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In Vitro Activity of Oral Cephalosporins (Cefprozil and Cefixime) Against Ciprofloxacin-Resistant Enterobacteriaceae from Community-Acquired Urinary-Tract Infections.

Pistiki A, Tsaganos T, Galani I, Giamarellos-Bourboulis EJ.

Infect Dis Ther. 2015 Dec;4(4):425-32. doi: 10.1007/s40121-015-0089-3. Epub 2015 Sep 21.


Interactions of Klebsiella pneumoniae with the innate immune system vary in relation to clone and resistance phenotype.

Pantelidou IM, Galani I, Georgitsi M, Daikos GL, Giamarellos-Bourboulis EJ.

Antimicrob Agents Chemother. 2015 Nov;59(11):7036-43. doi: 10.1128/AAC.01405-15. Epub 2015 Sep 8.


NK and NKT Cell Depletion Alters the Outcome of Experimental Pneumococcal Pneumonia: Relationship with Regulation of Interferon-γ Production.

Christaki E, Diza E, Giamarellos-Bourboulis EJ, Papadopoulou N, Pistiki A, Droggiti DI, Georgitsi M, Machova A, Lambrelli D, Malisiovas N, Nikolaidis P, Opal SM.

J Immunol Res. 2015;2015:532717. doi: 10.1155/2015/532717. Epub 2015 May 31.


Compartmentalized Cytokine Responses in Hidradenitis Suppurativa.

Kanni T, Tzanetakou V, Savva A, Kersten B, Pistiki A, van de Veerdonk FL, Netea MG, van der Meer JW, Giamarellos-Bourboulis EJ.

PLoS One. 2015 Jun 19;10(6):e0130522. doi: 10.1371/journal.pone.0130522. eCollection 2015.


Endotoxemia as a diagnostic tool for patients with suspected bacteremia caused by gram-negative organisms: a meta-analysis of 4 decades of studies.

Hurley JC, Nowak P, Öhrmalm L, Gogos C, Armaganidis A, Giamarellos-Bourboulis EJ.

J Clin Microbiol. 2015 Apr;53(4):1183-91. doi: 10.1128/JCM.03531-14. Epub 2015 Jan 28.


The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.

Ten Oever J, Kox M, van de Veerdonk FL, Mothapo KM, Slavcovici A, Jansen TL, Tweehuysen L, Giamarellos-Bourboulis EJ, Schneeberger PM, Wever PC, Stoffels M, Simon A, van der Meer JW, Johnson MD, Kullberg BJ, Pickkers P, Pachot A, Joosten LA, Netea MG.

BMC Immunol. 2014 Nov 19;15:55. doi: 10.1186/s12865-014-0055-y.


Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.

Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, Cheng SC, Ratter J, Berentsen K, van der Ent MA, Sharifi N, Janssen-Megens EM, Ter Huurne M, Mandoli A, van Schaik T, Ng A, Burden F, Downes K, Frontini M, Kumar V, Giamarellos-Bourboulis EJ, Ouwehand WH, van der Meer JW, Joosten LA, Wijmenga C, Martens JH, Xavier RJ, Logie C, Netea MG, Stunnenberg HG.

Science. 2014 Sep 26;345(6204):1251086. doi: 10.1126/science.1251086.


mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG.

Science. 2014 Sep 26;345(6204):1250684. doi: 10.1126/science.1250684. Erratum in: Science. 2014 Nov 7;346(6210):aaa1503. van der Meer, Brian M J W [corrected to van der Veer, Brian M J W].


Obesity as a consequence of gut bacteria and diet interactions.

Kotzampassi K, Giamarellos-Bourboulis EJ, Stavrou G.

ISRN Obes. 2014 Mar 6;2014:651895. doi: 10.1155/2014/651895. eCollection 2014. Review.


Bloodstream infections and sepsis in Greece: over-time change of epidemiology and impact of de-escalation on final outcome.

Koupetori M, Retsas T, Antonakos N, Vlachogiannis G, Perdios I, Nathanail C, Makaritsis K, Papadopoulos A, Sinapidis D, Giamarellos-Bourboulis EJ, Pneumatikos I, Gogos C, Armaganidis A, Paramythiotou E; Hellenic Sepsis Study Group.

BMC Infect Dis. 2014 May 18;14:272. doi: 10.1186/1471-2334-14-272.


Angiopoietin-2 primes infection-induced preterm delivery.

