-0726-6.


Paw preference is not affected by postural demand in a nonprimate mammal (Felis silvestris catus).

Konerding WS, Hedrich HJ, Bleich E, Zimmermann E.

J Comp Psychol. 2012 Feb;126(1):15-22. doi: 10.1037/a0024638. Epub 2011 Aug 15.


Therapeutic concentrations of glucagon-like peptide-1 in cerebrospinal fluid following cell-based delivery into the cerebral ventricles of cats.

Glage S, Klinge PM, Miller MC, Wallrapp C, Geigle P, Hedrich HJ, Brinker T.

Fluids Barriers CNS. 2011 May 17;8:18. doi: 10.1186/2045-8118-8-18.

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