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Phenotyping of UGT1A1 Activity Using Raltegravir Predicts Pharmacokinetics and Toxicity of Irinotecan in FOLFIRI.

Lee LS, Seng KY, Wang LZ, Yong WP, Hee KH, Soh TI, Wong A, Cheong PF, Soong R, Sapari NS, Soo R, Fan L, Lee SC, Goh BC.

PLoS One. 2016 Jan 25;11(1):e0147681. doi: 10.1371/journal.pone.0147681. eCollection 2016.


Dose Modifications in Asian Cancer Patients with Hepatic Dysfunction Receiving Weekly Docetaxel: A Prospective Pharmacokinetics and Safety Study.

Syn NL, Wang L, Wong AL, Soe MY, Chuah B, Chan D, Tan SH, Soo RA, Lee SC, Goh BC, Yong WP.

Cancer Sci. 2015 Dec 12. doi: 10.1111/cas.12856. [Epub ahead of print]


Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model.

Zhang J, Ahn KS, Kim C, Shanmugam MK, Siveen KS, Arfuso F, Samy RP, Deivasigamani A, Lim LH, Wang L, Goh BC, Kumar AP, Hui KM, Sethi G.

Antioxid Redox Signal. 2015 Dec 9. [Epub ahead of print]


Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway.

Wang T, Seah S, Loh X, Chan CW, Hartman M, Goh BC, Lee SC.

Oncotarget. 2015 Nov 11. doi: 10.18632/oncotarget.6304. [Epub ahead of print]


Genetic factors affecting drug disposition in Asian cancer patients.

Syn NL, Yong WP, Lee SC, Goh BC.

Expert Opin Drug Metab Toxicol. 2015 Dec;11(12):1879-92. doi: 10.1517/17425255.2015.1108964. Epub 2015 Nov 7.


UGT1A1 Mediated Drug Interactions and its Clinical Relevance.

Goon CP, Wang LZ, Wong FC, Thuya WL, Ho PC, Goh BC.

Curr Drug Metab. 2016;17(2):100-6.


Targeting transcription factor STAT3 for cancer prevention and therapy.

Chai EZ, Shanmugam MK, Arfuso F, Dharmarajan A, Wang C, Kumar AP, Samy RP, Lim LH, Wang L, Goh BC, Ahn KS, Hui KM, Sethi G.

Pharmacol Ther. 2015 Oct 20. pii: S0163-7258(15)00185-0. doi: 10.1016/j.pharmthera.2015.10.004. [Epub ahead of print] Review.


Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide.

Kang J, Chong SJ, Ooi VZ, Vali S, Kumar A, Kapoor S, Abbasi T, Hirpara JL, Loh T, Goh BC, Pervaiz S.

Oncotarget. 2015 Oct 27;6(33):34191-205. doi: 10.18632/oncotarget.5763.


Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma.

Chua KN, Kong LR, Sim WJ, Ng HC, Ong WR, Thiery JP, Huynh H, Goh BC.

Oncotarget. 2015 Oct 6;6(30):29991-30005. doi: 10.18632/oncotarget.5031.


68 Ga-DOTA-peptide: A novel molecular biomarker for nasopharyngeal carcinoma.

Khor LK, Loi HY, Sinha AK, Tong KT, Goh BC, Loh KS, Lu SJ.

Head Neck. 2015 Aug 14. doi: 10.1002/hed.24164. [Epub ahead of print]


Pharmacogenetic versus clinical dosing of warfarin in individuals of Chinese and African-American ancestry: assessment using data simulation.

Syn NL, Lee SC, Brunham LR, Goh BC.

Pharmacogenet Genomics. 2015 Oct;25(10):491-500. doi: 10.1097/FPC.0000000000000165.


Dysregulated TGF-β signaling alters bone microstructure in a mouse model of Loeys-Dietz syndrome.

Dewan AK, Tomlinson RE, Mitchell S, Goh BC, Yung RM, Kumar S, Tan EW, Faugere MC, Dietz HC 3rd, Clemens TL, Sponseller PD.

J Orthop Res. 2015 Oct;33(10):1447-54. doi: 10.1002/jor.22920. Epub 2015 Jul 14.


Atomic Modeling of an Immature Retroviral Lattice Using Molecular Dynamics and Mutagenesis.

Goh BC, Perilla JR, England MR, Heyrana KJ, Craven RC, Schulten K.

Structure. 2015 Aug 4;23(8):1414-25. doi: 10.1016/j.str.2015.05.017. Epub 2015 Jun 25.


Multicenter phase II study of the AKT inhibitor MK-2206 in recurrent or metastatic nasopharyngeal carcinoma from patients in the mayo phase II consortium and the cancer therapeutics research group (MC1079).

Ma BB, Goh BC, Lim WT, Hui EP, Tan EH, Lopes Gde L, Lo KW, Li L, Loong H, Foster NR, Erlichman C, King AD, Kam MK, Leung SF, Chan KC, Chan AT.

Invest New Drugs. 2015 Aug;33(4):985-91. doi: 10.1007/s10637-015-0264-0. Epub 2015 Jun 19.


Clinical Outcome among Nasopharyngeal Cancer Patients in a Multi-Ethnic Society in Singapore.

Mak HW, Lee SH, Chee J, Tham I, Goh BC, Chao SS, Ong YK, Loh KS, Lim CM.

PLoS One. 2015 May 12;10(5):e0126108. doi: 10.1371/journal.pone.0126108. eCollection 2015.


MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma.

Kong LR, Chua KN, Sim WJ, Ng HC, Bi C, Ho J, Nga ME, Pang YH, Ong WR, Soo RA, Huynh H, Chng WJ, Thiery JP, Goh BC.

Mol Cancer Ther. 2015 Jul;14(7):1750-60. doi: 10.1158/1535-7163.MCT-15-0062. Epub 2015 May 4.


Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.

Wong AL, Lim JS, Sinha A, Gopinathan A, Lim R, Tan CS, Soh T, Venkatesh S, Titin C, Sapari NS, Lee SC, Yong WP, Tan DS, Pang B, Wang TT, Zee YK, Soong R, Trnkova Z, Lathia C, Thiery JP, Wilhelm S, Jeffers M, Goh BC.

J Transl Med. 2015 Feb 12;13:57. doi: 10.1186/s12967-015-0405-4.


Molecular dynamics simulations of large macromolecular complexes.

Perilla JR, Goh BC, Cassidy CK, Liu B, Bernardi RC, Rudack T, Yu H, Wu Z, Schulten K.

Curr Opin Struct Biol. 2015 Apr;31:64-74. doi: 10.1016/ Epub 2015 Apr 4. Review.


Garcinol: Current status of its anti-oxidative, anti-inflammatory and anti-cancer effects.

Liu C, Ho PC, Wong FC, Sethi G, Wang LZ, Goh BC.

Cancer Lett. 2015 Jun 28;362(1):8-14. doi: 10.1016/j.canlet.2015.03.019. Epub 2015 Mar 18. Review.


Validation of a rapid and sensitive LC-MS/MS method for determination of exemestane and its metabolites, 17β-hydroxyexemestane and 17β-hydroxyexemestane-17-O-β-D-glucuronide: application to human pharmacokinetics study.

Wang LZ, Goh SH, Wong AL, Thuya WL, Lau JY, Wan SC, Lee SC, Ho PC, Goh BC.

PLoS One. 2015 Mar 20;10(3):e0118553. doi: 10.1371/journal.pone.0118553. eCollection 2015.

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