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Results: 1 to 20 of 82

1.

The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-β-lactamases and arginases.

McGeary RP, Schenk G, Guddat LW.

Eur J Med Chem. 2014 Apr 9;76:132-44. doi: 10.1016/j.ejmech.2014.02.008. Epub 2014 Feb 8.

PMID:
24583353
[PubMed - in process]
2.

Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry.

Pedroso MM, Ely F, Lonhienne T, Gahan LR, Ollis DL, Guddat LW, Schenk G.

J Biol Inorg Chem. 2014 Mar;19(3):389-98. doi: 10.1007/s00775-013-1079-0. Epub 2014 Jan 12.

PMID:
24414447
[PubMed - in process]
3.

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.

Keough DT, Hocková D, Rejman D, Spaček P, Vrbková S, Krečmerová M, Eng WS, Jans H, West NP, Naesens LM, de Jersey J, Guddat LW.

J Med Chem. 2013 Sep 12;56(17):6967-84. doi: 10.1021/jm400779n. Epub 2013 Aug 27.

PMID:
23927482
[PubMed - indexed for MEDLINE]
4.

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir).

Naesens L, Guddat LW, Keough DT, van Kuilenburg AB, Meijer J, Vande Voorde J, Balzarini J.

Mol Pharmacol. 2013 Oct;84(4):615-29. doi: 10.1124/mol.113.087247. Epub 2013 Aug 1.

PMID:
23907213
[PubMed - indexed for MEDLINE]
Free Article
5.

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Baszczyňski O, Hocková D, Janeba Z, Holý A, Jansa P, Dračínský M, Keough DT, Guddat LW.

Eur J Med Chem. 2013 Sep;67:81-9. doi: 10.1016/j.ejmech.2013.06.032. Epub 2013 Jun 22.

PMID:
23850568
[PubMed - indexed for MEDLINE]
6.

Acetohydroxyacid synthase: a target for antimicrobial drug discovery.

Pue N, Guddat LW.

Curr Pharm Des. 2014;20(5):740-53.

PMID:
23688082
[PubMed - in process]
7.

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.

Keough DT, Špaček P, Hocková D, Tichý T, Vrbková S, Slavětínská L, Janeba Z, Naesens L, Edstein MD, Chavchich M, Wang TH, de Jersey J, Guddat LW.

J Med Chem. 2013 Mar 28;56(6):2513-26. doi: 10.1021/jm301893b. Epub 2013 Mar 19.

PMID:
23448281
[PubMed - indexed for MEDLINE]
8.

The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake.

Millers EK, Johnson LA, Birrell GW, Masci PP, Lavin MF, de Jersey J, Guddat LW.

PLoS One. 2013;8(1):e54104. doi: 10.1371/journal.pone.0054104. Epub 2013 Jan 15.

PMID:
23335990
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.

Lee YT, Cui CJ, Chow EW, Pue N, Lonhienne T, Wang JG, Fraser JA, Guddat LW.

J Med Chem. 2013 Jan 10;56(1):210-9. doi: 10.1021/jm301501k. Epub 2012 Dec 31.

PMID:
23237384
[PubMed - indexed for MEDLINE]
10.

Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle.

Wong SH, Lonhienne TG, Winzor DJ, Schenk G, Guddat LW.

J Mol Biol. 2012 Dec 7;424(3-4):168-79. doi: 10.1016/j.jmb.2012.09.018. Epub 2012 Oct 2.

PMID:
23036858
[PubMed - indexed for MEDLINE]
11.

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.

Feder D, Hussein WM, Clayton DJ, Kan MW, Schenk G, McGeary RP, Guddat LW.

Chem Biol Drug Des. 2012 Nov;80(5):665-74. doi: 10.1111/cbdd.12001. Epub 2012 Sep 3.

PMID:
22943065
[PubMed - indexed for MEDLINE]
12.

A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.

Liu L, Li C, Cochran S, Feder D, Guddat LW, Ferro V.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6190-4. doi: 10.1016/j.bmcl.2012.08.001. Epub 2012 Aug 10.

PMID:
22929233
[PubMed - indexed for MEDLINE]
13.

Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.

Hocková D, Keough DT, Janeba Z, Wang TH, de Jersey J, Guddat LW.

J Med Chem. 2012 Jul 12;55(13):6209-23. doi: 10.1021/jm300662d. Epub 2012 Jun 22.

PMID:
22725979
[PubMed - indexed for MEDLINE]
14.

Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction.

Schenk G, Mitić N, Gahan LR, Ollis DL, McGeary RP, Guddat LW.

Acc Chem Res. 2012 Sep 18;45(9):1593-603. Epub 2012 Jun 14. Review.

PMID:
22698580
[PubMed - indexed for MEDLINE]
15.

Penicillin inhibitors of purple acid phosphatase.

Faridoon, Hussein WM, Ul Islam N, Guddat LW, Schenk G, McGeary RP.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2555-9. doi: 10.1016/j.bmcl.2012.01.123. Epub 2012 Feb 4.

PMID:
22366658
[PubMed - indexed for MEDLINE]
16.

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.

Krečmerová M, Dračínský M, Hocková D, Holý A, Keough DT, Guddat LW.

Bioorg Med Chem. 2012 Feb 1;20(3):1222-30. doi: 10.1016/j.bmc.2011.12.034. Epub 2011 Dec 30.

PMID:
22249123
[PubMed - indexed for MEDLINE]
17.

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Česnek M, Hocková D, Holý A, Dračínský M, Baszczyňski O, Jersey Jd, Keough DT, Guddat LW.

Bioorg Med Chem. 2012 Jan 15;20(2):1076-89. doi: 10.1016/j.bmc.2011.11.034. Epub 2011 Dec 1.

PMID:
22178188
[PubMed - indexed for MEDLINE]
18.

Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter.

Ely F, Pedroso MM, Gahan LR, Ollis DL, Guddat LW, Schenk G.

J Inorg Biochem. 2012 Jan;106(1):19-22. doi: 10.1016/j.jinorgbio.2011.09.015. Epub 2011 Sep 17.

PMID:
22112835
[PubMed - indexed for MEDLINE]
19.

Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives.

Wang J, Tan H, Li Y, Ma Y, Li Z, Guddat LW.

J Agric Food Chem. 2011 Sep 28;59(18):9892-900. doi: 10.1021/jf2021607. Epub 2011 Aug 25.

PMID:
21838297
[PubMed - indexed for MEDLINE]
20.

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs.

de Jersey J, Holý A, Hocková D, Naesens L, Keough DT, Guddat LW.

Curr Top Med Chem. 2011;11(16):2085-102. Review.

PMID:
21619515
[PubMed - indexed for MEDLINE]

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