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Items: 1 to 20 of 39


Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.

Zylicz JJ, Dietmann S, Günesdogan U, Hackett JA, Cougot D, Lee C, Surani MA.

Elife. 2015 Nov 9;4. pii: e09571. doi: 10.7554/eLife.09571.


A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.

Tang WW, Dietmann S, Irie N, Leitch HG, Floros VI, Bradshaw CR, Hackett JA, Chinnery PF, Surani MA.

Cell. 2015 Jun 4;161(6):1453-67. doi: 10.1016/j.cell.2015.04.053.


PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos.

Kim S, Günesdogan U, Zylicz JJ, Hackett JA, Cougot D, Bao S, Lee C, Dietmann S, Allen GE, Sengupta R, Surani MA.

Mol Cell. 2014 Nov 20;56(4):564-79. doi: 10.1016/j.molcel.2014.10.003. Epub 2014 Nov 6.


Regulatory principles of pluripotency: from the ground state up.

Hackett JA, Surani MA.

Cell Stem Cell. 2014 Oct 2;15(4):416-30. doi: 10.1016/j.stem.2014.09.015. Review.


Dynamic heterogeneity and DNA methylation in embryonic stem cells.

Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB.

Mol Cell. 2014 Jul 17;55(2):319-31. doi: 10.1016/j.molcel.2014.06.029.


Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency.

Hackett JA, Dietmann S, Murakami K, Down TA, Leitch HG, Surani MA.

Stem Cell Reports. 2013 Dec 17;1(6):518-31. doi: 10.1016/j.stemcr.2013.11.010. eCollection 2013.


Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation.

Grabole N, Tischler J, Hackett JA, Kim S, Tang F, Leitch HG, Magnúsdóttir E, Surani MA.

EMBO Rep. 2013 Jul;14(7):629-37. doi: 10.1038/embor.2013.67. Epub 2013 May 14.


Beyond DNA: programming and inheritance of parental methylomes.

Hackett JA, Surani MA.

Cell. 2013 May 9;153(4):737-9. doi: 10.1016/j.cell.2013.04.044.


Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

Hackett JA, Sengupta R, Zylicz JJ, Murakami K, Lee C, Down TA, Surani MA.

Science. 2013 Jan 25;339(6118):448-52. doi: 10.1126/science.1229277. Epub 2012 Dec 6.


DNA methylation dynamics during the mammalian life cycle.

Hackett JA, Surani MA.

Philos Trans R Soc Lond B Biol Sci. 2013 Jan 5;368(1609):20110328. doi: 10.1098/rstb.2011.0328. Review.


Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Thomson JP, Lempiäinen H, Hackett JA, Nestor CE, Müller A, Bolognani F, Oakeley EJ, Schübeler D, Terranova R, Reinhardt D, Moggs JG, Meehan RR.

Genome Biol. 2012 Oct 3;13(10):R93. doi: 10.1186/gb-2012-13-10-r93.


Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline.

Hackett JA, Reddington JP, Nestor CE, Dunican DS, Branco MR, Reichmann J, Reik W, Surani MA, Adams IR, Meehan RR.

Development. 2012 Oct;139(19):3623-32. doi: 10.1242/dev.081661.


Parallel mechanisms of epigenetic reprogramming in the germline.

Hackett JA, Zylicz JJ, Surani MA.

Trends Genet. 2012 Apr;28(4):164-74. doi: 10.1016/j.tig.2012.01.005. Epub 2012 Mar 3. Review.


The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass.

Breitman I, Saraf N, Kakade M, Yellumahanthi K, White M, Hackett JA, Clements RH.

J Am Coll Surg. 2011 Apr;212(4):617-25; discussion 625-7. doi: 10.1016/j.jamcollsurg.2010.12.040.


Apoptosis and DNA methylation.

Meng HX, Hackett JA, Nestor C, Dunican DS, Madej M, Reddington JP, Pennings S, Harrison DJ, Meehan RR.

Cancers (Basel). 2011 Apr 1;3(2):1798-820. doi: 10.3390/cancers3021798.


Nutritional effect of oral supplement enriched in beta-hydroxy-beta-methylbutyrate, glutamine and arginine on resting metabolic rate after laparoscopic gastric bypass.

Clements RH, Saraf N, Kakade M, Yellumahanthi K, White M, Hackett JA.

Surg Endosc. 2011 May;25(5):1376-82. doi: 10.1007/s00464-010-1371-9. Epub 2010 Oct 17.


The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development.

Ruzov A, Savitskaya E, Hackett JA, Reddington JP, Prokhortchouk A, Madej MJ, Chekanov N, Li M, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR.

Development. 2009 Mar;136(5):729-38. doi: 10.1242/dev.025569. Epub 2009 Jan 21.


The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways.

Ruzov A, Hackett JA, Prokhortchouk A, Reddington JP, Madej MJ, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR.

Development. 2009 Mar;136(5):723-7. doi: 10.1242/dev.025577. Epub 2009 Jan 21.


Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF.

Sanford JR, Coutinho P, Hackett JA, Wang X, Ranahan W, Caceres JF.

PLoS One. 2008 Oct 8;3(10):e3369. doi: 10.1371/journal.pone.0003369.


xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function.

Dunican DS, Ruzov A, Hackett JA, Meehan RR.

Development. 2008 Apr;135(7):1295-302. doi: 10.1242/dev.016402. Epub 2008 Feb 27.

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