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RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.

Patel J, McNeill E, Douglas G, Hale AB, de Bono J, Lee R, Iqbal AJ, Regan-Komito D, Stylianou E, Greaves DR, Channon KM.

Nat Commun. 2015 Mar 18;6:6614. doi: 10.1038/ncomms7614.


CXCR2 modulates bone marrow vascular repair and haematopoietic recovery post-transplant.

Hale SJ, Hale AB, Zhang Y, Sweeney D, Fisher N, van der Garde M, Grabowska R, Pepperell E, Channon K, Martin-Rendon E, Watt SM.

Br J Haematol. 2015 May;169(4):552-64. doi: 10.1111/bjh.13335. Epub 2015 Mar 9.


A requirement for Gch1 and tetrahydrobiopterin in embryonic development.

Douglas G, Hale AB, Crabtree MJ, Ryan BJ, Hansler A, Watschinger K, Gross SS, Lygate CA, Alp NJ, Channon KM.

Dev Biol. 2015 Mar 1;399(1):129-38. doi: 10.1016/j.ydbio.2014.12.025. Epub 2014 Dec 31.


Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.

McNeill E, Crabtree MJ, Sahgal N, Patel J, Chuaiphichai S, Iqbal AJ, Hale AB, Greaves DR, Channon KM.

Free Radic Biol Med. 2015 Feb;79:206-16. doi: 10.1016/j.freeradbiomed.2014.10.575. Epub 2014 Nov 6.


Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection.

Fan LM, Douglas G, Bendall JK, McNeill E, Crabtree MJ, Hale AB, Mai A, Li JM, McAteer MA, Schneider JE, Choudhury RP, Channon KM.

Circulation. 2014 Jun 24;129(25):2661-72. doi: 10.1161/CIRCULATIONAHA.113.005062. Epub 2014 May 7.


Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

Chuaiphichai S, McNeill E, Douglas G, Crabtree MJ, Bendall JK, Hale AB, Alp NJ, Channon KM.

Hypertension. 2014 Sep;64(3):530-40. doi: 10.1161/HYPERTENSIONAHA.114.03089. Epub 2014 Apr 28.


α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.

Ryan BJ, Lourenço-Venda LL, Crabtree MJ, Hale AB, Channon KM, Wade-Martins R.

Free Radic Biol Med. 2014 Feb;67:58-68. doi: 10.1016/j.freeradbiomed.2013.10.008. Epub 2013 Oct 19.


Chronic estrogen deficiency causes gastroparesis by altering neuronal nitric oxide synthase function.

Ravella K, Al-Hendy A, Sharan C, Hale AB, Channon KM, Srinivasan S, Gangula PR.

Dig Dis Sci. 2013 Jun;58(6):1507-15. doi: 10.1007/s10620-013-2610-4. Epub 2013 Mar 17.


Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.

Crabtree MJ, Brixey R, Batchelor H, Hale AB, Channon KM.

J Biol Chem. 2013 Jan 4;288(1):561-9. doi: 10.1074/jbc.M112.415992. Epub 2012 Nov 8.


Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification.

Douglas G, Van Kampen E, Hale AB, McNeill E, Patel J, Crabtree MJ, Ali Z, Hoerr RA, Alp NJ, Channon KM.

Eur Heart J. 2013 Nov;34(43):3378-88. doi: 10.1093/eurheartj/ehs240. Epub 2012 Sep 24.


Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.

Carnicer R, Hale AB, Suffredini S, Liu X, Reilly S, Zhang MH, Surdo NC, Bendall JK, Crabtree MJ, Lim GB, Alp NJ, Channon KM, Casadei B.

Circ Res. 2012 Aug 31;111(6):718-27. doi: 10.1161/CIRCRESAHA.112.274464. Epub 2012 Jul 12.


Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.

Douglas G, Bendall JK, Crabtree MJ, Tatham AL, Carter EE, Hale AB, Channon KM.

Cardiovasc Res. 2012 Apr 1;94(1):20-9. doi: 10.1093/cvr/cvs026. Epub 2012 Jan 27.


Loss of NRF2 impairs gastric nitrergic stimulation and function.

Mukhopadhyay S, Sekhar KR, Hale AB, Channon KM, Farrugia G, Freeman ML, Gangula PR.

Free Radic Biol Med. 2011 Aug 1;51(3):619-25. doi: 10.1016/j.freeradbiomed.2011.04.044. Epub 2011 May 4.


Impairment of nitrergic system and delayed gastric emptying in low density lipoprotein receptor deficient female mice.

Gangula PR, Chinnathambi V, Hale AB, Mukhopadhyay S, Channon KM, Ravella K.

Neurogastroenterol Motil. 2011 Aug;23(8):773-e335. doi: 10.1111/j.1365-2982.2011.01695.x. Epub 2011 Mar 18.


Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.

Crabtree MJ, Hale AB, Channon KM.

Free Radic Biol Med. 2011 Jun 1;50(11):1639-46. doi: 10.1016/j.freeradbiomed.2011.03.010. Epub 2011 Mar 12.


Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.

Schmidt TS, McNeill E, Douglas G, Crabtree MJ, Hale AB, Khoo J, O'Neill CA, Cheng A, Channon KM, Alp NJ.

Clin Sci (Lond). 2010 May 6;119(3):131-42. doi: 10.1042/CS20090559.


Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.

Moens AL, Leyton-Mange JS, Niu X, Yang R, Cingolani O, Arkenbout EK, Champion HC, Bedja D, Gabrielson KL, Chen J, Xia Y, Hale AB, Channon KM, Halushka MK, Barker N, Wuyts FL, Kaminski PM, Wolin MS, Kass DA, Barouch LA.

J Mol Cell Cardiol. 2009 Nov;47(5):576-85. doi: 10.1016/j.yjmcc.2009.06.005. Epub 2009 Sep 18.


Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.

Crabtree MJ, Tatham AL, Al-Wakeel Y, Warrick N, Hale AB, Cai S, Channon KM, Alp NJ.

J Biol Chem. 2009 Jan 9;284(2):1136-44. doi: 10.1074/jbc.M805403200. Epub 2008 Nov 14.


Genetic and functional association of FAM5C with myocardial infarction.

Connelly JJ, Shah SH, Doss JF, Gadson S, Nelson S, Crosslin DR, Hale AB, Lou X, Wang T, Haynes C, Seo D, Crossman DC, Mooser V, Granger CB, Jones CJ, Kraus WE, Hauser ER, Gregory SG.

BMC Med Genet. 2008 Apr 22;9:33. doi: 10.1186/1471-2350-9-33.

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