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Items: 1 to 20 of 290

1.

Microtubules: 50 years on from the discovery of tubulin.

Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E.

Nat Rev Mol Cell Biol. 2016 Apr 22;17(5):322-8. doi: 10.1038/nrm.2016.45.

PMID:
27103327
2.

An ontogenetic approach to gynecologic malignancies.

Santiago IA, Gomes AP, Heald RJ.

Insights Imaging. 2016 Apr 15. [Epub ahead of print] Review.

PMID:
27084346
3.

A versatile multivariate image analysis pipeline reveals features of Xenopus extract spindles.

Grenfell AW, Strzelecka M, Crowder ME, Helmke KJ, Schlaitz AL, Heald R.

J Cell Biol. 2016 Apr 11;213(1):127-36. doi: 10.1083/jcb.201509079. Epub 2016 Apr 4.

PMID:
27044897
4.

Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Heald R, Bowman KK, Bryan MC, Burdick D, Chan B, Chan E, Chen Y, Clausen S, Dominguez-Fernandez B, Eigenbrot C, Elliott R, Hanan EJ, Jackson P, Knight J, La H, Lainchbury M, Malek S, Mann S, Merchant M, Mortara K, Purkey H, Schaefer G, Schmidt S, Seward E, Sideris S, Shao L, Wang S, Yeap K, Yen I, Yu C, Heffron TP.

J Med Chem. 2016 Mar 24;59(6):2848. doi: 10.1021/acs.jmedchem.6b00301. Epub 2016 Mar 11. No abstract available.

PMID:
26967667
5.

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

Bryan MC, Burdick DJ, Chan BK, Chen Y, Clausen S, Dotson J, Eigenbrot C, Elliott R, Hanan EJ, Heald R, Jackson P, La H, Lainchbury M, Malek S, Mann SE, Purkey HE, Schaefer G, Schmidt S, Seward E, Sideris S, Wang S, Yen I, Yu C, Heffron TP.

ACS Med Chem Lett. 2015 Dec 17;7(1):100-4. doi: 10.1021/acsmedchemlett.5b00428. eCollection 2016 Jan 14.

PMID:
26819674
6.

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

Heffron TP, Heald RA, Ndubaku C, Wei B, Augistin M, Do S, Edgar K, Eigenbrot C, Friedman L, Gancia E, Jackson PS, Jones G, Kolesnikov A, Lee LB, Lesnick JD, Lewis C, McLean N, Mörtl M, Nonomiya J, Pang J, Price S, Prior WW, Salphati L, Sideris S, Staben ST, Steinbacher S, Tsui V, Wallin J, Sampath D, Olivero AG.

J Med Chem. 2016 Feb 11;59(3):985-1002. doi: 10.1021/acs.jmedchem.5b01483. Epub 2016 Jan 20.

PMID:
26741947
7.

Thirty years of search and capture: The complex simplicity of mitotic spindle assembly.

Heald R, Khodjakov A.

J Cell Biol. 2015 Dec 21;211(6):1103-11. doi: 10.1083/jcb.201510015. Epub 2015 Dec 14. Review.

PMID:
26668328
8.

Robotic total mesorectal excision - precision surgery with even more precise tools.

Chand M, Heald RJ, Parvaiz A.

J R Soc Med. 2016 Feb;109(2):78-9. doi: 10.1177/0141076815617695. Epub 2015 Nov 25. No abstract available.

PMID:
26609124
9.

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Heald R, Bowman KK, Bryan MC, Burdick D, Chan B, Chan E, Chen Y, Clausen S, Dominguez-Fernandez B, Eigenbrot C, Elliott R, Hanan EJ, Jackson P, Knight J, La H, Lainchbury M, Malek S, Mann S, Merchant M, Mortara K, Purkey H, Schaefer G, Schmidt S, Seward E, Sideris S, Shao L, Wang S, Yeap K, Yen I, Yu C, Heffron TP.

