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Results: 1 to 20 of 229

1.

Therapeutic targeting of integrin αvβ6 in breast cancer.

Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR, Haider S, Brouilette K, Saha A, Vallath S, Bowen R, Chelala C, Eccles D, Tapper WJ, Thompson AM, Quinlan P, Jordan L, Gillett C, Brentnall A, Violette S, Weinreb PH, Kendrew J, Barry ST, Hart IR, Jones JL, Marshall JF.

J Natl Cancer Inst. 2014 Jun 28;106(8). pii: dju169. doi: 10.1093/jnci/dju169. Print 2014 Aug.

PMID:
24974129
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

RhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cells.

Li NF, Gemenetzidis E, Marshall FJ, Davies D, Yu Y, Frese K, Froeling FE, Woolf AK, Feakins RM, Naito Y, Iacobuzio-Donahue C, Tuveson DA, Hart IR, Kocher HM.

PLoS One. 2013 Dec 3;8(12):e81575. doi: 10.1371/journal.pone.0081575. eCollection 2013.

PMID:
24312560
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing.

Robbez-Masson LJ, Bödör C, Jones JL, Hurst HC, Fitzgibbon J, Hart IR, Grose RP.

PLoS One. 2013 Nov 12;8(11):e78839. doi: 10.1371/journal.pone.0078839. eCollection 2013.

PMID:
24265722
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence.

Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA, Dickinson S, Edwards DR, Pennington CJ, Sestak I, Cuzick J, Marshall JF, Hart IR, Jones JL.

Clin Cancer Res. 2014 Jan 15;20(2):344-57. doi: 10.1158/1078-0432.CCR-13-1504. Epub 2013 Oct 22.

PMID:
24150233
[PubMed - indexed for MEDLINE]
5.

FAK-heterozygous mice display enhanced tumour angiogenesis.

Kostourou V, Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR, Birdsey GM, Robinson SD, Parsons M, Randi AM, Hart IR, Hodivala-Dilke K.

Nat Commun. 2013;4:2020. doi: 10.1038/ncomms3020.

PMID:
23799510
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

Coughlan L, Vallath S, Gros A, Giménez-Alejandre M, Van Rooijen N, Thomas GJ, Baker AH, Cascalló M, Alemany R, Hart IR.

Hum Gene Ther. 2012 Sep;23(9):960-79. doi: 10.1089/hum.2011.218. Epub 2012 Aug 27.

PMID:
22708837
[PubMed - indexed for MEDLINE]
7.

β3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear.

Brunetta I, Casalotti SO, Hart IR, Forge A, Reynolds LE.

BMC Cell Biol. 2012 Mar 17;13:5. doi: 10.1186/1471-2121-13-5.

PMID:
22424110
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.

Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR, Garrod DR, Fortune F, Wan H.

J Pathol. 2012 May;227(1):81-93. doi: 10.1002/path.3982. Epub 2012 Feb 17.

PMID:
22294297
[PubMed - indexed for MEDLINE]
9.

Proteome of formalin-fixed paraffin-embedded pancreatic ductal adenocarcinoma and lymph node metastases.

Naidoo K, Jones R, Dmitrovic B, Wijesuriya N, Kocher H, Hart IR, Crnogorac-Jurcevic T.

J Pathol. 2012 Apr;226(5):756-63. doi: 10.1002/path.3959. Epub 2012 Jan 17. Erratum in: J Pathol. 2012 Aug;227(4):e8.

PMID:
22081483
[PubMed - indexed for MEDLINE]
10.

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression.

Froeling FE, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, Clevers H, Hart IR, Kocher HM.

Gastroenterology. 2011 Oct;141(4):1486-97, 1497.e1-14. doi: 10.1053/j.gastro.2011.06.047. Epub 2011 Jun 24.

PMID:
21704588
[PubMed - indexed for MEDLINE]
11.

A direct role for Met endocytosis in tumorigenesis.

Joffre C, Barrow R, Ménard L, Calleja V, Hart IR, Kermorgant S.

Nat Cell Biol. 2011 Jun 5;13(7):827-37. doi: 10.1038/ncb2257.

PMID:
21642981
[PubMed - indexed for MEDLINE]
12.

Editorial: Special section on "site-specific metastasis".

Allgayer H, Hart IR.

Int J Cancer. 2011 Jun 1;128(11):2509-10. doi: 10.1002/ijc.26050. No abstract available.

PMID:
21452336
[PubMed - indexed for MEDLINE]
13.

Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion.

Allen MD, Vaziri R, Green M, Chelala C, Brentnall AR, Dreger S, Vallath S, Nitch-Smith H, Hayward J, Carpenter R, Holliday DL, Walker RA, Hart IR, Jones JL.

J Pathol. 2011 Apr;223(5):646-58. doi: 10.1002/path.2833. Epub 2011 Feb 21.

PMID:
21341269
[PubMed - indexed for MEDLINE]
14.

Stromal features are predictive of disease mortality in oral cancer patients.

Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N, Violette SM, Weinreb PH, Chester KA, Chana JS, Marshall JF, Hart IR, Hackshaw AK, Piper K, Thomas GJ.

J Pathol. 2011 Mar;223(4):470-81. doi: 10.1002/path.2830. Epub 2011 Jan 5.

PMID:
21294121
[PubMed - indexed for MEDLINE]
15.

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF, Fortune F, Tilakaratne WM, Hart IR, Thomas GJ.

J Pathol. 2011 Feb;223(3):366-77. doi: 10.1002/path.2786. Epub 2010 Oct 25.

PMID:
21171082
[PubMed - indexed for MEDLINE]
16.

Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src.

Tsang SM, Liu L, Teh MT, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F, Wan H.

PLoS One. 2010 Dec 3;5(12):e14211. doi: 10.1371/journal.pone.0014211.

PMID:
21151980
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion.

Morgan MR, Jazayeri M, Ramsay AG, Thomas GJ, Boulanger MJ, Hart IR, Marshall JF.

Oncogene. 2011 Mar 24;30(12):1422-35. doi: 10.1038/onc.2010.535. Epub 2010 Dec 6.

PMID:
21132011
[PubMed - indexed for MEDLINE]
18.

Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.

da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, Iruela-Arispe ML, Dipersio CM, Kreidberg JA, Hodivala-Dilke KM.

Am J Pathol. 2010 Sep;177(3):1534-48. doi: 10.2353/ajpath.2010.100043. Epub 2010 Jul 16.

PMID:
20639457
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6.

Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR, Marshall JF.

J Pathol. 2010 Sep;222(1):52-63. doi: 10.1002/path.2745.

PMID:
20629113
[PubMed - indexed for MEDLINE]
20.

Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM.

Nature. 2010 Jun 10;465(7299):813-7. doi: 10.1038/nature09106. Erratum in: Nature. 2010 Jul 15;466(7304):398.

PMID:
20535211
[PubMed - indexed for MEDLINE]
Free PMC Article
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