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Results: 1 to 20 of 62


Bio-analytical method based on MALDI-MS analysis for the quantification of CIGB-300 anti-tumor peptide in human plasma.

Cabrales-Rico A, de la Torre BG, Garay HE, Machado YJ, Gómez JA, Audain E, Morales O, Besada V, Marcelo JL, Reyes V, Perera Y, Perea SE, Reyes O, González LJ.

J Pharm Biomed Anal. 2015 Feb;105:107-14. doi: 10.1016/j.jpba.2014.11.043. Epub 2014 Dec 3.


Host-specific enzyme-substrate interactions in SPM-1 metallo-β-lactamase are modulated by second sphere residues.

González LJ, Moreno DM, Bonomo RA, Vila AJ.

PLoS Pathog. 2014 Jan;10(1):e1003817. doi: 10.1371/journal.ppat.1003817. Epub 2014 Jan 2.


Characterization of protein complexes using targeted proteomics.

Gomez YR, Gallien S, Huerta V, van Oostrum J, Domon B, Gonzalez LJ.

Curr Top Med Chem. 2014;14(3):344-50. Review.


Antibiotic resistance in Zn(II)-deficient environments: metallo-β-lactamase activation in the periplasm.

Meini MR, González LJ, Vila AJ.

Future Microbiol. 2013 Aug;8(8):947-79. doi: 10.2217/fmb.13.34. No abstract available.


SCX charge state selective separation of tryptic peptides combined with 2D-RP-HPLC allows for detailed proteome mapping.

Betancourt LH, De Bock PJ, Staes A, Timmerman E, Perez-Riverol Y, Sanchez A, Besada V, Gonzalez LJ, Vandekerckhove J, Gevaert K.

J Proteomics. 2013 Oct 8;91:164-71. doi: 10.1016/j.jprot.2013.06.033. Epub 2013 Jul 11.


HI-bone: a scoring system for identifying phenylisothiocyanate-derivatized peptides based on precursor mass and high intensity fragment ions.

Perez-Riverol Y, Sánchez A, Noda J, Borges D, Carvalho PC, Wang R, Vizcaíno JA, Betancourt L, Ramos Y, Duarte G, Nogueira FC, González LJ, Padrón G, Tabb DL, Hermjakob H, Domont GB, Besada V.

Anal Chem. 2013 Apr 2;85(7):3515-20. doi: 10.1021/ac303239g. Epub 2013 Mar 20.


Computational proteomics pitfalls and challenges: HavanaBioinfo 2012 workshop report.

Perez-Riverol Y, Hermjakob H, Kohlbacher O, Martens L, Creasy D, Cox J, Leprevost F, Shan BP, Pérez-Nueno VI, Blazejczyk M, Punta M, Vierlinger K, Valiente PA, Leon K, Chinea G, Guirola O, Bringas R, Cabrera G, Guillen G, Padron G, Gonzalez LJ, Besada V.

J Proteomics. 2013 Jul 11;87:134-8. doi: 10.1016/j.jprot.2013.01.019. Epub 2013 Jan 29.


Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers.

Cabrales A, Gil J, Fernández E, Valenzuela C, Hernández F, García I, Hernández A, Besada V, Reyes O, Padrón G, Berlanga J, Guillén G, González LJ.

Eur J Pharm Sci. 2013 Jan 23;48(1-2):40-6. doi: 10.1016/j.ejps.2012.10.006. Epub 2012 Oct 23.


Periplasmic proteins encoded by VCA0261-0260 and VC2216 genes together with copA and cueR products are required for copper tolerance but not for virulence in Vibrio cholerae.

Marrero K, Sánchez A, González LJ, Ledón T, Rodríguez-Ulloa A, Castellanos-Serra L, Pérez C, Fando R.

Microbiology. 2012 Aug;158(Pt 8):2005-16. doi: 10.1099/mic.0.059345-0. Epub 2012 May 31.


Isoelectric point optimization using peptide descriptors and support vector machines.

Perez-Riverol Y, Audain E, Millan A, Ramos Y, Sanchez A, Vizcaíno JA, Wang R, Müller M, Machado YJ, Betancourt LH, González LJ, Padrón G, Besada V.

J Proteomics. 2012 Apr 3;75(7):2269-74. doi: 10.1016/j.jprot.2012.01.029. Epub 2012 Feb 3.


Carbapenem resistance in Elizabethkingia meningoseptica is mediated by metallo-β-lactamase BlaB.