J Med Chem. 2015 Nov 25;58(22):8877-95. doi: 10.1021/acs.jmedchem.5b01412. Epub 2015 Nov 12.

PMID:
26455919
10.

Biological Scaling Problems and Solutions in Amphibians.

Levy DL, Heald R.

Cold Spring Harb Perspect Biol. 2015 Aug 10;8(1):a019166. doi: 10.1101/cshperspect.a019166. Review.

PMID:
26261280
11.

Enzymatically Generated CRISPR Libraries for Genome Labeling and Screening.

Lane AB, Strzelecka M, Ettinger A, Grenfell AW, Wittmann T, Heald R.

Dev Cell. 2015 Aug 10;34(3):373-8. doi: 10.1016/j.devcel.2015.06.003. Epub 2015 Jul 23.

PMID:
26212133
12.

Transanal Total Mesorectal Excision for Rectal Cancer: Outcomes after 140 Patients.

Lacy AM, Tasende MM, Delgado S, Fernandez-Hevia M, Jimenez M, De Lacy B, Castells A, Bravo R, Wexner SD, Heald RJ.

J Am Coll Surg. 2015 Aug;221(2):415-23. doi: 10.1016/j.jamcollsurg.2015.03.046. Epub 2015 Mar 30.

PMID:
26206640
13.

A comparative analysis of spindle morphometrics across metazoans.

Crowder ME, Strzelecka M, Wilbur JD, Good MC, von Dassow G, Heald R.

Curr Biol. 2015 Jun 1;25(11):1542-50. doi: 10.1016/j.cub.2015.04.036. Epub 2015 May 21.

PMID:
26004761
14.

Glutamylation of Nap1 modulates histone H1 dynamics and chromosome condensation in Xenopus.

Miller KE, Heald R.

J Cell Biol. 2015 Apr 27;209(2):211-20. doi: 10.1083/jcb.201412097. Epub 2015 Apr 20.

15.

Structured training in robotic colorectal surgery.

Tou S, Bergamaschi R, Heald RJ, Parvaiz A.

Colorectal Dis. 2015 Mar;17(3):185. doi: 10.1111/codi.12898. No abstract available.

PMID:
25678329
16.

RUVs drive chromosome decondensation after mitosis.

Strzelecka M, Heald R.

Dev Cell. 2014 Nov 10;31(3):259-60. doi: 10.1016/j.devcel.2014.10.018. Epub 2014 Nov 10.

17.

Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.

Hanan EJ, Eigenbrot C, Bryan MC, Burdick DJ, Chan BK, Chen Y, Dotson J, Heald RA, Jackson PS, La H, Lainchbury MD, Malek S, Purkey HE, Schaefer G, Schmidt S, Seward EM, Sideris S, Tam C, Wang S, Yeap SK, Yen I, Yin J, Yu C, Zilberleyb I, Heffron TP.

J Med Chem. 2014 Dec 11;57(23):10176-91. doi: 10.1021/jm501578n. Epub 2014 Nov 20.

18.

Adjuvant therapy decisions based on magnetic resonance imaging of extramural venous invasion and other prognostic factors in colorectal cancer.

Chand M, Swift RI, Chau I, Heald RJ, Tekkis PP, Brown G.

Ann R Coll Surg Engl. 2014 Oct;96(7):543-6. doi: 10.1308/003588414X13814021678835.

PMID:
25245736
19.

The prognostic significance of postchemoradiotherapy high-resolution MRI and histopathology detected extramural venous invasion in rectal cancer.

Chand M, Evans J, Swift RI, Tekkis PP, West NP, Stamp G, Heald RJ, Brown G.

Ann Surg. 2015 Mar;261(3):473-9. doi: 10.1097/SLA.0000000000000848.

PMID:
25243543
20.

Total mesorectal excision optimized by pelvic MRI.

Chand M, Brown G, Tekkis P, Heald RJ.

Colorectal Dis. 2014 Nov;16(11):847-53. doi: 10.1111/codi.12773. Review. No abstract available.

PMID:
25204633
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