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Antagonizing exosomal miR-18a-5p derived from prostate cancer cells ameliorates metastasis-induced osteoblastic lesions by targeting Hist1h2bc and activating Wnt/beta-catenin pathway.
Zeng F, Zhao C, Wang R, Ren L, Qiu H, Zou Z, Ding H, Sun Z, Li J, Dong S. Zeng F, et al. Genes Dis. 2022 Jul 30;10(4):1626-1640. doi: 10.1016/j.gendis.2022.06.007. eCollection 2023 Jul. Genes Dis. 2022. PMID: 37397518 Free PMC article.
Furthermore, miR-18a-5p was transferred to osteoblasts by exosomes derived from PCa cells and targeted the Hist1h2bc gene, resulting in Ctnnb1 up-regulation in the Wnt/beta-catenin signaling pathway. ...
Furthermore, miR-18a-5p was transferred to osteoblasts by exosomes derived from PCa cells and targeted the Hist1h2bc gene, resulting …
CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer.
Craven KE, Gökmen-Polar Y, Badve SS. Craven KE, et al. Sci Rep. 2021 Feb 25;11(1):4691. doi: 10.1038/s41598-021-83913-7. Sci Rep. 2021. PMID: 33633150 Free PMC article.
Twenty-five genes showed mutational frequency differences between the TCGA high and low T cell groups, and many play important roles in inflammation or immune evasion (ATG2B, HIST1H2BC, PKD1, PIKFYVE, TLR3, NOTCH3, GOLGB1, CREBBP). Identification of these mutations suggest …
Twenty-five genes showed mutational frequency differences between the TCGA high and low T cell groups, and many play important roles in infl …
Frequent FOXA1-Activating Mutations in Extramammary Paget's Disease.
Takeichi T, Okuno Y, Matsumoto T, Tsunoda N, Suzuki K, Tanahashi K, Kono M, Kikumori T, Muro Y, Akiyama M. Takeichi T, et al. Cancers (Basel). 2020 Mar 29;12(4):820. doi: 10.3390/cancers12040820. Cancers (Basel). 2020. PMID: 32235312 Free PMC article.
Additional mutations were identified in PIK3CA (six patients) and in HIST1H2BB, HIST1H2BC, and SMARCB1 (one patient each), but none were found in other frequently mutated genes in cancer. ...
Additional mutations were identified in PIK3CA (six patients) and in HIST1H2BB, HIST1H2BC, and SMARCB1 (one patient each), but none w …
Immune-relevant genes of systemic lupus erythematosus by transcriptome profiling analysis.
Lv J, Chen L, Wang X, Gao Q, Zhao L. Lv J, et al. Cytokine. 2022 Oct;158:155975. doi: 10.1016/j.cyto.2022.155975. Epub 2022 Aug 11. Cytokine. 2022. PMID: 35964416
Genes in the lncRNA-mRNA co-expression network were significantly enriched in primary immunodeficiency, hematopoietic cell lineage, B cell receptor signaling pathway, SLE (up-regulated FCGR3A, down-regulated CD40LG, up-regulated HIST1H2BE, down-regulated human leukocyte antigen [ …
Genes in the lncRNA-mRNA co-expression network were significantly enriched in primary immunodeficiency, hematopoietic cell lineage, B cell r …
Neutrophil-related genes predict prognosis and response to immune checkpoint inhibitors in bladder cancer.
Yang R, Zhang W, Shang X, Chen H, Mu X, Zhang Y, Zheng Q, Wang X, Liu Y. Yang R, et al. Front Pharmacol. 2022 Oct 21;13:1013672. doi: 10.3389/fphar.2022.1013672. eCollection 2022. Front Pharmacol. 2022. PMID: 36339597 Free PMC article.
We established a neutrophil-based prognostic model incorporating five neutrophil-related genes (EMR3, VNN1, FCGRT, HIST1H2BC, and MX1) and the predictive value of the model was validated in both an internal and an external validation cohort. ...
We established a neutrophil-based prognostic model incorporating five neutrophil-related genes (EMR3, VNN1, FCGRT, HIST1H2BC, and MX1 …
A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues.
