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Results: 1 to 20 of 188

1.

Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R.

Parameswaran R, Lim M, Fei F, Abdel-Azim H, Arutyunyan A, Schiffer I, McLaughlin ME, Gram H, Huet H, Groffen J, Heisterkamp N.

Mol Cancer Ther. 2014 Jun;13(6):1567-77. doi: 10.1158/1535-7163.MCT-13-1023. Epub 2014 May 13.

PMID:
24825858
[PubMed - in process]
2.

Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model.

Gong D, Fei F, Lim M, Yu M, Groffen J, Heisterkamp N.

J Immunol. 2013 Nov 1;191(9):4514-20. doi: 10.4049/jimmunol.1202603. Epub 2013 Sep 20.

PMID:
24058174
[PubMed - indexed for MEDLINE]
3.

Galectin-3 in pre-B acute lymphoblastic leukemia.

Fei F, Abdel-Azim H, Lim M, Arutyunyan A, von Itzstein M, Groffen J, Heisterkamp N.

Leukemia. 2013 Dec;27(12):2385-8. doi: 10.1038/leu.2013.175. Epub 2013 Jun 13. No abstract available.

PMID:
23760399
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia.

Parameswaran R, Lim M, Arutyunyan A, Abdel-Azim H, Hurtz C, Lau K, Müschen M, Yu RK, von Itzstein M, Heisterkamp N, Groffen J.

J Exp Med. 2013 Apr 8;210(4):805-19. doi: 10.1084/jem.20121482. Epub 2013 Mar 11.

PMID:
23478187
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice.

Yu M, Gong D, Lim M, Arutyunyan A, Groffen J, Heisterkamp N.

PLoS One. 2012;7(11):e49756. doi: 10.1371/journal.pone.0049756. Epub 2012 Nov 12.

PMID:
23152932
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia.

Feldhahn N, Arutyunyan A, Stoddart S, Zhang B, Schmidhuber S, Yi SJ, Kim YM, Groffen J, Heisterkamp N.

Oncoimmunology. 2012 Aug 1;1(5):618-629.

PMID:
22934254
[PubMed]
Free PMC Article
7.

Expression of cassini, a murine gamma-satellite sequence conserved in evolution, is regulated in normal and malignant hematopoietic cells.

Arutyunyan A, Stoddart S, Yi SJ, Fei F, Lim M, Groffen P, Feldhahn N, Groffen J, Heisterkamp N.

BMC Genomics. 2012 Aug 23;13:418. doi: 10.1186/1471-2164-13-418.

PMID:
22916712
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib).

Fei F, Lim M, Schmidhuber S, Moll J, Groffen J, Heisterkamp N.

Mol Cancer. 2012 Jun 21;11:42. doi: 10.1186/1476-4598-11-42.

PMID:
22721004
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

TGFβ signaling plays a critical role in promoting alternative macrophage activation.

Gong D, Shi W, Yi SJ, Chen H, Groffen J, Heisterkamp N.

BMC Immunol. 2012 Jun 15;13:31. doi: 10.1186/1471-2172-13-31.

PMID:
22703233
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin.

Parameswaran R, Yu M, Lyu MA, Lim M, Rosenblum MG, Groffen J, Heisterkamp N.

Leukemia. 2012 Aug;26(8):1786-96. doi: 10.1038/leu.2012.54. Epub 2012 Feb 29.

PMID:
22373785
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist.

Parameswaran R, Yu M, Lim M, Groffen J, Heisterkamp N.

Leukemia. 2011 Aug;25(8):1314-23. doi: 10.1038/leu.2011.76. Epub 2011 Apr 12.

PMID:
21483439
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

AMD3100 sensitizes acute lymphoblastic leukemia cells to chemotherapy in vivo.

Yu M, Gang EJ, Parameswaran R, Stoddart S, Fei F, Schmidhuber S, Park E, Hsieh YT, Yang AS, Groffen J, Heisterkamp N, Kim YM.

Blood Cancer J. 2011 Apr;1(4):e14. doi: 10.1038/bcj.2011.13. Epub 2011 Apr 1. No abstract available.

PMID:
22829135
[PubMed]
Free PMC Article
13.

Bcr is a substrate for Transglutaminase 2 cross-linking activity.

Yi SJ, Groffen J, Heisterkamp N.

BMC Biochem. 2011 Feb 10;12:8. doi: 10.1186/1471-2091-12-8.

PMID:
21310073
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac.

Fei F, Kweon SM, Haataja L, De Sepulveda P, Groffen J, Heisterkamp N.

BMC Biochem. 2010 Dec 1;11:48. doi: 10.1186/1471-2091-11-48.

PMID:
21122136
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

Oh D, Han S, Seo J, Lee JR, Choi J, Groffen J, Kim K, Cho YS, Choi HS, Shin H, Woo J, Won H, Park SK, Kim SY, Jo J, Whitcomb DJ, Cho K, Kim H, Bae YC, Heisterkamp N, Choi SY, Kim E.

J Neurosci. 2010 Oct 20;30(42):14134-44. doi: 10.1523/JNEUROSCI.1711-10.2010.

PMID:
20962234
[PubMed - indexed for MEDLINE]
Free Article
16.

Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models.

Yun JP, Behan JW, Heisterkamp N, Butturini A, Klemm L, Ji L, Groffen J, Müschen M, Mittelman SD.

Cancer Prev Res (Phila). 2010 Oct;3(10):1259-64. doi: 10.1158/1940-6207.CAPR-10-0087. Epub 2010 Sep 7.

PMID:
20823291
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair.

Li A, Xing Y, Chan B, Heisterkamp N, Groffen J, Borok Z, Minoo P, Li C.

Dev Dyn. 2010 Aug;239(8):2288-97. doi: 10.1002/dvdy.22364.

PMID:
20658693
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A functional receptor for B-cell-activating factor is expressed on human acute lymphoblastic leukemias.

Parameswaran R, Müschen M, Kim YM, Groffen J, Heisterkamp N.

Cancer Res. 2010 Jun 1;70(11):4346-56. doi: 10.1158/0008-5472.CAN-10-0300. Epub 2010 May 11.

PMID:
20460528
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias.

Fei F, Stoddart S, Groffen J, Heisterkamp N.

Mol Cancer Ther. 2010 May;9(5):1318-27. doi: 10.1158/1535-7163.MCT-10-0069. Epub 2010 Apr 13.

PMID:
20388735
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia.

Fei F, Stoddart S, Müschen M, Kim YM, Groffen J, Heisterkamp N.

Leukemia. 2010 Apr;24(4):813-20. doi: 10.1038/leu.2009.302. Epub 2010 Jan 28.

PMID:
20111071
[PubMed - indexed for MEDLINE]
Free PMC Article

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