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Results: 1 to 20 of 405

1.

TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits.

Diogo D, Bastarache L, Liao KP, Graham RR, Fulton RS, Greenberg JD, Eyre S, Bowes J, Cui J, Lee A, Pappas DA, Kremer JM, Barton A, Coenen MJ, Franke B, Kiemeney LA, Mariette X, Richard-Miceli C, Canhão H, Fonseca JE, de Vries N, Tak PP, Crusius JB, Nurmohamed MT, Kurreeman F, Mikuls TR, Okada Y, Stahl EA, Larson DE, Deluca TL, O'Laughlin M, Fronick CC, Fulton LL, Kosoy R, Ransom M, Bhangale TR, Ortmann W, Cagan A, Gainer V, Karlson EW, Kohane I, Murphy SN, Martin J, Zhernakova A, Klareskog L, Padyukov L, Worthington J, Mardis ER, Seldin MF, Gregersen PK, Behrens T, Raychaudhuri S, Denny JC, Plenge RM.

PLoS One. 2015 Apr 7;10(4):e0122271. doi: 10.1371/journal.pone.0122271. eCollection 2015.

2.

Expression of Blimp-1 in dendritic cells modulates the innate inflammatory response in DSS induced colitis.

Kim SJ, Goldstein J, Dorso K, Merad M, Mayer L, Crawford JM, Gregersen PK, Diamond B.

Mol Med. 2014 Dec 17. doi: 10.2119/molmed.2014.00231. [Epub ahead of print]

PMID:
25826676
3.

A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility.

Carmona FD, Mackie SL, Martín JE, Taylor JC, Vaglio A, Eyre S, Bossini-Castillo L, Castañeda S, Cid MC, Hernández-Rodríguez J, Prieto-González S, Solans R, Ramentol-Sintas M, González-Escribano MF, Ortiz-Fernández L, Morado IC, Narváez J, Miranda-Filloy JA; Spanish GCA Group, Beretta L, Lunardi C, Cimmino MA, Gianfreda D, Santilli D, Ramirez GA, Soriano A, Muratore F, Pazzola G, Addimanda O, Wijmenga C, Witte T, Schirmer JH, Moosig F, Schönau V, Franke A, Palm Ø, Molberg Ø, Diamantopoulos AP, Carette S, Cuthbertson D, Forbess LJ, Hoffman GS, Khalidi NA, Koening CL, Langford CA, McAlear CA, Moreland L, Monach PA, Pagnoux C, Seo P, Spiera R, Sreih AG, Warrington KJ, Ytterberg SR, Gregersen PK, Pease CT, Gough A, Green M, Hordon L, Jarrett S, Watts R, Levy S, Patel Y, Kamath S, Dasgupta B, Worthington J, Koeleman BP, de Bakker PI, Barrett JH, Salvarani C, Merkel PA, González-Gay MA, Morgan AW, Martín J.

Am J Hum Genet. 2015 Apr 2;96(4):565-80. doi: 10.1016/j.ajhg.2015.02.009. Epub 2015 Mar 26.

PMID:
25817017
4.

Enrichment of Genetic Variants for Rheumatoid Arthritis Within T-cell and NK-cell Enhancer Regions.

Freudenberg J, Gregersen P, Li W.

Mol Med. 2015 Mar 16. doi: 10.2119/molmed.2014.00252. [Epub ahead of print]

5.

Double-blind randomized placebo-controlled trial of the effect of vitamin D3 on the interferon signature in patients with systemic lupus erythematosus.

Aranow C, Kamen DL, Dall'Era M, Massarotti EM, Mackay MC, Koumpouras F, Coca A, Chatham WW, Clowse ME, Criscione-Schreiber LG, Callahan S, Goldmuntz EA, Keyes-Elstein L, Oswald M, Gregersen PK, Diamond B.

Arthritis Rheumatol. 2015 Mar 16. doi: 10.1002/art.39108. [Epub ahead of print]

PMID:
25777546
6.

Medication Review and Patient Outcomes in an Orthopedic Department: A Randomized Controlled Study.

Lisby M, Bonnerup DK, Brock B, Gregersen PA, Jensen J, Larsen ML, Rungby J, Sonne J, Mainz J, Nielsen LP.

J Patient Saf. 2015 Mar 4. [Epub ahead of print]

PMID:
25742062
7.

Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.

Betz RC, Petukhova L, Ripke S, Huang H, Menelaou A, Redler S, Becker T, Heilmann S, Yamany T, Duvic M, Hordinsky M, Norris D, Price VH, Mackay-Wiggan J, de Jong A, DeStefano GM, Moebus S, Böhm M, Blume-Peytavi U, Wolff H, Lutz G, Kruse R, Bian L, Amos CI, Lee A, Gregersen PK, Blaumeiser B, Altshuler D, Clynes R, de Bakker PI, Nöthen MM, Daly MJ, Christiano AM.

Nat Commun. 2015 Jan 22;6:5966. doi: 10.1038/ncomms6966.

PMID:
25608926
8.

Benzoxazinoids: Cereal phytochemicals with putative therapeutic and health-protecting properties.

Adhikari KB, Tanwir F, Gregersen PL, Steffensen SK, Jensen BM, Poulsen LK, Nielsen CH, Høyer S, Borre M, Fomsgaard IS.

