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The fetal thymus has a unique genomic copy number profile resulting from physiological T cell receptor gene rearrangement.

Valind A, Haikal C, Klasson ME, Johansson MC, Gullander J, Soller M, Baldetorp B, Gisselsson D.

Sci Rep. 2016 Mar 24;6:23500. doi: 10.1038/srep23500.


Aberrant epigenetic regulation in clear cell sarcoma of the kidney featuring distinct DNA hypermethylation and EZH2 overexpression.

Karlsson J, Valind A, Jansson C, O'Sullivan MJ, Holmquist Mengelbier L, Gisselsson D.

Oncotarget. 2016 Mar 8;7(10):11127-36. doi: 10.18632/oncotarget.7152.


Multiple mechanisms of MYCN dysregulation in Wilms tumour.

Williams RD, Chagtai T, Alcaide-German M, Apps J, Wegert J, Popov S, Vujanic G, van Tinteren H, van den Heuvel-Eibrink MM, Kool M, de Kraker J, Gisselsson D, Graf N, Gessler M, Pritchard-Jones K.

Oncotarget. 2015 Mar 30;6(9):7232-43.


Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours.

Braekeveldt N, Wigerup C, Gisselsson D, Mohlin S, Merselius M, Beckman S, Jonson T, Börjesson A, Backman T, Tadeo I, Berbegall AP, Ora I, Navarro S, Noguera R, Påhlman S, Bexell D.

Int J Cancer. 2015 Mar 1;136(5):E252-61. doi: 10.1002/ijc.29217. Epub 2014 Oct 7.


Reply to Duesberg: Stability of peritriploid and triploid states in neoplastic and nonneoplastic cells.

Valind A, Gisselsson D.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E975. No abstract available.


Reply to Heng: Inborn aneuploidy and chromosomal instability.

Valind A, Gisselsson D.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E973. No abstract available.


Regarding human cytomegalovirus in neuroblastoma.

Forslund O, Holmquist Mengelbier L, Gisselsson D.

Cancer Med. 2014 Aug;3(4):1038-40. doi: 10.1002/cam4.243. Epub 2014 Apr 17.


Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin.

Karlsson J, Holmquist Mengelbier L, Ciornei CD, Naranjo A, O'Sullivan MJ, Gisselsson D.

Genes Chromosomes Cancer. 2014 May;53(5):381-91. doi: 10.1002/gcc.22149. Epub 2014 Feb 1.


Whole chromosome gain does not in itself confer cancer-like chromosomal instability.

Valind A, Jin Y, Baldetorp B, Gisselsson D.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21119-23. doi: 10.1073/pnas.1311163110. Epub 2013 Dec 9.


snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis.

von Stedingk K, Koster J, Piqueras M, Noguera R, Navarro S, Påhlman S, Versteeg R, Ora I, Gisselsson D, Lindgren D, Axelson H.

Transl Oncol. 2013 Aug 1;6(4):447-57. Print 2013 Aug.


Intratumour diversity of chromosome copy numbers in neuroblastoma mediated by on-going chromosome loss from a polyploid state.

Lundberg G, Jin Y, Sehic D, Øra I, Versteeg R, Gisselsson D.

PLoS One. 2013;8(3):e59268. doi: 10.1371/journal.pone.0059268. Epub 2013 Mar 21.


Mutations in CEP57 cause mosaic variegated aneuploidy syndrome.

Snape K, Hanks S, Ruark E, Barros-Núñez P, Elliott A, Murray A, Lane AH, Shannon N, Callier P, Chitayat D, Clayton-Smith J, Fitzpatrick DR, Gisselsson D, Jacquemont S, Asakura-Hay K, Micale MA, Tolmie J, Turnpenny PD, Wright M, Douglas J, Rahman N.

Nat Genet. 2011 Jun;43(6):527-9. doi: 10.1038/ng.822. Epub 2011 May 8.


Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis.

Gisselsson D, Jin Y, Lindgren D, Persson J, Gisselsson L, Hanks S, Sehic D, Mengelbier LH, Øra I, Rahman N, Mertens F, Mitelman F, Mandahl N.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20489-93. doi: 10.1073/pnas.1006829107. Epub 2010 Nov 8.


Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster.

Mengelbier LH, Karlsson J, Lindgren D, Øra I, Isaksson M, Frigyesi I, Frigyesi A, Bras J, Sandstedt B, Gisselsson D.

Am J Pathol. 2010 Nov;177(5):2609-21. doi: 10.2353/ajpath.2010.100130. Epub 2010 Sep 16.


HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells.

Pietras A, Hansford LM, Johnsson AS, Bridges E, Sjölund J, Gisselsson D, Rehn M, Beckman S, Noguera R, Navarro S, Cammenga J, Fredlund E, Kaplan DR, Påhlman S.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16805-10. doi: 10.1073/pnas.0904606106. Epub 2009 Sep 16.


Bone marrow multipotent mesenchymal stroma cells act as pericyte-like migratory vehicles in experimental gliomas.

Bexell D, Gunnarsson S, Tormin A, Darabi A, Gisselsson D, Roybon L, Scheding S, Bengzon J.

Mol Ther. 2009 Jan;17(1):183-90. doi: 10.1038/mt.2008.229. Epub 2008 Nov 4.


Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification.

Lundberg G, Rosengren AH, Håkanson U, Stewénius H, Jin Y, Stewénius Y, Påhlman S, Gisselsson D.

PLoS One. 2008 Aug 29;3(8):e3099. doi: 10.1371/journal.pone.0003099.


Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma.

Rebetz J, Tian D, Persson A, Widegren B, Salford LG, Englund E, Gisselsson D, Fan X.

PLoS One. 2008 Apr 9;3(4):e1936. doi: 10.1371/journal.pone.0001936.


When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses.

Gisselsson D, Håkanson U, Stoller P, Marti D, Jin Y, Rosengren AH, Stewénius Y, Kahl F, Panagopoulos I.

PLoS One. 2008 Apr 2;3(4):e1871. doi: 10.1371/journal.pone.0001871.

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