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Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism.

Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL.

J Biol Chem. 2015 Sep 25;290(39):23751-65. doi: 10.1074/jbc.M115.643544. Epub 2015 Aug 5.


Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.

Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL.

Skelet Muscle. 2015 Jan 29;5:4. doi: 10.1186/s13395-014-0027-1. eCollection 2015.


Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.

Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL.

J Biol Chem. 2014 Sep 12;289(37):25556-70. doi: 10.1074/jbc.M114.586289. Epub 2014 Jul 22.


Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin.

Knoblauch M, Dagnino-Acosta A, Hamilton SL.

Skelet Muscle. 2013 Sep 3;3(1):22. doi: 10.1186/2044-5040-3-22.


AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.

Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL.

Nat Med. 2012 Jan 8;18(2):244-51. doi: 10.1038/nm.2598.


Ryanodine receptors: structure, expression, molecular details, and function in calcium release.

Lanner JT, Georgiou DK, Joshi AD, Hamilton SL.

Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a003996. doi: 10.1101/cshperspect.a003996. Epub 2010 Oct 20. Review.


Determinants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin.

Halling DB, Georgiou DK, Black DJ, Yang G, Fallon JL, Quiocho FA, Pedersen SE, Hamilton SL.

J Biol Chem. 2009 Jul 24;284(30):20041-51. doi: 10.1074/jbc.M109.013326. Epub 2009 May 27.


Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins.

Fallon JL, Baker MR, Xiong L, Loy RE, Yang G, Dirksen RT, Hamilton SL, Quiocho FA.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5135-40. doi: 10.1073/pnas.0807487106. Epub 2009 Mar 11.


Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior.

Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E.

Neuron. 2008 Dec 10;60(5):832-45. doi: 10.1016/j.neuron.2008.09.037.


Ryanodine receptor structure: progress and challenges.

Hamilton SL, Serysheva II.

J Biol Chem. 2009 Feb 13;284(7):4047-51. doi: 10.1074/jbc.R800054200. Epub 2008 Oct 16. Review. No abstract available.


Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel.

Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9610-5. doi: 10.1073/pnas.0803189105. Epub 2008 Jul 10.


RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice.

Durham WJ, Aracena-Parks P, Long C, Rossi AE, Goonasekera SA, Boncompagni S, Galvan DL, Gilman CP, Baker MR, Shirokova N, Protasi F, Dirksen R, Hamilton SL.

Cell. 2008 Apr 4;133(1):53-65. doi: 10.1016/j.cell.2008.02.042.


Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK.

Huddleston AT, Tang W, Takeshima H, Hamilton SL, Klann E.

J Neurophysiol. 2008 Mar;99(3):1565-71. doi: 10.1152/jn.00659.2007. Epub 2008 Jan 16.


Diseases associated with altered ryanodine receptor activity.

Durham WJ, Wehrens XH, Sood S, Hamilton SL.

Subcell Biochem. 2007;45:273-321. Review.


FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure.

Long C, Cook LG, Hamilton SL, Wu GY, Mitchell BM.

Hypertension. 2007 Mar;49(3):569-76. Epub 2007 Jan 29.


Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1.

Aracena-Parks P, Goonasekera SA, Gilman CP, Dirksen RT, Hidalgo C, Hamilton SL.

J Biol Chem. 2006 Dec 29;281(52):40354-68. Epub 2006 Oct 27.


Regulation of voltage-gated Ca2+ channels by calmodulin.

Halling DB, Aracena-Parks P, Hamilton SL.

Sci STKE. 2006 Jan 17;2006(318):er1. Review.


Regulation of voltage-gated Ca2+ channels by calmodulin.

Halling DB, Aracena-Parks P, Hamilton SL.

Sci STKE. 2005 Dec 20;2005(315):re15. Review. Corrected and republished in: Sci STKE. 2006 Jan 17;2006(318):er1.


Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel.

Fallon JL, Halling DB, Hamilton SL, Quiocho FA.

Structure. 2005 Dec;13(12):1881-6.


Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse.

Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL.

FASEB J. 2006 Feb;20(2):329-30. Epub 2005 Nov 11.

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