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Results: 1 to 20 of 407

1.

Effect of hydrophobic scaffold on the cellular uptake and gene transfection activities of DNA-encapsulating liposomal nanoparticles via intracerebroventricular administration.

Akita H, Nakatani T, Kuroki K, Maenaka K, Tange K, Nakai Y, Harashima H.

Int J Pharm. 2015 May 20. pii: S0378-5173(15)00462-7. doi: 10.1016/j.ijpharm.2015.05.043. [Epub ahead of print]

PMID:
26003418
2.

General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation.

Sakai-Kato K, Nishiyama N, Kozaki M, Nakanishi T, Matsuda Y, Hirano M, Hanada H, Hisada S, Onodera H, Harashima H, Matsumura Y, Kataoka K, Goda Y, Okuda H, Kawanishi T.

J Control Release. 2015 May 13;210:76-83. doi: 10.1016/j.jconrel.2015.05.259. [Epub ahead of print] Review.

PMID:
25979322
3.

FoxO6 Depletion Attenuates Hepatic Gluconeogenesis and Protects Against Fat-Induced Glucose Disorder in Mice.

Calabuig-Navarro V, Yamauchi J, Lee S, Zhang T, Liu YZ, Sadlek K, Coudriet GM, Piganelli JD, Jiang CL, Miller R, Lowe M, Harashima H, Dong HH.

J Biol Chem. 2015 May 5. pii: jbc.M115.650994. [Epub ahead of print]

4.

A multifunctional envelope-type nano device: Evolution from non-selective to active targeting system.

Harashima H, Hayashi Y, Hatakeyama H, Kajimoto K, Hyodo M, Akita H.

Bioconjug Chem. 2015 May 4. [Epub ahead of print]

PMID:
25938819
5.

Mitochondrial delivery of antisense RNA by MITO-Porter results in mitochondrial RNA knockdown, and has a functional impact on mitochondria.

Furukawa R, Yamada Y, Kawamura E, Harashima H.

Biomaterials. 2015 Jul;57:107-15. doi: 10.1016/j.biomaterials.2015.04.022. Epub 2015 Apr 24.

PMID:
25913255
6.

Hyaluronic acid controls the uptake pathway and intracellular trafficking of an octaarginine-modified gene vector in CD44 positive- and CD44 negative-cells.

Yamada Y, Hashida M, Harashima H.

Biomaterials. 2015 Jun;52:189-98. doi: 10.1016/j.biomaterials.2015.02.027. Epub 2015 Feb 25.

PMID:
25818425
7.

Action-at-a-Distance Mutagenesis Induced by Oxidized Guanine in Werner Syndrome Protein-Reduced Human Cells.

Kamiya H, Yamazaki D, Nakamura E, Makino T, Kobayashi M, Matsuoka I, Harashima H.

Chem Res Toxicol. 2015 Apr 20;28(4):621-8. doi: 10.1021/tx500418m. Epub 2015 Mar 2.

PMID:
25730140
8.

Targeting the mitochondrial genome via a dual function MITO-Porter: evaluation of mtDNA levels and mitochondrial function.

Yamada Y, Harashima H.

Methods Mol Biol. 2015;1265:123-33. doi: 10.1007/978-1-4939-2288-8_10.

PMID:
25634272
9.

A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant.

Miura N, Shaheen SM, Akita H, Nakamura T, Harashima H.

Nucleic Acids Res. 2015 Feb 18;43(3):1317-31. doi: 10.1093/nar/gkv008. Epub 2015 Jan 20.

10.

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus.

Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice CM, Harashima H, Kohara M, Tanaka Y, Takaoka A.

Immunity. 2015 Jan 20;42(1):123-32. doi: 10.1016/j.immuni.2014.12.016. Epub 2014 Dec 18.

PMID:
25557055
11.

Efficient and High-Speed Transduction of an Antibody into Living Cells Using a Multifunctional Nanocarrier System to Control Intracellular Trafficking.

Yamada Y, Perez SM, Tabata M, Abe J, Yasuzaki Y, Harashima H.

J Pharm Sci. 2014 Dec 26. doi: 10.1002/jps.24310. [Epub ahead of print]

PMID:
25546552
12.

A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma.

Akita H, Ishiba R, Togashi R, Tange K, Nakai Y, Hatakeyama H, Harashima H.

J Control Release. 2015 Feb 28;200:97-105. doi: 10.1016/j.jconrel.2014.12.029. Epub 2014 Dec 24.

PMID:
25543000
13.
14.

Multifunctional enveloped nanodevices (MENDs).

Sato Y, Nakamura T, Yamada Y, Akita H, Harashima H.

Adv Genet. 2014;88:139-204. doi: 10.1016/B978-0-12-800148-6.00006-7.

PMID:
25409606
15.

Advances in an active and passive targeting to tumor and adipose tissues.

Sakurai Y, Kajimoto K, Hatakeyama H, Harashima H.

Expert Opin Drug Deliv. 2015 Jan;12(1):41-52. doi: 10.1517/17425247.2015.955847. Epub 2014 Nov 7.

PMID:
25376864
16.

Construction of an aptamer modified liposomal system targeted to tumor endothelial cells.

Ara MN, Matsuda T, Hyodo M, Sakurai Y, Ohga N, Hida K, Harashima H.

Biol Pharm Bull. 2014;37(11):1742-9.

17.

New MT-ND6 and NDUFA1 mutations in mitochondrial respiratory chain disorders.

Uehara N, Mori M, Tokuzawa Y, Mizuno Y, Tamaru S, Kohda M, Moriyama Y, Nakachi Y, Matoba N, Sakai T, Yamazaki T, Harashima H, Murayama K, Hattori K, Hayashi J, Yamagata T, Fujita Y, Ito M, Tanaka M, Nibu K, Ohtake A, Okazaki Y.

Ann Clin Transl Neurol. 2014 May;1(5):361-9. doi: 10.1002/acn3.59. Epub 2014 Apr 28.

18.

Mechanism responsible for the antitumor effect of BCG-CWS using the LEEL method in a mouse bladder cancer model.

Nakamura T, Fukiage M, Suzuki Y, Yano I, Miyazaki J, Nishiyama H, Akaza H, Harashima H.

J Control Release. 2014 Dec 28;196:161-7. doi: 10.1016/j.jconrel.2014.10.007. Epub 2014 Oct 12.

PMID:
25315488
19.

The screening of RNA aptamers specific for carbonic anhydrase I using the Systematic Evolution of Ligands by an Exponential Enrichment Method (SELEX).

Shrivastava G, Hyodo M, Ara MN, Harashima H.

Nucleosides Nucleotides Nucleic Acids. 2014;33(11):697-708. doi: 10.1080/15257770.2014.931587.

PMID:
25295747
20.

Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain.

Tamaru M, Akita H, Nakatani T, Kajimoto K, Sato Y, Hatakeyama H, Harashima H.

Int J Nanomedicine. 2014 Sep 8;9:4267-76. doi: 10.2147/IJN.S65402. eCollection 2014.

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