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Items: 1 to 20 of 125


Protein Targets of Isoniazid-Reactive Metabolites in Mouse Liver in Vivo.

Koen YM, Galeva NA, Metushi IG, Uetrecht J, Hanzlik RP.

Chem Res Toxicol. 2016 Jun 20;29(6):1064-72. doi: 10.1021/acs.chemrestox.6b00098. Epub 2016 May 5.


Branched amphiphilic peptide capsules: cellular uptake and retention of encapsulated solutes.

Sukthankar P, Avila LA, Whitaker SK, Iwamoto T, Morgenstern A, Apostolidis C, Liu K, Hanzlik RP, Dadachova E, Tomich JM.

Biochim Biophys Acta. 2014 Sep;1838(9):2296-305. doi: 10.1016/j.bbamem.2014.02.005. Epub 2014 Feb 22.


Bioinformatic analysis of 302 reactive metabolite target proteins. Which ones are important for cell death?

Hanzlik RP, Koen YM, Fang J.

Toxicol Sci. 2013 Oct;135(2):390-401. doi: 10.1093/toxsci/kft166. Epub 2013 Jul 28.


Protein targets of thioacetamide metabolites in rat hepatocytes.

Koen YM, Sarma D, Hajovsky H, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2013 Apr 15;26(4):564-74. doi: 10.1021/tx400001x. Epub 2013 Mar 20.


Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes.

Hajovsky H, Hu G, Koen Y, Sarma D, Cui W, Moore DS, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Sep 17;25(9):1955-63. doi: 10.1021/tx3002719. Epub 2012 Aug 17.


Liver protein targets of hepatotoxic 4-bromophenol metabolites.

Koen YM, Hajovsky H, Liu K, Williams TD, Galeva NA, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Aug 20;25(8):1777-86. doi: 10.1021/tx3002675. Epub 2012 Aug 3.


Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.

Sarma D, Hajovsky H, Koen YM, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP.

Chem Res Toxicol. 2012 Sep 17;25(9):1868-77. doi: 10.1021/tx3001658. Epub 2012 Jun 15.


Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes.

Koen YM, Sarma D, Williams TD, Galeva NA, Obach RS, Hanzlik RP.

Chem Res Toxicol. 2012 May 21;25(5):1145-54. doi: 10.1021/tx300103j. Epub 2012 Apr 10.


Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1.


Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.

Fang J, Koen YM, Hanzlik RP.

BMC Chem Biol. 2009 Jun 12;9:5. doi: 10.1186/1472-6769-9-5.


Ocular and systemic safety evaluation of calcium formate as a dietary supplement.

Altaweel MM, Hanzlik RP, Ver Hoeve JN, Eells J, Zhang B.

J Ocul Pharmacol Ther. 2009 Jun;25(3):223-30. doi: 10.1089/jop.2008.0128.


Eulogy to Mathias P. Mertes, 1932-1989.

Bowman-James K, Grunewald GL, Hanzlik RP.

Med Res Rev. 2009 Jan;29(1):1-2. doi: 10.1002/med.20147. No abstract available.


Filling and mining the reactive metabolite target protein database.

Hanzlik RP, Fang J, Koen YM.

Chem Biol Interact. 2009 Apr 15;179(1):38-44. doi: 10.1016/j.cbi.2008.08.016. Epub 2008 Sep 6. Review.


Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo.

Ikehata K, Duzhak TG, Galeva NA, Ji T, Koen YM, Hanzlik RP.

Chem Res Toxicol. 2008 Jul;21(7):1432-42. doi: 10.1021/tx800093k. Epub 2008 Jun 12.


X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives.

Huang W, Yamamoto Y, Li Y, Dou D, Alliston KR, Hanzlik RP, Williams TD, Groutas WC.

J Med Chem. 2008 Apr 10;51(7):2003-8. doi: 10.1021/jm700966p. Epub 2008 Mar 5.


Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.

Ji T, Ikehata K, Koen YM, Esch SW, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2007 Apr;20(4):701-8. Epub 2007 Mar 24.


The reactive metabolite target protein database (TPDB)--a web-accessible resource.

Hanzlik RP, Koen YM, Theertham B, Dong Y, Fang J.

BMC Bioinformatics. 2007 Mar 16;8:95.


A proteomic analysis of bromobenzene reactive metabolite targets in rat liver cytosol in vivo.

Koen YM, Gogichaeva NV, Alterman MA, Hanzlik RP.

Chem Res Toxicol. 2007 Mar;20(3):511-9. Epub 2007 Feb 17.


Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo.

Koen YM, Yue W, Galeva NA, Williams TD, Hanzlik RP.

Chem Res Toxicol. 2006 Nov;19(11):1426-34.

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