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Items: 1 to 20 of 22


Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.

Hamacher-Brady A, Brady NR.

Cell Mol Life Sci. 2015 Nov 26. [Epub ahead of print]


Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis.

Choe SC, Hamacher-Brady A, Brady NR.

Cell Commun Signal. 2015 Aug 8;13:37. doi: 10.1186/s12964-015-0115-9.


Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells.

Eling N, Reuter L, Hazin J, Hamacher-Brady A, Brady NR.

Oncoscience. 2015 May 2;2(5):517-32. eCollection 2015.


Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62.

Metz P, Chiramel A, Chatel-Chaix L, Alvisi G, Bankhead P, Mora-Rodriguez R, Long G, Hamacher-Brady A, Brady NR, Bartenschlager R.

J Virol. 2015 Aug;89(15):8026-41.


Agent-based modeling of autophagy reveals emergent regulatory behavior of spatio-temporal autophagy dynamics.

Börlin CS, Lang V, Hamacher-Brady A, Brady NR.

Cell Commun Signal. 2014 Sep 10;12:56. doi: 10.1186/s12964-014-0056-8.


Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase.

Hamacher-Brady A, Choe SC, Krijnse-Locker J, Brady NR.

Cell Death Differ. 2014 Dec;21(12):1862-76. doi: 10.1038/cdd.2014.101. Epub 2014 Aug 1.


Histone deacetylase 10 promotes autophagy-mediated cell survival.

Oehme I, Linke JP, Böck BC, Milde T, Lodrini M, Hartenstein B, Wiegand I, Eckert C, Roth W, Kool M, Kaden S, Gröne HJ, Schulte JH, Lindner S, Hamacher-Brady A, Brady NR, Deubzer HE, Witt O.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2592-601. doi: 10.1073/pnas.1300113110. Epub 2013 Jun 25.


Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis.

Zhu Y, Massen S, Terenzio M, Lang V, Chen-Lindner S, Eils R, Novak I, Dikic I, Hamacher-Brady A, Brady NR.

J Biol Chem. 2013 Jan 11;288(2):1099-113. doi: 10.1074/jbc.M112.399345. Epub 2012 Dec 3.


Antagonistic regulation of apoptosis and differentiation by the Cut transcription factor represents a tumor-suppressing mechanism in Drosophila.

Zhai Z, Ha N, Papagiannouli F, Hamacher-Brady A, Brady N, Sorge S, Bezdan D, Lohmann I.

PLoS Genet. 2012;8(3):e1002582. doi: 10.1371/journal.pgen.1002582. Epub 2012 Mar 15.


Multi-parametric analysis and modeling of relationships between mitochondrial morphology and apoptosis.

Reis Y, Bernardo-Faura M, Richter D, Wolf T, Brors B, Hamacher-Brady A, Eils R, Brady NR.

PLoS One. 2012;7(1):e28694. doi: 10.1371/journal.pone.0028694. Epub 2012 Jan 17.


Autophagy regulation and integration with cell signaling.

Hamacher-Brady A.

Antioxid Redox Signal. 2012 Sep 1;17(5):756-65. doi: 10.1089/ars.2011.4410. Epub 2012 Jan 25. Review.


Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy.

Hundeshagen P, Hamacher-Brady A, Eils R, Brady NR.

BMC Biol. 2011 Jun 2;9:38. doi: 10.1186/1741-7007-9-38.


Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production.

Hamacher-Brady A, Stein HA, Turschner S, Toegel I, Mora R, Jennewein N, Efferth T, Eils R, Brady NR.

J Biol Chem. 2011 Feb 25;286(8):6587-601. doi: 10.1074/jbc.M110.210047. Epub 2010 Dec 13.


Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole.

Huang C, Liu W, Perry CN, Yitzhaki S, Lee Y, Yuan H, Tsukada YT, Hamacher-Brady A, Mentzer RM Jr, Gottlieb RA.

Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H570-9. doi: 10.1152/ajpheart.00716.2009. Epub 2009 Dec 11.


The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy.

Hamacher-Brady A, Brady NR, Gottlieb RA.

Cardiovasc Drugs Ther. 2006 Dec;20(6):445-62. Review.


A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria.

Brady NR, Hamacher-Brady A, Westerhoff HV, Gottlieb RA.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1651-65. Review.


Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes.

Hamacher-Brady A, Brady NR, Gottlieb RA.

J Biol Chem. 2006 Oct 6;281(40):29776-87. Epub 2006 Aug 1.


Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heart.

Hamacher-Brady A, Brady NR, Gottlieb RA, Gustafsson AB.

Autophagy. 2006 Oct-Dec;2(4):307-9. Epub 2006 Oct 25.

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