Polyzou EN, Evangelinakis NE, Pistiki A, Kotsaki A, Siristatidis CS, Chrelias CG, Salamalekis E, Kassanos DP, Giamarellos-Bourboulis EJ.

PLoS One. 2014 Jan 21;9(1):e86523. doi: 10.1371/journal.pone.0086523. eCollection 2014.


Dexamethasone Down-Regulates Expression of Triggering Receptor Expressed on Myeloid Cells-1: Evidence for a TNFα-Related Effect.

Mihailidou I, Pelekanou A, Pistiki A, Spyridaki A, Tzepi IM, Damoraki G, Giamarellos-Bourboulis EJ.

Front Public Health. 2013 Nov 14;1:50. doi: 10.3389/fpubh.2013.00050. eCollection 2013.


Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome.

Giamarellos-Bourboulis EJ, Apostolidou E, Lada M, Perdios I, Gatselis NK, Tsangaris I, Georgitsi M, Bristianou M, Kanni T, Sereti K, Kyprianou MA, Kotanidou A, Armaganidis A; Hellenic Sepsis Study Group.

Crit Care. 2013 Oct 21;17(5):R247. doi: 10.1186/cc13073.


The complex pathogenesis of bacteremia: from antimicrobial clearance mechanisms to the genetic background of the host.

Christaki E, Giamarellos-Bourboulis EJ.

Virulence. 2014 Jan 1;5(1):57-65. doi: 10.4161/viru.26514. Epub 2013 Sep 25. Review.


Compartmentalization of lipid peroxidation in sepsis by multidrug-resistant gram-negative bacteria: experimental and clinical evidence.

Toufekoula C, Papadakis V, Tsaganos T, Routsi C, Orfanos SE, Kotanidou A, Carrer DP, Raftogiannis M, Baziaka F, Giamarellos-Bourboulis EJ.

Crit Care. 2013 Jan 16;17(1):R6. doi: 10.1186/cc11930.


Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.

Quintin J, Saeed S, Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, Jacobs L, Jansen T, Kullberg BJ, Wijmenga C, Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, Netea MG.

Cell Host Microbe. 2012 Aug 16;12(2):223-32. doi: 10.1016/j.chom.2012.06.006.


Risk assessment in sepsis: a new prognostication rule by APACHE II score and serum soluble urokinase plasminogen activator receptor.

Giamarellos-Bourboulis EJ, Norrby-Teglund A, Mylona V, Savva A, Tsangaris I, Dimopoulou I, Mouktaroudi M, Raftogiannis M, Georgitsi M, Linnér A, Adamis G, Antonopoulou A, Apostolidou E, Chrisofos M, Katsenos C, Koutelidakis I, Kotzampassi K, Koratzanis G, Koupetori M, Kritselis I, Lymberopoulou K, Mandragos K, Marioli A, Sundén-Cullberg J, Mega A, Prekates A, Routsi C, Gogos C, Treutiger CJ, Armaganidis A, Dimopoulos G.

Crit Care. 2012 Aug 8;16(4):R149. doi: 10.1186/cc11463.


Enhanced interleukin-1β production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals.

Mylona EE, Mouktaroudi M, Crisan TO, Makri S, Pistiki A, Georgitsi M, Savva A, Netea MG, van der Meer JW, Giamarellos-Bourboulis EJ, Joosten LA.

Arthritis Res Ther. 2012 Jul 4;14(4):R158. doi: 10.1186/ar3898.


Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study.

Spyridaki A, Raftogiannis M, Antonopoulou A, Tsaganos T, Routsi C, Baziaka F, Karagianni V, Mouktaroudi M, Koutoukas P, Pelekanou A, Kotanidou A, Orfanos SE, van der Meer JW, Netea MG, Giamarellos-Bourboulis EJ.

Antimicrob Agents Chemother. 2012 Jul;56(7):3819-25. doi: 10.1128/AAC.05798-11. Epub 2012 May 7.


Detrimental effect of apoptosis of lymphocytes at an early time point of experimental abdominal sepsis.

Atmatzidis S, Koutelidakis IM, Chatzimavroudis G, Kotsaki A, Louis K, Pistiki A, Savva A, Antonopoulou A, Atmatzidis K, Giamarellos-Bourboulis EJ.

BMC Infect Dis. 2011 Nov 20;11:321. doi: 10.1186/1471-2334-11-321.

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