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Results: 1 to 20 of 184

1.

Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling.

Hutchinson KR, Saripalli C, Chung CS, Granzier H.

J Mol Cell Cardiol. 2015 Feb;79:104-14. doi: 10.1016/j.yjmcc.2014.10.020. Epub 2014 Nov 8.

PMID:
25450617
[PubMed - in process]
2.

Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function.

Granzier HL, Hutchinson KR, Tonino P, Methawasin M, Li FW, Slater RE, Bull MM, Saripalli C, Pappas CT, Gregorio CC, Smith JE 3rd.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14589-94. doi: 10.1073/pnas.1411493111. Epub 2014 Sep 22.

PMID:
25246556
[PubMed - in process]
Free PMC Article
3.

Tissue triage and freezing for models of skeletal muscle disease.

Meng H, Janssen PM, Grange RW, Yang L, Beggs AH, Swanson LC, Cossette SA, Frase A, Childers MK, Granzier H, Gussoni E, Lawlor MW.

J Vis Exp. 2014 Jul 15;(89). doi: 10.3791/51586.

PMID:
25078247
[PubMed - in process]
Free PMC Article
4.

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.

Elhamine F, Radke MH, Pfitzer G, Granzier H, Gotthardt M, Stehle R.

J Cell Sci. 2014 Sep 1;127(Pt 17):3666-74. doi: 10.1242/jcs.141796. Epub 2014 Jun 30.

PMID:
24982444
[PubMed - in process]
5.

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension.

Rain S, Bos Dda S, Handoko ML, Westerhof N, Stienen G, Ottenheijm C, Goebel M, Dorfm├╝ller P, Guignabert C, Humbert M, Bogaard HJ, Remedios CD, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, van der Velden J, de Man FS.

J Am Heart Assoc. 2014 Jun 3;3(3):e000716. doi: 10.1161/JAHA.113.000716.

PMID:
24895160
[PubMed - in process]
Free Article
6.

Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice.

Hidalgo C, Saripalli C, Granzier HL.

Arch Biochem Biophys. 2014 Jun 15;552-553:100-7. doi: 10.1016/j.abb.2014.02.010. Epub 2014 Mar 3.

PMID:
24603287
[PubMed - indexed for MEDLINE]
7.

Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.

Methawasin M, Hutchinson KR, Lee EJ, Smith JE 3rd, Saripalli C, Hidalgo CG, Ottenheijm CA, Granzier H.

Circulation. 2014 May 13;129(19):1924-36. doi: 10.1161/CIRCULATIONAHA.113.005610. Epub 2014 Mar 5.

PMID:
24599837
[PubMed - indexed for MEDLINE]
8.

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.

Buck D, Smith JE 3rd, Chung CS, Ono Y, Sorimachi H, Labeit S, Granzier HL.

J Gen Physiol. 2014 Feb;143(2):215-30. doi: 10.1085/jgp.201311129.

PMID:
24470489
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Cardiac titin and heart disease.

LeWinter MM, Granzier HL.

J Cardiovasc Pharmacol. 2014 Mar;63(3):207-12. doi: 10.1097/FJC.0000000000000007. Review.

PMID:
24072177
[PubMed - indexed for MEDLINE]
10.

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension.

Rain S, Handoko ML, Trip P, Gan CT, Westerhof N, Stienen GJ, Paulus WJ, Ottenheijm CA, Marcus JT, Dorfm├╝ller P, Guignabert C, Humbert M, Macdonald P, Dos Remedios C, Postmus PE, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, van der Velden J, de Man FS.

Circulation. 2013 Oct 29;128(18):2016-25, 1-10. doi: 10.1161/CIRCULATIONAHA.113.001873. Epub 2013 Sep 20.

PMID:
24056688
[PubMed - indexed for MEDLINE]
Free Article
11.

Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy.

Ceyhan-Birsoy O, Agrawal PB, Hidalgo C, Schmitz-Abe K, DeChene ET, Swanson LC, Soemedi R, Vasli N, Iannaccone ST, Shieh PB, Shur N, Dennison JM, Lawlor MW, Laporte J, Markianos K, Fairbrother WG, Granzier H, Beggs AH.

Neurology. 2013 Oct 1;81(14):1205-14. doi: 10.1212/WNL.0b013e3182a6ca62. Epub 2013 Aug 23.

PMID:
23975875
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.

Ottenheijm CA, Buck D, de Winter JM, Ferrara C, Piroddi N, Tesi C, Jasper JR, Malik FI, Meng H, Stienen GJ, Beggs AH, Labeit S, Poggesi C, Lawlor MW, Granzier H.

Brain. 2013 Jun;136(Pt 6):1718-31. doi: 10.1093/brain/awt113. Epub 2013 May 28.

PMID:
23715096
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.

Chung CS, Hutchinson KR, Methawasin M, Saripalli C, Smith JE 3rd, Hidalgo CG, Luo X, Labeit S, Guo C, Granzier HL.

Circulation. 2013 Jul 2;128(1):19-28. doi: 10.1161/CIRCULATIONAHA.112.001268. Epub 2013 May 24.

PMID:
23709671
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations.

de Winter JM, Buck D, Hidalgo C, Jasper JR, Malik FI, Clarke NF, Stienen GJ, Lawlor MW, Beggs AH, Ottenheijm CA, Granzier H.

J Med Genet. 2013 Jun;50(6):383-92. doi: 10.1136/jmedgenet-2012-101470. Epub 2013 Apr 9.

PMID:
23572184
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Titin is a major human disease gene.

LeWinter MM, Granzier HL.

Circulation. 2013 Feb 26;127(8):938-44. doi: 10.1161/CIRCULATIONAHA.112.139717. Review. No abstract available.

PMID:
23439446
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency.

Lee EJ, De Winter JM, Buck D, Jasper JR, Malik FI, Labeit S, Ottenheijm CA, Granzier H.

PLoS One. 2013;8(2):e55861. doi: 10.1371/journal.pone.0055861. Epub 2013 Feb 20.

PMID:
23437068
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.

Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen GJ, Granzier H, Labeit S, Ottenheijm CA, Bendahan D, Gondin J.

Neuromuscul Disord. 2013 Apr;23(4):357-69. doi: 10.1016/j.nmd.2012.12.011. Epub 2013 Feb 1.

PMID:
23375831
[PubMed - indexed for MEDLINE]
18.

Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy.

Lassche S, Stienen GJ, Irving TC, van der Maarel SM, Voermans NC, Padberg GW, Granzier H, van Engelen BG, Ottenheijm CA.

Neurology. 2013 Feb 19;80(8):733-7. doi: 10.1212/WNL.0b013e318282513b. Epub 2013 Jan 30.

PMID:
23365058
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.

Anderson BR, Bogomolovas J, Labeit S, Granzier H.

J Biol Chem. 2013 Feb 22;288(8):5303-15. doi: 10.1074/jbc.M112.401372. Epub 2013 Jan 6.

PMID:
23297410
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Tuning the molecular giant titin through phosphorylation: role in health and disease.

Hidalgo C, Granzier H.

Trends Cardiovasc Med. 2013 Jul;23(5):165-71. doi: 10.1016/j.tcm.2012.10.005. Epub 2013 Jan 5. Review.

PMID:
23295080
[PubMed - indexed for MEDLINE]
Free PMC Article

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