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Results: 1 to 20 of 23

1.

Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection.

Fan LM, Douglas G, Bendall JK, McNeill E, Crabtree MJ, Hale AB, Mai A, Li JM, McAteer MA, Schneider JE, Choudhury RP, Channon KM.

Circulation. 2014 Jun 24;129(25):2661-72. doi: 10.1161/CIRCULATIONAHA.113.005062. Epub 2014 May 7.

PMID:
24807872
[PubMed - indexed for MEDLINE]
2.

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

Chuaiphichai S, McNeill E, Douglas G, Crabtree MJ, Bendall JK, Hale AB, Alp NJ, Channon KM.

Hypertension. 2014 Sep;64(3):530-40. doi: 10.1161/HYPERTENSIONAHA.114.03089. Epub 2014 Apr 28.

PMID:
24777984
[PubMed - in process]
3.

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.

Ryan BJ, Lourenço-Venda LL, Crabtree MJ, Hale AB, Channon KM, Wade-Martins R.

Free Radic Biol Med. 2014 Feb;67:58-68. doi: 10.1016/j.freeradbiomed.2013.10.008. Epub 2013 Oct 19.

PMID:
24148766
[PubMed - in process]
4.

Chronic estrogen deficiency causes gastroparesis by altering neuronal nitric oxide synthase function.

Ravella K, Al-Hendy A, Sharan C, Hale AB, Channon KM, Srinivasan S, Gangula PR.

Dig Dis Sci. 2013 Jun;58(6):1507-15. doi: 10.1007/s10620-013-2610-4. Epub 2013 Mar 17.

PMID:
23504347
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.

Crabtree MJ, Brixey R, Batchelor H, Hale AB, Channon KM.

J Biol Chem. 2013 Jan 4;288(1):561-9. doi: 10.1074/jbc.M112.415992. Epub 2012 Nov 8.

PMID:
23139420
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification.

Douglas G, Van Kampen E, Hale AB, McNeill E, Patel J, Crabtree MJ, Ali Z, Hoerr RA, Alp NJ, Channon KM.

Eur Heart J. 2013 Nov;34(43):3378-88. doi: 10.1093/eurheartj/ehs240. Epub 2012 Sep 24.

PMID:
23008511
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.

Carnicer R, Hale AB, Suffredini S, Liu X, Reilly S, Zhang MH, Surdo NC, Bendall JK, Crabtree MJ, Lim GB, Alp NJ, Channon KM, Casadei B.

Circ Res. 2012 Aug 31;111(6):718-27. doi: 10.1161/CIRCRESAHA.112.274464. Epub 2012 Jul 12.

PMID:
22798524
[PubMed - indexed for MEDLINE]
Free Article
8.

Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.

Douglas G, Bendall JK, Crabtree MJ, Tatham AL, Carter EE, Hale AB, Channon KM.

Cardiovasc Res. 2012 Apr 1;94(1):20-9. doi: 10.1093/cvr/cvs026. Epub 2012 Jan 27.

PMID:
22287576
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Loss of NRF2 impairs gastric nitrergic stimulation and function.

Mukhopadhyay S, Sekhar KR, Hale AB, Channon KM, Farrugia G, Freeman ML, Gangula PR.

Free Radic Biol Med. 2011 Aug 1;51(3):619-25. doi: 10.1016/j.freeradbiomed.2011.04.044. Epub 2011 May 4.

PMID:
21605664
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Impairment of nitrergic system and delayed gastric emptying in low density lipoprotein receptor deficient female mice.

Gangula PR, Chinnathambi V, Hale AB, Mukhopadhyay S, Channon KM, Ravella K.

Neurogastroenterol Motil. 2011 Aug;23(8):773-e335. doi: 10.1111/j.1365-2982.2011.01695.x. Epub 2011 Mar 18.

PMID:
21414103
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.

Crabtree MJ, Hale AB, Channon KM.

