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Results: 20

1.

Expression of c-myc is not critical for cell proliferation in established human leukemia lines.

Tidd DM, Giles RV, Broughton CM, Clark RE.

BMC Mol Biol. 2001 Nov 16;2:13. Epub 2001 Nov 16.

PMID:
11734062
[PubMed]
Free PMC Article
2.

Determination of optimal sites of antisense oligonucleotide cleavage within TNFalpha mRNA.

Lloyd BH, Giles RV, Spiller DG, Grzybowski J, Tidd DM, Sibson DR.

Nucleic Acids Res. 2001 Sep 1;29(17):3664-73.

PMID:
11522838
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The direction of ribonucleases H by antisense oligodeoxynucleotides.

Giles RV, Tidd DM.

Methods Mol Biol. 2001;160:157-82. Review. No abstract available.

PMID:
11265281
[PubMed - indexed for MEDLINE]
4.

Antisense oligonucleotide technology: from EST to therapeutics.

Giles RV.

Curr Opin Mol Ther. 2000 Jun;2(3):238-52. Review.

PMID:
11249617
[PubMed - indexed for MEDLINE]
5.

Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells.

Moulding DA, Giles RV, Spiller DG, White MR, Tidd DM, Edwards SW.

Blood. 2000 Sep 1;96(5):1756-63.

PMID:
10961874
[PubMed - indexed for MEDLINE]
Free Article
6.

Oligodeoxynucleotide 5mers containing a 5'-CpG induce apoptosis through a mitochondrial mechanism in T lymphocytic leukaemia cells.

Tidd DM, Spiller DG, Broughton CM, Norbury LC, Clark RE, Giles RV.

Nucleic Acids Res. 2000 Jun 1;28(11):2242-50.

PMID:
10871345
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Chimeric oligodeoxynucleotide analogs: chemical synthesis, purification, and molecular and cellular biology protocols.

Giles RV, Spiller DG, Tidd DM.

Methods Enzymol. 2000;313:95-135. No abstract available.

PMID:
10595351
[PubMed - indexed for MEDLINE]
8.

Identification of a good c-myc antisense oligodeoxynucleotide target site and the inactivity at this site of novel NCH triplet--targeting ribozymes.

Giles RV, Spiller DG, Clark RE, Tidd DM.

Nucleosides Nucleotides. 1999 Sep;18(9):1935-44.

PMID:
10549146
[PubMed - indexed for MEDLINE]
9.

Clinical use of streptolysin-O to facilitate antisense oligodeoxyribonucleotide delivery for purging autografts in chronic myeloid leukaemia.

Clark RE, Grzybowski J, Broughton CM, Pender NT, Spiller DG, Brammer CG, Giles RV, Tidd DM.

Bone Marrow Transplant. 1999 Jun;23(12):1303-8.

PMID:
10414920
[PubMed - indexed for MEDLINE]
Free Article
10.

Antisense morpholino oligonucleotide analog induces missplicing of C-myc mRNA.

Giles RV, Spiller DG, Clark RE, Tidd DM.

Antisense Nucleic Acid Drug Dev. 1999 Apr;9(2):213-20.

PMID:
10355827
[PubMed - indexed for MEDLINE]
11.

The influence of target protein half-life on the effectiveness of antisense oligonucleotide analog-mediated biologic responses.

Spiller DG, Giles RV, Broughton CM, Grzybowski J, Ruddell CJ, Tidd DM, Clark RE.

Antisense Nucleic Acid Drug Dev. 1998 Aug;8(4):281-93.

PMID:
9743466
[PubMed - indexed for MEDLINE]
13.

Selecting optimal oligonucleotide composition for maximal antisense effect following streptolysin O-mediated delivery into human leukaemia cells.

Giles RV, Spiller DG, Grzybowski J, Clark RE, Nicklin P, Tidd DM.

Nucleic Acids Res. 1998 Apr 1;26(7):1567-75.

PMID:
9512525
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Preclinical studies of streptolysin-O in enhancing antisense oligonucleotide uptake in harvests from chronic myeloid leukaemia patients.

Broughton CM, Spiller DG, Pender N, Komorovskaya M, Grzybowski J, Giles RV, Tidd DM, Clark RE.

Leukemia. 1997 Sep;11(9):1435-41.

PMID:
9305594
[PubMed - indexed for MEDLINE]
15.

Optimization of antisense oligodeoxynucleotide structure for targeting bcr-abl mRNA.

Giles RV, Spiller DG, Green JA, Clark RE, Tidd DM.

Blood. 1995 Jul 15;86(2):744-54.

PMID:
7606003
[PubMed - indexed for MEDLINE]
Free Article
16.

Single base discrimination for ribonuclease H-dependent antisense effects within intact human leukaemia cells.

Giles RV, Ruddell CJ, Spiller DG, Green JA, Tidd DM.

Nucleic Acids Res. 1995 Mar 25;23(6):954-61.

PMID:
7731809
[PubMed - indexed for MEDLINE]
Free PMC Article
17.
18.

Chimeric oligodeoxynucleotide analogues: enhanced cell uptake of structures which direct ribonuclease H with high specificity.

Giles RV, Spiller DG, Tidd DM.

Anticancer Drug Des. 1993 Feb;8(1):33-51.

PMID:
8386514
[PubMed - indexed for MEDLINE]
19.
20.

Enhanced RNase H activity with methylphosphonodiester/phosphodiester chimeric antisense oligodeoxynucleotides.

Giles RV, Tidd DM.

Anticancer Drug Des. 1992 Feb;7(1):37-48.

PMID:
1311929
[PubMed - indexed for MEDLINE]

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