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Items: 1 to 20 of 57


Novel gene expression signature predictive of clinical recurrence after radical prostatectomy in early stage prostate cancer patients.

Shahabi A, Lewinger JP, Ren J, April C, Sherrod AE, Hacia JG, Daneshmand S, Gill I, Pinski JK, Fan JB, Stern MC.

Prostate. 2016 Jun 8. doi: 10.1002/pros.23211. [Epub ahead of print]


Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines.

Braverman NE, Raymond GV, Rizzo WB, Moser AB, Wilkinson ME, Stone EM, Steinberg SJ, Wangler MF, Rush ET, Hacia JG, Bose M.

Mol Genet Metab. 2016 Mar;117(3):313-21. doi: 10.1016/j.ymgme.2015.12.009. Epub 2015 Dec 23. Review.


Derivation of induced pluripotent stem cells from orangutan skin fibroblasts.

Ramaswamy K, Yik WY, Wang XM, Oliphant EN, Lu W, Shibata D, Ryder OA, Hacia JG.

BMC Res Notes. 2015 Oct 16;8:577. doi: 10.1186/s13104-015-1567-0.


Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities.

Wang XM, Yik WY, Zhang P, Lu W, Huang N, Kim BR, Shibata D, Zitting M, Chow RH, Moser AB, Steinberg SJ, Hacia JG.

Stem Cell Res Ther. 2015 Aug 29;6:158. doi: 10.1186/s13287-015-0149-3.


Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis.

Yin K, Hacia JG, Zhong Z, Paine ML.

BMC Genomics. 2014 Nov 19;15:998. doi: 10.1186/1471-2164-15-998.


The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder.

Hiebler S, Masuda T, Hacia JG, Moser AB, Faust PL, Liu A, Chowdhury N, Huang N, Lauer A, Bennett J, Watkins PA, Zack DJ, Braverman NE, Raymond GV, Steinberg SJ.

Mol Genet Metab. 2014 Apr;111(4):522-32. doi: 10.1016/j.ymgme.2014.01.008. Epub 2014 Jan 23.


Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells.

Moser AB, Hey J, Dranchak PK, Karaman MW, Zhao J, Cox LA, Ryder OA, Hacia JG.

Lipids Health Dis. 2013 Feb 4;12:10. doi: 10.1186/1476-511X-12-10.


Identification of candidate downstream targets of TGFβ signaling during palate development by genome-wide transcript profiling.

Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG.

J Cell Biochem. 2013 Apr;114(4):796-807. doi: 10.1002/jcb.24417.


The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis.

Wang XM, Yik WY, Zhang P, Lu W, Dranchak PK, Shibata D, Steinberg SJ, Hacia JG.

Stem Cell Res Ther. 2012 Oct 4;3(5):39. doi: 10.1186/scrt130.


A founder mutation in the PEX6 gene is responsible for increased incidence of Zellweger syndrome in a French Canadian population.

Levesque S, Morin C, Guay SP, Villeneuve J, Marquis P, Yik WY, Jiralerspong S, Bouchard L, Steinberg S, Hacia JG, Dewar K, Braverman NE.

BMC Med Genet. 2012 Aug 15;13:72. doi: 10.1186/1471-2350-13-72.


The circadian clock modulates enamel development.

Lacruz RS, Hacia JG, Bromage TG, Boyde A, Lei Y, Xu Y, Miller JD, Paine ML, Snead ML.

J Biol Rhythms. 2012 Jun;27(3):237-45. doi: 10.1177/0748730412442830.


A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development.

Han D, Zhao H, Parada C, Hacia JG, Bringas P Jr, Chai Y.

Development. 2012 May;139(9):1640-50. doi: 10.1242/dev.076653. Epub 2012 Mar 21.


Gene-expression analysis of early- and late-maturation-stage rat enamel organ.

Lacruz RS, Smith CE, Chen YB, Hubbard MJ, Hacia JG, Paine ML.

Eur J Oral Sci. 2011 Dec;119 Suppl 1:149-57. doi: 10.1111/j.1600-0722.2011.00881.x.


Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice.

Iwata J, Hacia JG, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y.

J Clin Invest. 2012 Mar;122(3):873-85. doi: 10.1172/JCI61498. Epub 2012 Feb 13.


Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor β (TGFβ) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis.

Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y.

J Biol Chem. 2012 Jan 20;287(4):2353-63. doi: 10.1074/jbc.M111.280974. Epub 2011 Nov 28.


Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling.

Lacruz RS, Smith CE, Bringas P Jr, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML.

J Cell Physiol. 2012 May;227(5):2264-75. doi: 10.1002/jcp.22965.


Human and great ape red blood cells differ in plasmalogen levels and composition.

Moser AB, Steinberg SJ, Watkins PA, Moser HW, Ramaswamy K, Siegmund KD, Lee DR, Ely JJ, Ryder OA, Hacia JG.

Lipids Health Dis. 2011 Jun 17;10:101. doi: 10.1186/1476-511X-10-101.


Nonsense suppressor therapies rescue peroxisome lipid metabolism and assembly in cells from patients with specific PEX gene mutations.

Dranchak PK, Di Pietro E, Snowden A, Oesch N, Braverman NE, Steinberg SJ, Hacia JG.

J Cell Biochem. 2011 May;112(5):1250-8. doi: 10.1002/jcb.22979.


Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin.

Lacruz RS, Lakshminarayanan R, Bromley KM, Hacia JG, Bromage TG, Snead ML, Moradian-Oldak J, Paine ML.

PLoS One. 2011 Mar 18;6(3):e18028. doi: 10.1371/journal.pone.0018028.


Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions.

Watkins PA, Moser AB, Toomer CB, Steinberg SJ, Moser HW, Karaman MW, Ramaswamy K, Siegmund KD, Lee DR, Ely JJ, Ryder OA, Hacia JG.

BMC Physiol. 2010 Oct 8;10:19. doi: 10.1186/1472-6793-10-19.

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