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Results: 1 to 20 of 177


Emerging targets in osteoarthritis therapy.

Goldring MB, Berenbaum F.

Curr Opin Pharmacol. 2015 Apr 9;22:51-63. doi: 10.1016/j.coph.2015.03.004. [Epub ahead of print] Review.


Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.

Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB.

Arthritis Res Ther. 2014 Dec 17;16(6):508. doi: 10.1186/s13075-014-0508-y.


Mouse models of osteoarthritis: surgical model of posttraumatic osteoarthritis induced by destabilization of the medial meniscus.

Culley KL, Dragomir CL, Chang J, Wondimu EB, Coico J, Plumb DA, Otero M, Goldring MB.

Methods Mol Biol. 2015;1226:143-73. doi: 10.1007/978-1-4939-1619-1_12.


Mechanical forces induce changes in VEGF and VEGFR-1/sFlt-1 expression in human chondrocytes.

Beckmann R, Houben A, Tohidnezhad M, Kweider N, Fragoulis A, Wruck CJ, Brandenburg LO, Hermanns-Sachweh B, Goldring MB, Pufe T, Jahr H.

Int J Mol Sci. 2014 Sep 1;15(9):15456-74. doi: 10.3390/ijms150915456.


Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation.

Imagawa K, de Andrés MC, Hashimoto K, Itoi E, Otero M, Roach HI, Goldring MB, Oreffo RO.

Arthritis Rheumatol. 2014 Nov;66(11):3040-51. doi: 10.1002/art.38774.


A hyaluronic acid-salmon calcitonin conjugate for the local treatment of osteoarthritis: chondro-protective effect in a rabbit model of early OA.

Mero A, Campisi M, Favero M, Barbera C, Secchieri C, Dayer JM, Goldring MB, Goldring SR, Pasut G.

J Control Release. 2014 Aug 10;187:30-8. doi: 10.1016/j.jconrel.2014.05.008. Epub 2014 May 15.


Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis.

Wang S, Wei X, Zhou J, Zhang J, Li K, Chen Q, Terek R, Fleming BC, Goldring MB, Ehrlich MG, Zhang G, Wei L.

Arthritis Rheumatol. 2014 Jul;66(7):1843-53. doi: 10.1002/art.38576.


Biochemical evidence for gap junctions and Cx43 expression in immortalized human chondrocyte cell line: a potential model in the study of cell communication in human chondrocytes.

Gago-Fuentes R, Carpintero-Fernandez P, Goldring MB, Brink PR, Mayan MD, Blanco FJ.

Osteoarthritis Cartilage. 2014 Apr;22(4):586-90. doi: 10.1016/j.joca.2014.02.002. Epub 2014 Feb 14.


Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction.

Zhao R, Wang A, Hall KC, Otero M, Weskamp G, Zhao B, Hill D, Goldring MB, Glomski K, Blobel CP.

J Orthop Res. 2014 Feb;32(2):224-30. doi: 10.1002/jor.22492. Epub 2013 Sep 21.


Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis.

Houard X, Goldring MB, Berenbaum F.

Curr Rheumatol Rep. 2013 Nov;15(11):375. doi: 10.1007/s11926-013-0375-6. Review.


IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation.

Olivotto E, Otero M, Astolfi A, Platano D, Facchini A, Pagani S, Flamigni F, Facchini A, Goldring MB, Borzì RM, Marcu KB.

PLoS One. 2013 Sep 2;8(9):e73024. doi: 10.1371/journal.pone.0073024. eCollection 2013.


Oxidative stress and status of antioxidant enzymes in children with Kashin-Beck disease.

Wang W, Wei S, Luo M, Yu B, Cao J, Yang Z, Wang Z, Goldring MB, Chen J.

Osteoarthritis Cartilage. 2013 Nov;21(11):1781-9. doi: 10.1016/j.joca.2013.08.002. Epub 2013 Aug 12.


Pulsed electromagnetic fields increased the anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts.

Vincenzi F, Targa M, Corciulo C, Gessi S, Merighi S, Setti S, Cadossi R, Goldring MB, Borea PA, Varani K.

PLoS One. 2013 May 31;8(5):e65561. doi: 10.1371/journal.pone.0065561. Print 2013.


ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.

Hall KC, Hill D, Otero M, Plumb DA, Froemel D, Dragomir CL, Maretzky T, Boskey A, Crawford HC, Selleri L, Goldring MB, Blobel CP.

Mol Cell Biol. 2013 Aug;33(16):3077-90. doi: 10.1128/MCB.00291-13. Epub 2013 Jun 3.


Insight into the function of DIO2, a susceptibility gene in human osteoarthritis, as an inducer of cartilage damage in a rat model: is there a role for chondrocyte hypertrophy?

Goldring MB.

Osteoarthritis Cartilage. 2013 May;21(5):643-5. doi: 10.1016/j.joca.2013.02.659. Epub 2013 Mar 6. No abstract available.


In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae.

Ko FC, Dragomir C, Plumb DA, Goldring SR, Wright TM, Goldring MB, van der Meulen MC.

Arthritis Rheum. 2013 Jun;65(6):1569-78. doi: 10.1002/art.37906.


Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.

Hashimoto K, Otero M, Imagawa K, de Andrés MC, Coico JM, Roach HI, Oreffo RO, Marcu KB, Goldring MB.

J Biol Chem. 2013 Apr 5;288(14):10061-72. doi: 10.1074/jbc.M112.421156. Epub 2013 Feb 15.


Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues.

Ritter SY, Subbaiah R, Bebek G, Crish J, Scanzello CR, Krastins B, Sarracino D, Lopez MF, Crow MK, Aigner T, Goldring MB, Goldring SR, Lee DM, Gobezie R, Aliprantis AO.

Arthritis Rheum. 2013 Apr;65(4):981-92. doi: 10.1002/art.37823.


Articular cartilage degradation in osteoarthritis.

Goldring MB.

HSS J. 2012 Feb;8(1):7-9. doi: 10.1007/s11420-011-9250-z. Epub 2012 Jan 24. No abstract available.


Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes.

de Andrés MC, Imagawa K, Hashimoto K, Gonzalez A, Roach HI, Goldring MB, Oreffo RO.

Arthritis Rheum. 2013 Mar;65(3):732-42. doi: 10.1002/art.37806.

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