Healing of fresh extraction sockets filled with bioactive glass particles: histological findings in humans

Clin Implant Dent Relat Res. 2014 Feb;16(1):145-53. doi: 10.1111/j.1708-8208.2012.00463.x. Epub 2012 Jun 12.

Abstract

Purpose: The aim of the present study was to histologically evaluate fresh human sockets filled with bioactive glass after 6 months of healing.

Materials and methods: In 13 patients, 32 single extraction sites in the anterior area underwent socket ridge preservation procedure (RPP) with a bioactive glass (BioRestore™, Inion Oy, Tampere, Finland). At implant installation, 22 bone cores were trephined out and processed for histomorphometric and immunohistochemical analysis.

Results: Newly formed immature bone around residual particles of bioactive glass was found in all 22 biopsies. The histomorphometry of the amount of bone, provisional matrix, and residual graft returned a mean ± SD value of 54 ± 31%, 37.9 ± 25.6%, and 8.1 ± 7.8, respectively, 6 months after RPP.

Conclusion: The use of this grafting material in fresh extraction sockets appears to delay the healing processes of the alveolar bone; therefore, its indication as a material for RPP when implant placement is considered within 6 months after extraction should be revised.

Trial registration: ClinicalTrials.gov NCT01105026.

Keywords: alveolar sites; bioactive glass; bone graft; bone regeneration; histology.

MeSH terms

  • Adult
  • Aged
  • Biocompatible Materials*
  • Female
  • Glass*
  • Humans
  • Male
  • Middle Aged
  • Tooth Extraction*
  • Tooth Socket*
  • Wound Healing*

Substances

  • Biocompatible Materials

Associated data

  • ClinicalTrials.gov/NCT01105026