González LJ, Vila AJ.

Antimicrob Agents Chemother. 2012 Apr;56(4):1686-92. doi: 10.1128/AAC.05835-11. Epub 2012 Jan 30.


Introducing an Asp-Pro linker in the synthesis of random one-bead-one-compound hexapeptide libraries compatible with ESI-MS analysis.

Masforrol Y, Gil J, González LJ, Pérez-Riverol Y, Fernández-de-Cossío J, Sánchez A, Betancourt LH, Garay HE, Cabrales A, Albericio F, Yang H, Zubarev RA, Besada V, Acosta OR.

ACS Comb Sci. 2012 Mar 12;14(3):145-9. doi: 10.1021/co200159r. Epub 2012 Feb 28.


Selective isolation of multiply charged peptides: a confident strategy for protein identification using a linear trap quadrupole mass spectrometer.

Sanchez A, Sun W, Ma J, Betancourt L, Perez-Riverol Y, de-Cossio JF, Padron G, Jiang Y, He F, Gonzalez LJ, Besada V.

Eur J Mass Spectrom (Chichester, Eng). 2012;18(6):505-8.


Development and validation of a bioanalytical LC-MS method for the quantification of GHRP-6 in human plasma.

Gil J, Cabrales A, Reyes O, Morera V, Betancourt L, Sánchez A, García G, Moya G, Padrón G, Besada V, González LJ.

J Pharm Biomed Anal. 2012 Feb 23;60:19-25. doi: 10.1016/j.jpba.2011.11.007. Epub 2011 Nov 15.


CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research.

Perea SE, Baladron I, Garcia Y, Perera Y, Lopez A, Soriano JL, Batista N, Palau A, Hernández I, Farina H, Garcia I, Gonzalez L, Gil J, Rodriguez A, Solares M, Santana A, Cruz M, Lopez M, Valenzuela C, Reyes O, López-Saura PA, González CA, Diaz A, Castellanos L, Sanchez A, Betancourt L, Besada V, González LJ, Garay H, Gómez R, Gómez DE, Alonso DF, Perrin P, Renualt JY, Sigman H, Herrera L, Acevedo B.

Mol Cell Biochem. 2011 Oct;356(1-2):45-50. doi: 10.1007/s11010-011-0950-y. Epub 2011 Jul 7.


In silico analysis of accurate proteomics, complemented by selective isolation of peptides.

Perez-Riverol Y, Sánchez A, Ramos Y, Schmidt A, Müller M, Betancourt L, González LJ, Vera R, Padron G, Besada V.

J Proteomics. 2011 Sep 6;74(10):2071-82. doi: 10.1016/j.jprot.2011.05.034. Epub 2011 May 27.


Charge state-selective separation of peptides by reversible modification of amino groups and strong cation-exchange chromatography: evaluation in proteomic studies using peptide-centric database searches.

Betancourt LH, Sánchez A, Pérez Y, Fernandez de Cossio J, Gil J, Toledo P, Iguchi S, Aimoto S, González LJ, Padrón G, Takao T, Besada V.

J Proteomics. 2011 Sep 6;74(10):2210-3. doi: 10.1016/j.jprot.2011.04.029. Epub 2011 May 9.


Peptide fractionation by acid pH SDS-free electrophoresis.

Ramos Y, Garcia Y, Pérez-Riverol Y, Leyva A, Padrón G, Sánchez A, Castellanos-Serra L, González LJ, Besada V.

Electrophoresis. 2011 Jun;32(11):1323-6. doi: 10.1002/elps.201000677. Epub 2011 May 2.


[Risk analysis of foodborne diseases: microbial risk assessment].

González LJ, Martínez FN, Rossi L, Tornese M, Troncoso A.

Rev Chilena Infectol. 2010 Dec;27(6):513-24. doi: /S0716-10182010000700004. Epub 2011 Jan 7. Review. Spanish.


Selective isolation-detection of two different positively charged peptides groups by strong cation exchange chromatography and matrix-assisted laser desorption/ionization mass spectrometry: application to proteomics studies.

Sanchez A, Sun W, Wang L, Ma J, Betancourt L, Gil J, Perez-Riverol Y, Fernandez de-Cossio J, Padron G, Jiang Y, He F, Gonzalez LJ, Besada V.

Eur J Mass Spectrom (Chichester, Eng). 2010;16(6):693-702. doi: 10.1255/ejms.1105.

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