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Results: 1 to 20 of 86

1.

Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases.

Hocková D, Janeba Z, Naesens L, Edstein MD, Chavchich M, Keough DT, Guddat LW.

Bioorg Med Chem. 2015 Sep 1;23(17):5502-10. doi: 10.1016/j.bmc.2015.07.038. Epub 2015 Jul 27.

PMID:
26275679
2.

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.

Eng WS, Hocková D, Špaček P, Janeba Z, West NP, Woods K, Naesens LM, Keough DT, Guddat LW.

J Med Chem. 2015 Jun 11;58(11):4822-38. doi: 10.1021/acs.jmedchem.5b00611. Epub 2015 May 13.

PMID:
25915781
3.

Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring.

Pohl R, Poštová Slavětínská L, Eng WS, Keough DT, Guddat LW, Rejman D.

Org Biomol Chem. 2015 Apr 28;13(16):4693-705. doi: 10.1039/c5ob00097a.

PMID:
25798893
4.

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.

Keough DT, Hocková D, Janeba Z, Wang TH, Naesens L, Edstein MD, Chavchich M, Guddat LW.

J Med Chem. 2015 Jan 22;58(2):827-46. doi: 10.1021/jm501416t. Epub 2014 Dec 24.

PMID:
25494538
5.

The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-β-lactamases and arginases.

McGeary RP, Schenk G, Guddat LW.

Eur J Med Chem. 2014 Apr 9;76:132-44. doi: 10.1016/j.ejmech.2014.02.008. Epub 2014 Feb 8. Review.

PMID:
24583353
6.

Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry.

Pedroso MM, Ely F, Lonhienne T, Gahan LR, Ollis DL, Guddat LW, Schenk G.

J Biol Inorg Chem. 2014 Mar;19(3):389-98. doi: 10.1007/s00775-013-1079-0. Epub 2014 Jan 12.

PMID:
24414447
7.

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.

Keough DT, Hocková D, Rejman D, Spaček P, Vrbková S, Krečmerová M, Eng WS, Jans H, West NP, Naesens LM, de Jersey J, Guddat LW.

J Med Chem. 2013 Sep 12;56(17):6967-84. doi: 10.1021/jm400779n. Epub 2013 Aug 27.

PMID:
23927482
8.

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir).

Naesens L, Guddat LW, Keough DT, van Kuilenburg AB, Meijer J, Vande Voorde J, Balzarini J.

Mol Pharmacol. 2013 Oct;84(4):615-29. doi: 10.1124/mol.113.087247. Epub 2013 Aug 1.

9.

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Baszczyňski O, Hocková D, Janeba Z, Holý A, Jansa P, Dračínský M, Keough DT, Guddat LW.

Eur J Med Chem. 2013 Sep;67:81-9. doi: 10.1016/j.ejmech.2013.06.032. Epub 2013 Jun 22.

PMID:
23850568
10.

Acetohydroxyacid synthase: a target for antimicrobial drug discovery.

Pue N, Guddat LW.

Curr Pharm Des. 2014;20(5):740-53.

PMID:
23688082
11.

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.

Keough DT, Špaček P, Hocková D, Tichý T, Vrbková S, Slavětínská L, Janeba Z, Naesens L, Edstein MD, Chavchich M, Wang TH, de Jersey J, Guddat LW.

J Med Chem. 2013 Mar 28;56(6):2513-26. doi: 10.1021/jm301893b. Epub 2013 Mar 19.

PMID:
23448281
12.

The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake.

Millers EK, Johnson LA, Birrell GW, Masci PP, Lavin MF, de Jersey J, Guddat LW.

PLoS One. 2013;8(1):e54104. doi: 10.1371/journal.pone.0054104. Epub 2013 Jan 15.

13.

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.

Lee YT, Cui CJ, Chow EW, Pue N, Lonhienne T, Wang JG, Fraser JA, Guddat LW.

J Med Chem. 2013 Jan 10;56(1):210-9. doi: 10.1021/jm301501k. Epub 2012 Dec 31.

PMID:
23237384
14.

Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle.

Wong SH, Lonhienne TG, Winzor DJ, Schenk G, Guddat LW.

J Mol Biol. 2012 Dec 7;424(3-4):168-79. doi: 10.1016/j.jmb.2012.09.018. Epub 2012 Oct 2.

PMID:
23036858
15.

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.

Feder D, Hussein WM, Clayton DJ, Kan MW, Schenk G, McGeary RP, Guddat LW.

Chem Biol Drug Des. 2012 Nov;80(5):665-74. doi: 10.1111/cbdd.12001. Epub 2012 Sep 3.

PMID:
22943065
16.

A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.

Liu L, Li C, Cochran S, Feder D, Guddat LW, Ferro V.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6190-4. doi: 10.1016/j.bmcl.2012.08.001. Epub 2012 Aug 10.

PMID:
22929233
17.

Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.

Hocková D, Keough DT, Janeba Z, Wang TH, de Jersey J, Guddat LW.

J Med Chem. 2012 Jul 12;55(13):6209-23. doi: 10.1021/jm300662d. Epub 2012 Jun 22.

PMID:
22725979
18.

Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction.

Schenk G, Mitić N, Gahan LR, Ollis DL, McGeary RP, Guddat LW.

Acc Chem Res. 2012 Sep 18;45(9):1593-603. Epub 2012 Jun 14. Review.

PMID:
22698580
19.

Penicillin inhibitors of purple acid phosphatase.

Faridoon, Hussein WM, Ul Islam N, Guddat LW, Schenk G, McGeary RP.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2555-9. doi: 10.1016/j.bmcl.2012.01.123. Epub 2012 Feb 4.

PMID:
22366658
20.

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.

Krečmerová M, Dračínský M, Hocková D, Holý A, Keough DT, Guddat LW.

Bioorg Med Chem. 2012 Feb 1;20(3):1222-30. doi: 10.1016/j.bmc.2011.12.034. Epub 2011 Dec 30.

PMID:
22249123
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