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Results: 1 to 20 of 41

1.

Novel type of plasmin inhibitors: providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine.

Teno N, Gohda K, Wanaka K, Tsuda Y, Akagawa M, Akiduki E, Araki M, Masuda A, Otsubo T, Yamashita Y.

Bioorg Med Chem. 2015 Jul 1;23(13):3696-704. doi: 10.1016/j.bmc.2015.04.013. Epub 2015 Apr 10.

PMID:
25921265
2.

Detection and preliminary evaluation of circulating tumor cells in the peripheral blood of patients with eight types of cancer using a telomerase-specific adenovirus.

Yabusaki M, Sato J, Kohyama A, Kojima T, Nobuoka D, Yoshikawa T, Sawada Y, Murakami K, Gohda K, Okegawa T, Nakamura M, Takamatsu K, Ito M, Kaneko K, Nakatsura T.

Oncol Rep. 2014 Nov;32(5):1772-8. doi: 10.3892/or.2014.3436. Epub 2014 Aug 22.

3.

Prognostic impact of the number of viable circulating cells with high telomerase activity in gastric cancer patients: a prospective study.

Ito H, Inoue H, Kimura S, Ohmori T, Ishikawa F, Gohda K, Sato J.

Int J Oncol. 2014 Jul;45(1):227-34. doi: 10.3892/ijo.2014.2409. Epub 2014 Apr 29.

PMID:
24788213
4.

Circulating tumor cells as a prognostic factor in patients with small cell lung cancer.

Igawa S, Gohda K, Fukui T, Ryuge S, Otani S, Masago A, Sato J, Murakami K, Maki S, Katono K, Takakura A, Sasaki J, Satoh Y, Masuda N.

Oncol Lett. 2014 May;7(5):1469-1473. Epub 2014 Mar 5.

5.

Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin.

Teno N, Gohda K, Wanaka K, Tsuda Y, Sueda T, Yamashita Y, Otsubo T.

Bioorg Med Chem. 2014 Apr 1;22(7):2339-52. doi: 10.1016/j.bmc.2014.02.002. Epub 2014 Feb 24.

PMID:
24613052
6.

Novel functional assay for spindle-assembly checkpoint by cyclin-dependent kinase activity to predict taxane chemosensitivity in breast tumor patient.

Torikoshi Y, Gohda K, Davis ML, Symmans WF, Pusztai L, Kazansky A, Nakayama S, Yoshida T, Matsushima T, Hortobagyi GN, Ishihara H, Kim SJ, Noguchi S, Ueno NT.

J Cancer. 2013 Nov 14;4(9):697-702. doi: 10.7150/jca.6248. eCollection 2013.

7.

Synthetic substrates specific to activated plasmin can monitor the enzymatic functional status in situ in breast cancer cells.

Gohda K, Fujimori K, Teno N, Wanaka K, Tsuda Y.

Chem Biol Drug Des. 2014 Jan;83(1):52-7. doi: 10.1111/cbdd.12232. Epub 2013 Oct 30.

PMID:
24112688
8.

Synthesis and evaluation of tripeptidic plasmin inhibitors with nitrile as warhead.

Teno N, Otsubo T, Gohda K, Wanaka K, Sueda T, Ikeda K, Hijikata-Okunomiya A, Tsuda Y.

J Pept Sci. 2012 Oct;18(10):620-5. doi: 10.1002/psc.2442. Epub 2012 Sep 7.

PMID:
22961872
9.

Prognostic impact of detecting viable circulating tumour cells in gastric cancer patients using a telomerase-specific viral agent: a prospective study.

Ito H, Inoue H, Sando N, Kimura S, Gohda K, Sato J, Murakami K, Ito S, Odaka N, Satodate H, Kudo SE.

BMC Cancer. 2012 Aug 9;12:346. doi: 10.1186/1471-2407-12-346.

10.

Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer.

Zeestraten EC, Maak M, Shibayama M, Schuster T, Nitsche U, Matsushima T, Nakayama S, Gohda K, Friess H, van de Velde CJ, Ishihara H, Rosenberg R, Kuppen PJ, Janssen KP.

Br J Cancer. 2012 Jan 3;106(1):133-40. doi: 10.1038/bjc.2011.504. Epub 2011 Nov 22. Erratum in: Br J Cancer. 2012 Feb 14;106(4):792.

11.

Predicting subsite interactions of plasmin with substrates and inhibitors through computational docking analysis.

Gohda K, Teno N, Wanaka K, Tsuda Y.

J Enzyme Inhib Med Chem. 2012 Aug;27(4):571-7. doi: 10.3109/14756366.2011.603129. Epub 2011 Oct 12.

PMID:
21992704
12.

Identification of novel plasmin inhibitors possessing nitrile moiety as warhead.

Teno N, Gohda K, Wanaka K, Sueda T, Tsuda Y.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6305-9. doi: 10.1016/j.bmcl.2011.08.121. Epub 2011 Sep 1.

PMID:
21944858
13.

Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells.

Nakayama S, Torikoshi Y, Takahashi T, Yoshida T, Sudo T, Matsushima T, Kawasaki Y, Katayama A, Gohda K, Hortobagyi GN, Noguchi S, Sakai T, Ishihara H, Ueno NT.

Breast Cancer Res. 2009;11(1):R12. doi: 10.1186/bcr2231. Epub 2009 Feb 24.

14.

Validation study of the prognostic value of cyclin-dependent kinase (CDK)-based risk in Caucasian breast cancer patients.

van Nes JG, Smit VT, Putter H, Kuppen PJ, Kim SJ, Daito M, Ding J, Shibayama M, Numada S, Gohda K, Matsushima T, Ishihara H, Noguchi S, van de Velde CJ.

Br J Cancer. 2009 Feb 10;100(3):494-500. doi: 10.1038/sj.bjc.6604870. Epub 2009 Jan 20.

15.

Species differences between human and rat in the substrate specificity of cathepsin K.

Tada S, Tsutsumi K, Ishihara H, Suzuki K, Gohda K, Teno N.

J Biochem. 2008 Oct;144(4):499-506. doi: 10.1093/jb/mvn093. Epub 2008 Jul 29.

PMID:
18664521
16.

A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation.

Gohda K, Hakoshima T.

J Comput Aided Mol Des. 2008 Nov;22(11):789-97. doi: 10.1007/s10822-008-9214-7. Epub 2008 Apr 15.

PMID:
18415022
17.

New chemotypes for cathepsin K inhibitors.

Teno N, Irie O, Miyake T, Gohda K, Horiuchi M, Tada S, Nonomura K, Kometani M, Iwasaki G, Betschart C.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2599-603. doi: 10.1016/j.bmcl.2008.03.036. Epub 2008 Mar 16.

PMID:
18375120
18.

Novel scaffold for cathepsin K inhibitors.

Teno N, Miyake T, Ehara T, Irie O, Sakaki J, Ohmori O, Gunji H, Matsuura N, Masuya K, Hitomi Y, Nonomura K, Horiuchi M, Gohda K, Iwasaki A, Umemura I, Tada S, Kometani M, Iwasaki G, Cowan-Jacob SW, Missbach M, Lattmann R, Betschart C.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6096-100. Epub 2007 Sep 15.

PMID:
17911019
19.

NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity.

Shimamoto S, Yoshida T, Inui T, Gohda K, Kobayashi Y, Fujimori K, Tsurumura T, Aritake K, Urade Y, Ohkubo T.

J Biol Chem. 2007 Oct 26;282(43):31373-9. Epub 2007 Aug 22. Erratum in: J Biol Chem. 2008 Mar 28;283(13):8772.

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