Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 2
1997 16
1998 21
1999 21
2000 38
2001 32
2002 31
2003 69
2004 38
2005 36
2006 29
2007 38
2008 34
2009 22
2010 20
2011 33
2012 15
2013 27
2014 17
2015 15
2016 11
2017 7
2018 12
2019 12
2020 13
2021 12
2022 13
2023 13
2024 5

Text availability

Article attribute

Article type

Publication date

Search Results

603 results

Results by year

Filters applied: . Clear all
Page 1
HOE-642 improves the protection of hypothermia on neuronal mitochondria after cardiac arrest in rats.
Wei L, Zhang P, Hu Y, Zhao W, Liu X, Wang X, Han F. Wei L, et al. Am J Transl Res. 2020 May 15;12(5):2181-2191. eCollection 2020. Am J Transl Res. 2020. PMID: 32509210 Free PMC article.
Five groups were included in this study: sham; normothermia (N); HOE-642 (HOE, 1 mg/kg); hypothermia (Hypo, 330.5C); and HOE-642 plus hypothermia (HOE+Hypo). ...The mitochondria maintained structural integrity in the HOE, Hypo and HOE+Hypo groups. H …
Five groups were included in this study: sham; normothermia (N); HOE-642 (HOE, 1 mg/kg); hypothermia (Hypo, 330.5C); and HO …
Exploration of the optimal dose of HOE-642 for the protection of neuronal mitochondrial function after cardiac arrest in rats.
Wei L, Zhao W, Hu Y, Wang X, Liu X, Zhang P, Han F. Wei L, et al. Biomed Pharmacother. 2019 Feb;110:818-824. doi: 10.1016/j.biopha.2018.12.035. Epub 2018 Dec 14. Biomed Pharmacother. 2019. PMID: 30554120 Free article.
Complex II and IV activities in the NORM + 3 mg and HYPO + 3 mg groups were significantly higher than in the NORM + 0 mg, NORM + 1 mg, and HYPO + 0 mg (n = 4)groups. CONCLUSIONS: HOE-642 1 or 3 mg/kg showed benefits compared to HOE-642 5 mg/kg used whe …
Complex II and IV activities in the NORM + 3 mg and HYPO + 3 mg groups were significantly higher than in the NORM + 0 mg, NORM + 1 mg, and H …
Cariporide (HOE-642) improves cardiac allograft preservation in a porcine model of orthotopic heart transplantation.
Ryan JB, Hicks M, Cropper JR, Garlick SR, Kesteven SH, Wilson MK, Feneley MP, Macdonald PS. Ryan JB, et al. Transplantation. 2003 Mar 15;75(5):625-31. doi: 10.1097/01.TP.0000054619.13962.30. Transplantation. 2003. PMID: 12640300
The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen exchanger, could reduce ischemia-reperfusion injury. ...In addition, both the donor and recipient animals in the CAR group received a single …
The aim of this study was to determine whether treating the donor and recipient with cariporide, an inhibitor of the sodium-hydrogen …
Infarct size limitation by a new Na(+)-H+ exchange inhibitor, Hoe 642: difference from preconditioning in the role of protein kinase C.
Miura T, Ogawa T, Suzuki K, Goto M, Shimamoto K. Miura T, et al. J Am Coll Cardiol. 1997 Mar 1;29(3):693-701. doi: 10.1016/s0735-1097(96)00522-0. J Am Coll Cardiol. 1997. PMID: 9060913 Free article.
In addition, we assessed the possible alteration of Hoe 642-induced cardioprotection by commonly used animal anesthetic drugs. ...In the polyB-treated rabbits, 0.6 mg/kg of Hoe 642 significantly limited infarct size (%IS/AR was 28.3 +/- 3.8% with Ho …
In addition, we assessed the possible alteration of Hoe 642-induced cardioprotection by commonly used animal anesthetic drugs. …
Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger.