Mol Nutr Food Res. 2015 Jan 19. doi: 10.1002/mnfr.201400717. [Epub ahead of print]

PMID:
25600612
9.

Association of Valine and Leucine at HLA-DRB1 Position 11 With Radiographic Progression in Rheumatoid Arthritis, Independent of the Shared Epitope Alleles but Not Independent of Anti-Citrullinated Protein Antibodies.

van Steenbergen HW, Raychaudhuri S, Rodríguez-Rodríguez L, Rantapää-Dahlqvist S, Berglin E, Toes RE, Huizinga TW, Fernández-Gutiérrez B, Gregersen PK, van der Helm-van Mil AH.

Arthritis Rheumatol. 2015 Apr;67(4):877-86. doi: 10.1002/art.39018.

PMID:
25580908
10.

A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis.

van Steenbergen HW, Rodríguez-Rodríguez L, Berglin E, Zhernakova A, Knevel R, Ivorra-Cortés J, Huizinga TW, Fernández-Gutiérrez B, Gregersen PK, Rantapää-Dahlqvist S, van der Helm-van Mil AH.

Arthritis Res Ther. 2015 Jan 8;17:1. doi: 10.1186/s13075-014-0514-0.

11.

HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: hierarchical classification systems, amino acid positions, and residues.

Reynolds RJ, Ahmed AF, Danila MI, Hughes LB; Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis Investigators, Gregersen PK, Raychaudhuri S, Plenge RM, Bridges SL Jr.

Arthritis Rheumatol. 2014 Dec;66(12):3274-82. doi: 10.1002/art.38855.

PMID:
25524867
12.

A role for noncoding variation in schizophrenia.

Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Plenge RM, Raychaudhuri S, Fromer M, Purcell SM, Brennand KJ, Robakis NK, Schadt EE, Akbarian S, Sklar P.

Cell Rep. 2014 Nov 20;9(4):1417-29. doi: 10.1016/j.celrep.2014.10.015. Epub 2014 Nov 6.

13.

Modular analysis of peripheral blood gene expression in rheumatoid arthritis captures reproducible gene expression changes in tumor necrosis factor responders.

Oswald M, Curran ME, Lamberth SL, Townsend RM, Hamilton JD, Chernoff DN, Carulli J, Townsend MJ, Weinblatt ME, Kern M, Pond CM, Lee A, Gregersen PK.

Arthritis Rheumatol. 2015 Feb;67(2):344-51. doi: 10.1002/art.38947.

PMID:
25371395
14.

Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.

Okada Y, Han B, Tsoi LC, Stuart PE, Ellinghaus E, Tejasvi T, Chandran V, Pellett F, Pollock R, Bowcock AM, Krueger GG, Weichenthal M, Voorhees JJ, Rahman P, Gregersen PK, Franke A, Nair RP, Abecasis GR, Gladman DD, Elder JT, de Bakker PI, Raychaudhuri S.

Am J Hum Genet. 2014 Aug 7;95(2):162-72. doi: 10.1016/j.ajhg.2014.07.002. Epub 2014 Jul 31.

15.

Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.

Govind N, Choudhury A, Hodkinson B, Ickinger C, Frost J, Lee A, Gregersen PK, Reynolds RJ, Bridges SL Jr, Hazelhurst S, Ramsay M, Tikly M.

Mol Med. 2014 Aug 14;20:341-9. doi: 10.2119/molmed.2014.00097.

16.

A novel approach to the generation of seamless constructs for plant transformation.

Kronbak R, Ingvardsen CR, Madsen CK, Gregersen PL.

Plant Methods. 2014 May 10;10:10. doi: 10.1186/1746-4811-10-10. eCollection 2014.

17.

Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies.

Jani M, Massey J, Wedderburn LR, Vencovský J, Danko K, Lundberg IE, Padyukov L, Selva-O'Callaghan A, Radstake T, Platt H, Warren RB, Griffiths CE, Lee A, Gregersen PK, Miller FW, Ollier WE, Cooper RG, Chinoy H, Lamb JA; EUMYONET.

Ann Rheum Dis. 2014 Sep;73(9):1750-2. doi: 10.1136/annrheumdis-2014-205440. Epub 2014 May 7. No abstract available.

PMID:
24812289
18.

Identification of predominant genes involved in regulation and execution of senescence-associated nitrogen remobilization in flag leaves of field grown barley.

Hollmann J, Gregersen PL, Krupinska K.

J Exp Bot. 2014 Jul;65(14):3963-73. doi: 10.1093/jxb/eru094. Epub 2014 Apr 3.

19.

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

Han B, Diogo D, Eyre S, Kallberg H, Zhernakova A, Bowes J, Padyukov L, Okada Y, González-Gay MA, Rantapää-Dahlqvist S, Martin J, Huizinga TW, Plenge RM, Worthington J, Gregersen PK, Klareskog L, de Bakker PI, Raychaudhuri S.

Am J Hum Genet. 2014 Apr 3;94(4):522-32. doi: 10.1016/j.ajhg.2014.02.013. Epub 2014 Mar 20.

20.

Editorial: the power of a modular approach to transcriptional analysis.

Gregersen PK, Oswald M.

Arthritis Rheumatol. 2014 Jun;66(6):1418-20. doi: 10.1002/art.38629. No abstract available.

PMID:
24644035
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