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Results: 1 to 20 of 94

1.

Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y14 Receptor Antagonist Molecular Probes.

Kiselev E, Barrett MO, Katritch V, Paoletta S, Weitzer CD, Brown KA, Hammes E, Yin AL, Zhao Q, Stevens RC, Harden TK, Jacobson KA.

ACS Chem Biol. 2014 Oct 20. [Epub ahead of print]

PMID:
25299434
[PubMed - as supplied by publisher]
2.

Membrane-induced allosteric control of phospholipase C-β isozymes.

Charpentier TH, Waldo GL, Barrett MO, Huang W, Zhang Q, Harden TK, Sondek J.

J Biol Chem. 2014 Oct 24;289(43):29545-57. doi: 10.1074/jbc.M114.586784. Epub 2014 Sep 5.

PMID:
25193662
[PubMed - in process]
3.

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.

Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.

PMID:
25036778
[PubMed - in process]
4.

Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand.

Song L, Risseeuw MD, Karalic I, Barrett MO, Brown KA, Harden TK, Van Calenbergh S.

Molecules. 2014 Apr 4;19(4):4313-25. doi: 10.3390/molecules19044313.

PMID:
24714193
[PubMed - indexed for MEDLINE]
Free Article
5.

4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.

Jayasekara PS, Barrett MO, Ball CB, Brown KA, Hammes E, Balasubramanian R, Harden TK, Jacobson KA.

J Med Chem. 2014 May 8;57(9):3874-83. doi: 10.1021/jm500367e. Epub 2014 Apr 18.

PMID:
24712832
[PubMed - indexed for MEDLINE]
6.

Enigmatic GPCR finds a stimulating drug.

Harden TK.

Sci Signal. 2013 Oct 22;6(298):pe34. doi: 10.1126/scisignal.2004755.

PMID:
24150253
[PubMed - indexed for MEDLINE]
7.

Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17.

Qi AD, Harden TK, Nicholas RA.

J Pharmacol Exp Ther. 2013 Oct;347(1):38-46. doi: 10.1124/jpet.113.207647. Epub 2013 Aug 1.

PMID:
23908386
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes.

Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek J.

Biochemistry. 2013 Jul 16;52(28):4810-9. doi: 10.1021/bi400433b. Epub 2013 Jul 9.

PMID:
23777354
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

Barrett MO, Sesma JI, Ball CB, Jayasekara PS, Jacobson KA, Lazarowski ER, Harden TK.

Mol Pharmacol. 2013 Jul;84(1):41-9. doi: 10.1124/mol.113.085654. Epub 2013 Apr 16.

PMID:
23592514
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Small molecule inhibitors of phospholipase C from a novel high-throughput screen.

Huang W, Barrett M, Hajicek N, Hicks S, Harden TK, Sondek J, Zhang Q.

J Biol Chem. 2013 Feb 22;288(8):5840-8. doi: 10.1074/jbc.M112.422501. Epub 2013 Jan 7.

PMID:
23297405
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.

PMID:
23211529
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C.

Wang X, Barrett M, Sondek J, Harden TK, Zhang Q.

Biochemistry. 2012 Jul 3;51(26):5300-6. Epub 2012 Jun 22.

PMID:
22703043
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.

Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER.

Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C490-8. doi: 10.1152/ajpcell.00138.2012. Epub 2012 Jun 6.

PMID:
22673622
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The phospholipase C isozymes and their regulation.

Gresset A, Sondek J, Harden TK.

Subcell Biochem. 2012;58:61-94. doi: 10.1007/978-94-007-3012-0_3. Review.

PMID:
22403074
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.

Tang W, Zhang Y, Xu W, Harden TK, Sondek J, Sun L, Li L, Wu D.

Dev Cell. 2011 Dec 13;21(6):1038-50. doi: 10.1016/j.devcel.2011.10.023.

PMID:
22172670
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes.

Harden TK, Waldo GL, Hicks SN, Sondek J.

Chem Rev. 2011 Oct 12;111(10):6120-9. doi: 10.1021/cr200209p. No abstract available.

PMID:
21988240
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Acireductone dioxygenase 1 (ARD1) is an effector of the heterotrimeric G protein beta subunit in Arabidopsis.

Friedman EJ, Wang HX, Jiang K, Perovic I, Deshpande A, Pochapsky TC, Temple BR, Hicks SN, Harden TK, Jones AM.

J Biol Chem. 2011 Aug 26;286(34):30107-18. doi: 10.1074/jbc.M111.227256. Epub 2011 Jun 28.

PMID:
21712381
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Molecular pharmacology, physiology, and structure of the P2Y receptors.

von Kügelgen I, Harden TK.

Adv Pharmacol. 2011;61:373-415. doi: 10.1016/B978-0-12-385526-8.00012-6. Review.

PMID:
21586365
[PubMed - indexed for MEDLINE]
19.

Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.

Maruoka H, Jayasekara MP, Barrett MO, Franklin DA, de Castro S, Kim N, Costanzi S, Harden TK, Jacobson KA.

J Med Chem. 2011 Jun 23;54(12):4018-33. doi: 10.1021/jm101591j. Epub 2011 May 20.

PMID:
21528910
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cells.

Qi AD, Houston-Cohen D, Naruszewicz I, Harden TK, Nicholas RA.

Br J Pharmacol. 2011 Mar;162(6):1304-13. doi: 10.1111/j.1476-5381.2010.01135.x.

PMID:
21108629
[PubMed - indexed for MEDLINE]
Free PMC Article

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