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Results: 1 to 20 of 49


The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion.

Laragione T, Cheng KF, Tanner MR, He M, Beeton C, Al-Abed Y, Gulko PS.

Clin Immunol. 2015 Jun;158(2):183-92. doi: 10.1016/j.clim.2015.04.001. Epub 2015 Apr 11.


KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis.

Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Gulko PS, Beeton C.

Arthritis Rheumatol. 2015 Jan;67(1):96-106. doi: 10.1002/art.38883.


Analyses of synovial tissues from arthritic and protected congenic rat strains reveal a new core set of genes associated with disease severity.

Brenner M, Laragione T, Gulko PS.

Physiol Genomics. 2013 Nov 15;45(22):1109-22. doi: 10.1152/physiolgenomics.00108.2013. Epub 2013 Sep 17.


The multiple chemokine-binding Bovine Herpesvirus 1 Glycoprotein G (BHV1gG) inhibits polymorphonuclear cell but not monocyte migration into inflammatory sites.

Liu Z, Bethunaickan R, Sahu R, Brenner M, Laragione T, Gulko PS, Davidson A.

Mol Med. 2013 Aug 21. doi: 10.2119/molmed.2013.00339. [Epub ahead of print]


Arthritis severity locus Cia4 is an early regulator of IL-6, IL-1β, and NF-κB activators' expression in pristane-induced arthritis.

Brenner M, Laragione T, Gulko PS.

Physiol Genomics. 2013 Jul 2;45(13):552-64. doi: 10.1152/physiolgenomics.00029.2013. Epub 2013 May 21.


Whole-genome sequences of DA and F344 rats with different susceptibilities to arthritis, autoimmunity, inflammation and cancer.

Guo X, Brenner M, Zhang X, Laragione T, Tai S, Li Y, Bu J, Yin Y, Shah AA, Kwan K, Li Y, Jun W, Gulko PS.

Genetics. 2013 Aug;194(4):1017-28. doi: 10.1534/genetics.113.153049. Epub 2013 May 20.


Identification of two new arthritis severity loci that regulate levels of autoantibodies, interleukin-1β, and joint damage in pristane- and collagen-induced arthritis.

Brenner M, Laragione T, Shah A, Mello A, Remmers EF, Wilder RL, Gulko PS.

Arthritis Rheum. 2012 May;64(5):1369-78. doi: 10.1002/art.33468.


KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis.

Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Gulko PS, Beeton C.

J Biol Chem. 2012 Feb 3;287(6):4014-22. doi: 10.1074/jbc.M111.312264. Epub 2011 Nov 10.


The vitamin D receptor regulates rheumatoid arthritis synovial fibroblast invasion and morphology.

Laragione T, Shah A, Gulko PS.

Mol Med. 2012 Mar 27;18:194-200. doi: 10.2119/molmed.2011.00410.


Synovial expression of Th17-related and cancer-associated genes is regulated by the arthritis severity locus Cia10.

Jenkins E, Brenner M, Laragione T, Gulko PS.

Genes Immun. 2012 Apr;13(3):221-31. doi: 10.1038/gene.2011.73. Epub 2011 Nov 3.


CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis.

Laragione T, Brenner M, Sherry B, Gulko PS.

Arthritis Rheum. 2011 Nov;63(11):3274-83. doi: 10.1002/art.30573.


Strain differences in alveolar neutrophil infiltration and macrophage phenotypes in an acute lung inflammation model.

Zhang Y, Lin X, Koga K, Takahashi K, Linge HM, Mello A, Laragione T, Gulko PS, Miller EJ.

Mol Med. 2011;17(7-8):780-9. doi: 10.2119/molmed.2010.00064. Epub 2011 Apr 28.


mTOR regulates the invasive properties of synovial fibroblasts in rheumatoid arthritis.

Laragione T, Gulko PS.

Mol Med. 2010 Sep-Oct;16(9-10):352-8. doi: 10.2119/molmed.2010.00049. Epub 2010 May 27.


A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock.

Johannesson M, Lopez-Aumatell R, Stridh P, Diez M, Tuncel J, Blázquez G, Martinez-Membrives E, Cañete T, Vicens-Costa E, Graham D, Copley RR, Hernandez-Pliego P, Beyeen AD, Ockinger J, Fernández-Santamaría C, Gulko PS, Brenner M, Tobeña A, Guitart-Masip M, Giménez-Llort L, Dominiczak A, Holmdahl R, Gauguier D, Olsson T, Mott R, Valdar W, Redei EE, Fernández-Teruel A, Flint J.

Genome Res. 2009 Jan;19(1):150-8. doi: 10.1101/gr.081497.108. Epub 2008 Oct 29.


Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature.

Laragione T, Brenner M, Li W, Gulko PS.

Arthritis Res Ther. 2008;10(4):R92. doi: 10.1186/ar2476. Epub 2008 Aug 15.


The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts.

Laragione T, Brenner M, Mello A, Symons M, Gulko PS.

Arthritis Rheum. 2008 Aug;58(8):2296-306. doi: 10.1002/art.23610.

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