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Results: 1 to 20 of 38

1.

Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.

Goglia AG, Delsite R, Luz AN, Shahbazian D, Salem AF, Sundaram RK, Chiaravalli J, Hendrikx PJ, Wilshire JA, Jasin M, Kluger HM, Glickman JF, Powell SN, Bindra RS.

Mol Cancer Ther. 2015 Feb;14(2):326-42. doi: 10.1158/1535-7163.MCT-14-0765. Epub 2014 Dec 15.

PMID:
25512618
2.

Controversies in ASSAY and drug development technologies: a focus on assessing irreproducibility.

Glickman JF, Lundbäck T, Napper AD, Niles WD, Simeonov A, Weaver CD, Yin HH, Zaman GJ, Osada H.

Assay Drug Dev Technol. 2014 Oct;12(8):443-51. doi: 10.1089/adt.2014.1501.

PMID:
25383720
3.

A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice.

Ahn HJ, Glickman JF, Poon KL, Zamolodchikov D, Jno-Charles OC, Norris EH, Strickland S.

J Exp Med. 2014 Jun 2;211(6):1049-62. doi: 10.1084/jem.20131751. Epub 2014 May 12.

4.

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.

Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD.

Nat Chem Biol. 2013 Apr;9(4):247-9. doi: 10.1038/nchembio.1184. Epub 2013 Feb 17.

5.

MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.

Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A.

Cancer Cell. 2012 Dec 11;22(6):812-24. doi: 10.1016/j.ccr.2012.11.003.

6.

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.

Gold B, Pingle M, Brickner SJ, Shah N, Roberts J, Rundell M, Bracken WC, Warrier T, Somersan S, Venugopal A, Darby C, Jiang X, Warren JD, Fernandez J, Ouerfelli O, Nuermberger EL, Cunningham-Bussel A, Rath P, Chidawanyika T, Deng H, Realubit R, Glickman JF, Nathan CF.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16004-11. doi: 10.1073/pnas.1214188109. Epub 2012 Sep 10.

7.

Assay Development for Protein Kinase Enzymes.

Glickman JF.

In: Sittampalam GS, Gal-Edd N, Arkin M, Auld D, Austin C, Bejcek B, Glicksman M, Inglese J, Lemmon V, Li Z, McGee J, McManus O, Minor L, Napper A, Riss T, Trask OJ, Weidner J, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 01 [updated 2012 Oct 01].

8.

Rapid screening for entry inhibitors of highly pathogenic viruses under low-level biocontainment.

Talekar A, Pessi A, Glickman F, Sengupta U, Briese T, Whitt MA, Mathieu C, Horvat B, Moscona A, Porotto M.

PLoS One. 2012;7(3):e30538. doi: 10.1371/journal.pone.0030538. Epub 2012 Mar 2.

9.

Screening for mevalonate biosynthetic pathway inhibitors using sensitized bacterial strains.

Ferrand S, Tao J, Shen X, McGuire D, Schmid A, Glickman JF, Schopfer U.

J Biomol Screen. 2011 Jul;16(6):637-46. doi: 10.1177/1087057111403927. Epub 2011 May 18.

PMID:
21593486
10.

Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization.

Ahn HJ, Zamolodchikov D, Cortes-Canteli M, Norris EH, Glickman JF, Strickland S.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21812-7. doi: 10.1073/pnas.1010373107. Epub 2010 Nov 22.

11.

Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.

Jahnke W, Rondeau JM, Cotesta S, Marzinzik A, Pellé X, Geiser M, Strauss A, Götte M, Bitsch F, Hemmig R, Henry C, Lehmann S, Glickman JF, Roddy TP, Stout SJ, Green JR.

Nat Chem Biol. 2010 Sep;6(9):660-6. doi: 10.1038/nchembio.421. Epub 2010 Aug 15.

PMID:
20711197
12.

An imaging assay to analyze primary neurons for cellular neurotoxicity.

Götte M, Hofmann G, Michou-Gallani AI, Glickman JF, Wishart W, Gabriel D.

J Neurosci Methods. 2010 Sep 30;192(1):7-16. doi: 10.1016/j.jneumeth.2010.07.003. Epub 2010 Jul 8.

PMID:
20620166
13.

Inhibition of dengue virus polymerase by blocking of the RNA tunnel.

Niyomrattanakit P, Chen YL, Dong H, Yin Z, Qing M, Glickman JF, Lin K, Mueller D, Voshol H, Lim JY, Nilar S, Keller TH, Shi PY.

J Virol. 2010 Jun;84(11):5678-86. doi: 10.1128/JVI.02451-09. Epub 2010 Mar 17.

14.

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.

Yin Z, Chen YL, Kondreddi RR, Chan WL, Wang G, Ng RH, Lim JY, Lee WY, Jeyaraj DA, Niyomrattanakit P, Wen D, Chao A, Glickman JF, Voshol H, Mueller D, Spanka C, Dressler S, Nilar S, Vasudevan SG, Shi PY, Keller TH.

J Med Chem. 2009 Dec 24;52(24):7934-7. doi: 10.1021/jm901044z.

PMID:
20014868
15.

Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.

Thoma G, Baenteli R, Lewis I, Wagner T, Oberer L, Blum W, Glickman F, Streiff MB, Zerwes HG.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6185-8. doi: 10.1016/j.bmcl.2009.09.002. Epub 2009 Sep 6.

PMID:
19783143
16.

Hypothesis-driven screening.

Schopfer U, Engeloch C, Höhn F, Mees H, Leeds J, Glickman F, Scheel G, Ferrand S, Fekkes P, Pfeifer M.

Methods Mol Biol. 2009;575:297-316. doi: 10.1007/978-1-60761-274-2_13.

PMID:
19727621
17.

Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy.

Porotto M, Orefice G, Yokoyama CC, Mungall BA, Realubit R, Sganga ML, Aljofan M, Whitt M, Glickman F, Moscona A.

J Virol. 2009 May;83(10):5148-55. doi: 10.1128/JVI.00164-09. Epub 2009 Mar 4.

18.

Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.

Thoma G, Streiff MB, Kovarik J, Glickman F, Wagner T, Beerli C, Zerwes HG.

J Med Chem. 2008 Dec 25;51(24):7915-20. doi: 10.1021/jm801065q.

PMID:
19053768
19.

Scintillation proximity assays in high-throughput screening.

Glickman JF, Schmid A, Ferrand S.

Assay Drug Dev Technol. 2008 Jun;6(3):433-55. doi: 10.1089/adt.2008.135. Review.

PMID:
18593378
20.
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