O'Donnell ME, Chen YJ, Lam TI, Taylor KC, Walton JH, Anderson SE. O'Donnell ME, et al. J Cereb Blood Flow Metab. 2013 Feb;33(2):225-34. doi: 10.1038/jcbfm.2012.160. Epub 2012 Nov 14. J Cereb Blood Flow Metab. 2013. PMID: 23149557 Free PMC article.
We found that intravenous administration of the specific Na/H exchange inhibitor HOE-642 significantly decreased brain Na uptake and reduced cerebral edema, brain swelling, and infarct volume. ...
We found that intravenous administration of the specific Na/H exchange inhibitor HOE-642 significantly decreased brain Na upta …
Interaction between anesthetics and the sodium-hydrogen exchange inhibitor HOE 642 (cariporide) in ischemic and reperfused rat hearts.
Mathur S, Karmazyn M. Mathur S, et al. Anesthesiology. 1997 Dec;87(6):1460-9. doi: 10.1097/00000542-199712000-00025. Anesthesiology. 1997. PMID: 9416731 Free article.
Sufentanil had no effect in terms of developed pressure, but protection with HOE 642 was maintained. HOE 642 with or without volatile anesthetics also preserved adenosine triphosphate levels. CONCLUSIONS: Isoflurane, sevoflurane, and HOE 642 …
Sufentanil had no effect in terms of developed pressure, but protection with HOE 642 was maintained. HOE 642 wit …
Effects of the Na+/H+-exchange inhibitor Hoe 642 on intracellular pH, calcium and sodium in isolated rat ventricular myocytes.
Russ U, Balser C, Scholz W, Albus U, Lang HJ, Weichert A, Schölkens BA, Gögelein H. Russ U, et al. Pflugers Arch. 1996 Nov-Dec;433(1-2):26-34. doi: 10.1007/s004240050244. Pflugers Arch. 1996. PMID: 9019727
The inhibitors of the Na+/H+-exchange (NHE1) system Hoe 694 and Hoe 642 possess cardioprotective effects in ischaemia/reperfusion. ...Hoe 642 prevented the recovery of pHi from anoxic acidification. ...
The inhibitors of the Na+/H+-exchange (NHE1) system Hoe 694 and Hoe 642 possess cardioprotective effects in ischaemia/reperfus …
Cardioprotective effects of propofol and sevoflurane in ischemic and reperfused rat hearts: role of K(ATP) channels and interaction with the sodium-hydrogen exchange inhibitor HOE 642 (cariporide).
Mathur S, Farhangkhgoee P, Karmazyn M. Mathur S, et al. Anesthesiology. 1999 Nov;91(5):1349-60. doi: 10.1097/00000542-199911000-00027. Anesthesiology. 1999. PMID: 10551586 Free article.
BACKGROUND: Sodium ion-hydrogen ion (Na(+)-H(+)) exchange inhibitors are effective cardioprotective agents. The N(+)-H(+) exchange inhibitor HOE 642 (cariporide) has undergone clinical trials in acute coronary syndromes, including bypass surgery. ...Hearts we …
BACKGROUND: Sodium ion-hydrogen ion (Na(+)-H(+)) exchange inhibitors are effective cardioprotective agents. The N(+)-H(+) exchange inhibitor …
Role of the cardiac Na(+)/H(+)exchanger in [Ca(2+)](i)and [Na(+)](i)handling during intracellular acidosis. Effect of cariporide (Hoe 642).
Salameh A, Dhein S, Beuckelmann DJ. Salameh A, et al. Pharmacol Res. 2002 Jan;45(1):35-41. doi: 10.1006/phrs.2001.0908. Pharmacol Res. 2002. PMID: 11820859
The l -type calcium current also remained unchanged. Blockade of the Na(+)/H(+)exchanger by Hoe 642 had no influence on cells perfused at pH = 7.2 but inhibited the increase in intracellular Na(+)at pH = 6.5 (0.023 +/- 0.026 in the presence of Hoe 642 …
The l -type calcium current also remained unchanged. Blockade of the Na(+)/H(+)exchanger by Hoe 642 had no influence on cells …
603 results