Lyons SM, Cunningham CH, Welch JD, Groh B, Guo AY, Wei B, Whitfield ML, Xiong Y, Marzluff WF. Lyons SM, et al. Nucleic Acids Res. 2016 Nov 2;44(19):9190-9205. doi: 10.1093/nar/gkw620. Epub 2016 Jul 8. Nucleic Acids Res. 2016. PMID: 27402160 Free PMC article.
We report that a subset of RD-histone genes are expressed in terminally differentiated tissues as polyadenylated mRNAs, likely serving as replacement histone genes in long-lived non-dividing cells. Expression of two genes, HIST2H2AA3 and HIST1H2BC, is conserved in mammals. …
We report that a subset of RD-histone genes are expressed in terminally differentiated tissues as polyadenylated mRNAs, likely serving as re …
Transcriptome study of differential expression in schizophrenia.
Sanders AR, Göring HH, Duan J, Drigalenko EI, Moy W, Freda J, He D, Shi J; MGS; Gejman PV. Sanders AR, et al. Hum Mol Genet. 2013 Dec 15;22(24):5001-14. doi: 10.1093/hmg/ddt350. Epub 2013 Jul 30. Hum Mol Genet. 2013. PMID: 23904455 Free PMC article.
The observed differential expression of extended major histocompatibility complex (xMHC) region histones (HIST1H2BD, HIST1H2BC, HIST1H2BH, HIST1H2BG and HIST1H4K) converges with the genetic evidence from GWAS, which find the xMHC to be the most significant susceptibility l …
The observed differential expression of extended major histocompatibility complex (xMHC) region histones (HIST1H2BD, HIST1H2BC, HIST1 …
The Predictive Value of Neutrophil Extracellular Trap-Related Risk Score in Prognosis and Immune Microenvironment of Colorectal Cancer Patients.
Dong J, Zhao J, Wu Z, Liu J, Wang B, Qi X. Dong J, et al. Mol Biotechnol. 2024 Apr 5. doi: 10.1007/s12033-024-01135-4. Online ahead of print. Mol Biotechnol. 2024. PMID: 38580851
NET risk score was built for CRC patients, basing on G0S2, HIST1H2BC, CRISPLD2, and IL17A. In TCGA-CRC and validation datasets, regardless of age or gender, high-risk CRC patients had significantly worse prognosis, besides higher NET risk score was mainly found in samples …
NET risk score was built for CRC patients, basing on G0S2, HIST1H2BC, CRISPLD2, and IL17A. In TCGA-CRC and validation datasets, regar …
Reduced Expression of Antimicrobial Protein Secretory Leukoprotease Inhibitor and Clusterin in Chronic Rhinosinusitis with Nasal Polyps.
Huang Y, Wang M, Hong Y, Bu X, Luan G, Wang Y, Li Y, Lou H, Wang C, Zhang L. Huang Y, et al. J Immunol Res. 2021 Jan 7;2021:1057186. doi: 10.1155/2021/1057186. eCollection 2021. J Immunol Res. 2021. PMID: 33506054 Free PMC article. Clinical Trial.
RESULTS: The 10 most abundant AMPs expressed differentially in CRSwNP compared to healthy control, regardless of subtypes, included BPIFA1, BPIFB1, BPIFB2, CLU, LTF, LYZ, and SLPI, which were downregulated, and S100A8, S100A9, and HIST1H2BC, which were upregulated. ELISA a …
RESULTS: The 10 most abundant AMPs expressed differentially in CRSwNP compared to healthy control, regardless of subtypes, included BPIFA1, …
Traditional Chinese medicine classification of knee osteoarthritis with proteomics analysis.
Sun Q, Zhang K, Chen J, Xu Y, Liu Y, Zheng R. Sun Q, et al. Ann Palliat Med. 2020 Nov;9(6):3750-3756. doi: 10.21037/apm-20-2117. Ann Palliat Med. 2020. PMID: 33302647 Free article.
Histone H4, histone H2A, S100 calbindin A8, fibrinogen gamma, fiber protein alpha, cDNA (FLJ92148), C4b binding protein, and partial transketolase variants were down-regulation, and basement membrane glycan was up-regulation in the treatment group compared with the control group …
Histone H4, histone H2A, S100 calbindin A8, fibrinogen gamma, fiber protein alpha, cDNA (FLJ92148), C4b binding protein, and partial transke …
12 results