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Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

Livesey MR, Magnani D, Hardingham GE, Chandran S, Wyllie DJ.

J Physiol. 2015 Nov 26. doi: 10.1113/JP270660. [Epub ahead of print]


Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.

Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, Scannevin RH, Chandran S, Hayes JD, Hardingham GE.

Nat Commun. 2015 May 13;6:7066. doi: 10.1038/ncomms8066.


Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system.

Baxter PS, Bell KF, Hasel P, Kaindl AM, Fricker M, Thomson D, Cregan SP, Gillingwater TH, Hardingham GE.

Nat Commun. 2015 Apr 9;6:6761. doi: 10.1038/ncomms7761.


Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons.

Hasel P, Mckay S, Qiu J, Hardingham GE.

Biochim Biophys Acta. 2015 Sep;1853(9):2066-76. doi: 10.1016/j.bbamcr.2014.12.021. Epub 2014 Dec 22.


Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.

James OT, Livesey MR, Qiu J, Dando O, Bilican B, Haghi G, Rajan R, Burr K, Hardingham GE, Chandran S, Kind PC, Wyllie DJ.

J Physiol. 2014 Oct 1;592(Pt 19):4353-63. doi: 10.1113/jphysiol.2014.278994. Epub 2014 Aug 28.


Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.

Deighton RF, Márkus NM, Al-Mubarak B, Bell KF, Papadia S, Meakin PJ, Chowdhry S, Hayes JD, Hardingham GE.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1818-20. doi: 10.1073/pnas.1402097111. Epub 2014 Apr 21. No abstract available.


Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons.

Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJ.

J Neurosci. 2014 Mar 12;34(11):4070-5. doi: 10.1523/JNEUROSCI.5410-13.2014.


Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells.

Bilican B, Livesey MR, Haghi G, Qiu J, Burr K, Siller R, Hardingham GE, Wyllie DJ, Chandran S.

PLoS One. 2014 Jan 17;9(1):e85932. doi: 10.1371/journal.pone.0085932. eCollection 2014.


Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy.

Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, Massie A, Hardingham GE, Maher P.

Antioxid Redox Signal. 2014 Jun 20;20(18):2907-22. doi: 10.1089/ars.2013.5455. Epub 2014 Feb 6.


Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.

Qiu J, Tan YW, Hagenston AM, Martel MA, Kneisel N, Skehel PA, Wyllie DJ, Bading H, Hardingham GE.

Nat Commun. 2013;4:2034. doi: 10.1038/ncomms3034.


Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S.

Sci Transl Med. 2013 Jun 5;5(188):188le2. doi: 10.1126/scitranslmed.3005065.


NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.

Gupta K, Hardingham GE, Chandran S.

Neurosci Lett. 2013 May 24;543:95-100. doi: 10.1016/j.neulet.2013.03.010. Epub 2013 Mar 18.


Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure.

McKay S, Bengtson CP, Bading H, Wyllie DJ, Hardingham GE.

Neuropharmacology. 2013 Nov;74:119-25. doi: 10.1016/j.neuropharm.2013.01.024. Epub 2013 Feb 10.


Influence of GluN2 subunit identity on NMDA receptor function.

Wyllie DJ, Livesey MR, Hardingham GE.

Neuropharmacology. 2013 Nov;74:4-17. doi: 10.1016/j.neuropharm.2013.01.016. Epub 2013 Jan 31. Review.


Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.

Gupta K, Chandran S, Hardingham GE.

Br J Clin Pharmacol. 2013 Apr;75(4):907-18. doi: 10.1111/bcp.12022. Review.


SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites.

Soriano FX, Chawla S, Skehel P, Hardingham GE.

J Neurochem. 2013 Jan;124(1):26-35. doi: 10.1111/jnc.12058. Epub 2012 Nov 15.


Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response.

Camacho A, Rodriguez-Cuenca S, Blount M, Prieur X, Barbarroja N, Fuller M, Hardingham GE, Vidal-Puig A.

Exp Neurol. 2012 Oct;237(2):396-406. doi: 10.1016/j.expneurol.2012.06.031. Epub 2012 Jul 6. Erratum in: Exp Neurol. 2013 Jan;239:101.


SynGAP isoforms exert opposing effects on synaptic strength.

McMahon AC, Barnett MW, O'Leary TS, Stoney PN, Collins MO, Papadia S, Choudhary JS, Komiyama NH, Grant SG, Hardingham GE, Wyllie DJ, Kind PC.

Nat Commun. 2012 Jun 12;3:900. doi: 10.1038/ncomms1900.


Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.

Patani R, Lewis PA, Trabzuni D, Puddifoot CA, Wyllie DJ, Walker R, Smith C, Hardingham GE, Weale M, Hardy J, Chandran S, Ryten M.

J Neurochem. 2012 Aug;122(4):738-51. doi: 10.1111/j.1471-4159.2012.07825.x. Epub 2012 Jul 10.


PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity.

Puddifoot C, Martel MA, Soriano FX, Camacho A, Vidal-Puig A, Wyllie DJ, Hardingham GE.

J Neurosci. 2012 May 16;32(20):6995-7000. doi: 10.1523/JNEUROSCI.6407-11.2012.

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