Free Radic Biol Med. 2011 Jun 1;50(11):1639-46. doi: 10.1016/j.freeradbiomed.2011.03.010. Epub 2011 Mar 12.

PMID:
21402147
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.

Schmidt TS, McNeill E, Douglas G, Crabtree MJ, Hale AB, Khoo J, O'Neill CA, Cheng A, Channon KM, Alp NJ.

Clin Sci (Lond). 2010 May 6;119(3):131-42. doi: 10.1042/CS20090559.

PMID:
20337596
[PubMed - indexed for MEDLINE]
Free Article
13.

Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.

Moens AL, Leyton-Mange JS, Niu X, Yang R, Cingolani O, Arkenbout EK, Champion HC, Bedja D, Gabrielson KL, Chen J, Xia Y, Hale AB, Channon KM, Halushka MK, Barker N, Wuyts FL, Kaminski PM, Wolin MS, Kass DA, Barouch LA.

J Mol Cell Cardiol. 2009 Nov;47(5):576-85. doi: 10.1016/j.yjmcc.2009.06.005. Epub 2009 Sep 18.

PMID:
19766235
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.

Crabtree MJ, Tatham AL, Hale AB, Alp NJ, Channon KM.

J Biol Chem. 2009 Oct 9;284(41):28128-36. doi: 10.1074/jbc.M109.041483. Epub 2009 Aug 7.

PMID:
19666465
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.

Crabtree MJ, Tatham AL, Al-Wakeel Y, Warrick N, Hale AB, Cai S, Channon KM, Alp NJ.

J Biol Chem. 2009 Jan 9;284(2):1136-44. doi: 10.1074/jbc.M805403200. Epub 2008 Nov 14.

PMID:
19011239
[PubMed - indexed for MEDLINE]
Free Article
16.

Genetic and functional association of FAM5C with myocardial infarction.

Connelly JJ, Shah SH, Doss JF, Gadson S, Nelson S, Crosslin DR, Hale AB, Lou X, Wang T, Haynes C, Seo D, Crossman DC, Mooser V, Granger CB, Jones CJ, Kraus WE, Hauser ER, Gregory SG.

BMC Med Genet. 2008 Apr 22;9:33. doi: 10.1186/1471-2350-9-33.

PMID:
18430236
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets.

Sutton BS, Crosslin DR, Shah SH, Nelson SC, Bassil A, Hale AB, Haynes C, Goldschmidt-Clermont PJ, Vance JM, Seo D, Kraus WE, Gregory SG, Hauser ER.

Hum Mol Genet. 2008 May 1;17(9):1318-28. doi: 10.1093/hmg/ddn020. Epub 2008 Jan 18.

PMID:
18204052
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.

Wang L, Hauser ER, Shah SH, Pericak-Vance MA, Haynes C, Crosslin D, Harris M, Nelson S, Hale AB, Granger CB, Haines JL, Jones CJ, Crossman D, Seo D, Gregory SG, Kraus WE, Goldschmidt-Clermont PJ, Vance JM.

Am J Hum Genet. 2007 Apr;80(4):650-63. Epub 2007 Feb 8.

PMID:
17357071
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via alpha6-integrins.

Stevenson M, Hale AB, Hale SJ, Green NK, Black G, Fisher KD, Ulbrich K, Fabra A, Seymour LW.

Cancer Gene Ther. 2007 Apr;14(4):335-45. Epub 2007 Jan 19.

PMID:
17235355
[PubMed - indexed for MEDLINE]
20.

GATA2 is associated with familial early-onset coronary artery disease.

Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, Crosslin DR, Hale AB, Nelson S, Crossman DC, Granger CB, Haines JL, Jones CJ, Vance JM, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER, Gregory SG.

PLoS Genet. 2006 Aug 25;2(8):e139. Epub 2006 Jul 20.

PMID:
16934006
[PubMed - indexed for MEDLINE]
Free PMC Article

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